[1]陈杰),李学民),周福有),等.河南食管/贲门癌高发区双胞胎胃体、胃窦黏膜组织病理学比较*[J].郑州大学学报(医学版),2012,(05):619.
 CHEN Jie),LI Xuemin),ZHOU Fuyou),et al.Comparative analysis on histopathological changes at gastric body and antrum of monozygotic and dizygotic twins from esophageal and cardic cancer highincidence area in Henan[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(05):619.
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河南食管/贲门癌高发区双胞胎胃体、胃窦黏膜组织病理学比较*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年05期
页码:
619
栏目:
论著
出版日期:
2012-09-20

文章信息/Info

Title:
Comparative analysis on histopathological changes at gastric body and antrum of monozygotic and dizygotic twins from esophageal and cardic cancer highincidence area in Henan
作者:
陈杰1)李学民2)周福有3)刘静1)黄佳1)尹艳春1)范宗民1)高社干4)李秀敏5)王立东15)#
1)郑州大学第一附属医院河南省食管癌重点开放实验室 郑州 450052 2)磁县医院病理科 磁县 056500 3)安阳肿瘤医院胸外科 安阳 455000 4)河南科技大学第一附属医院肿瘤内科 洛阳 471003 5)新乡医学院癌症研究中心 新乡 453003
Author(s):
CHEN Jie1)LI Xuemin2)ZHOU Fuyou3)LIU Jing1)HUANG Jia1)YIN Yanchun1)FAN Zongmin1)GAO Shegan4)LI Xiumin5)WANG Lidong15)
1)Henan Key Laboratory for Esophageal Cancer,the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Pathology,Cixian Hospital, Cixian 056500 3)Department of Thoracic Surgery,Anyang Tumor Hospital, Anyang 455000 4)Department of Oncology, the First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003 5)Cancer Research Center, Xinxiang Medical University, Xinxiang 453003
关键词:
双胞胎卵型胃体胃窦癌前病变一致率
Keywords:
twins eggtype gastric body gastric antrum precancerous lesionconsistent rate
分类号:
R735.2
摘要:
目的:比较同卵、异卵双胞胎胃体、胃窦黏膜组织病理学变化,为进一步阐明遗传和环境因素对胃癌前病变和癌发生发展的影响提供依据。方法:对190对双胞胎(同卵双胞胎147对,异卵双胞胎43对)进行胃镜检查、胃黏膜活检及组织病理学检查。结果:组织病理学结果发现3对胃癌(1对双发,2对单发);27对不典型增生(胃体部2对均为单发,胃窦部3对双发,22对单发),一致率为11.1%(3/27);31对肠上皮化生(胃体部2对均为单发,胃窦部10对双发,19对单发),一致率为32.3%(10/31)。结论:双胞胎二位成员胃癌前病变和癌检出率低且明显不一致,提示环境因素在胃癌前病变和癌的发生发展中可能起主导作用。
Abstract:
Aim:To compare histopathological changes at gastric body and antrum from monozygotic and dizygotic twins,so as to further illustrate the effects of genetic and environmental factors on the development of gastric precancerous and cancerous lesions.Methods:The gastroscopy, biopsy and histopathological examinations were performed on 190 pairs of twins(147 pairs,monozygotic,43 pairs,dizygotic).Results:The pathological results showed that 3 pairs with gastric cancer (1 double,2 single),27 pairs with dysplasia (2 single at gastric body; 3 double, 22 single at gastric antrum),and the consistent rate was 11.1%(3/27), and 31 pairs with intestinal metaplasia (2 single at gastric body;10 double,19 single at gastric antrum),and the consistent rate was 32.3%(10/31).Conclusion:The prevalence of gastric precancerous and cancerous lesions in the two members of the twins is low and obviously inconsistent,suggesting that environmental factors in the development of gastric precancerous lesions and cancer may play a leading role.

参考文献/References:

[1]Wang LD, Zhou Q, Yang CS. Esophageal and gastric cardia epithelial cell proliferation in northern Chinese subjects living in a high incidence area[J].J Cell Biochem Suppls,1997,128(29):159
[2]王立东, 樊慧, 焦新英, 等. 河南食管癌高发区95对单卵双胞胎疾病谱和2323例食管癌患者家族史调查[J]. 中华肿瘤防治杂志, 2006, 13(20):1521
[3]Wang LD, Liu B, Feng CW, et al. Migration studies on esophageal precancerous and cancerous lesions in Linxian, China[J]. Clin Gastroenterol,2006,40(4):167
[4]逄增昌, 薄涛, 汪韶洁, 等. 青岛市孪生子募集情况分析[J]. 中国公共卫生, 2003,19(1):62
[5]张广平, 王立东, 冯常炜, 等. 食管癌高发区同卵双胞胎食管、贲门和胃窦活检组织病理比较[J].郑州大学学报:医学版,2009,44(1):39
[6]Wang LD, Qiu SL, Yang GR, et al. A randomized double blind intervention study on the effect of calcium supple mentation on esophageal precancerous lesions in a high risk population in China[J]. Cancer Epidemiol Biomarkers Prev, 1993, 2(1): 71
[7]Wang LD, Yue WB, Zhou Y, et al. Endoscopic screening and determination of P53 and proliferating cell nuclear antigen in esophageal multistage carcinogenesis: a comparative study between high and low risk populations in Henan, northern China[J]. Dis Esophagus,2002,15(1):80
[8]Wang LD, Hong JY, Qiu SL, et al. Accumulation of p53 protein in human esophageal precancerous lesions: a possible early biomarker for carcinogenesis [J]. Cancer Res, 1993, 53(8): 1783
[9]王立东, 宋昕. 环境和遗传因素交互作用对食管癌发生的影响[J]. 郑州大学学报:医学版,2011,46(1):1
[10]Heller DA, de Faire U, Pedersen NL, et al. Genetic and environmental influences on serum lipid levels in twins[J].N Engl J Med,1993,328(16):1150
[11]Fraga MF, Ballestar E, Paz MF, et al. Epigenetic differences arise during the lifetime of monozygotic twins[J].Proc Natl Acad Sci USA, 2005, 102(30):10604

相似文献/References:

[1]王立东△.同卵双胞胎与食管癌*[J].郑州大学学报(医学版),2009,(04):698.

备注/Memo

备注/Memo:
*国家科技部“863”重大项目2012AA02A503 #通讯作者,男,1958年8月生,博士,教授,研究方向:食管和贲门癌变机制和防治,Email: ldwang2007@126.com
更新日期/Last Update: 1900-01-01