[1]武治印),胡劲松)#.A型H1N1流感病毒2009年血凝素蛋白变异分析*[J].郑州大学学报(医学版),2012,(05):610.
 WU Zhiyin),HU Jinsong).Mutation of 2009 type A H1N1 influenza virus hemagglutinin[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(05):610.
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A型H1N1流感病毒2009年血凝素蛋白变异分析*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年05期
页码:
610
栏目:
论著
出版日期:
2012-09-20

文章信息/Info

Title:
Mutation of 2009 type A H1N1 influenza virus hemagglutinin
作者:
武治印1)胡劲松2)#
1)中国医学科学院药用植物研究所 北京 100094 2)国家开发银行 北京 100037
Author(s):
WU Zhiyin1)HU Jinsong2)
1)Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100094 2)China Development Bank,Beijing 100037
关键词:
流感病毒血凝素蛋白变异
Keywords:
influenza virushemagglutininmutation
分类号:
Q349.53
摘要:
目的:通过分析血凝素蛋白的演变规律探讨A型H1N1流感病毒的进化来源及流行特点。方法:利用生物信息学方法,比较A/Mexico/4108/2009(H1N1)毒株和与其相关的22 株流感病毒血凝素蛋白序列的进化关系,重点分析A/Mexico/4108/2009(H1N1)毒株相关氨基酸位点的变异情况。结果:A/Mexico/4108/2009(H1N1)血凝素蛋白的蛋白酶剪切位点、受体结合位点以及表面抗原位点都与1918年和1976年暴发的H1N1流感病毒类似,可能涉及H1N1流感病毒在不同宿主间的传播、重组。结论:A/Mexico/4108/2009(H1N1)毒株的病毒毒力、感染性以及免疫原性发生了一定的变异,并且可能在变异过程中发生了向1918年和1976年的H1N1流感病毒的回复突变。
Abstract:
Aim:To investigate the evolutionary source and the epidemiological characteristics of the type A H1N1 influenza virus by analyzing the evolution of the hemagglutinin protein.Methods:The hemagglutinin amino acid sequences from the A/Mexico/4108/2009(H1N1) strain and its associated other 22 influenza virus strains were collected and compared using bioinformatic methods,and the evolutionary relationship was analyzed.Results:The A/Mexico/4108/2009(H1N1) hemagglutinin protein was the recombination product during its spread among different hosts. And its protease cleavage site, receptor binding sites,and surface antigenic sites were similar to the H1N1 influenza virus epidemic strains outbreak in 1918 and 1976.Conclusion:It demonstrates the variation of the virulence, transmissibility and immunogenicity of A/Mexico/4108/2009(H1N1) strain, and also indicates the response back to the H1N1 virus epidemic strains in 1918 and 1976.

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目3017004,30421004;国家“973”计划基金资助项目2003CB715900 #通讯作者,男,1979年7月生,博士,高级工程师,研究方向:细胞生物学,Email:jingsonghu@126.com
更新日期/Last Update: 1900-01-01