[1]王素珍△,孟维静,赵晓蒙,等.经倾向指数匹配后的肝癌患者疗效评价*[J].郑州大学学报(医学版),2012,(06):769.
 WANG Suzhen,MENG Weijing,ZHAO Xiaomeng,et al.Effect evaluation of hepatocellular carcinoma patients after propensity score matching[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(06):769.
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经倾向指数匹配后的肝癌患者疗效评价*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年06期
页码:
769
栏目:
论著
出版日期:
2012-11-20

文章信息/Info

Title:
Effect evaluation of hepatocellular carcinoma patients after propensity score matching
作者:
王素珍孟维静赵晓蒙吕军城石福艳
潍坊医学院公共卫生学院卫生统计学教研室 261053
Author(s):
WANG SuzhenMENG WeijingZHAO XiaomengLV JunchengSHI Fuyan
Department of Health Statistics,School of Public Health,Weifang Medical College,Weifang 261053
关键词:
倾向指数匹配法肝癌生存分析
Keywords:
propensity scorematching methodhepatocellular carcinomasurvival analysis
分类号:
R181.2
摘要:
目的:将肝癌患者分为介入治疗(TACE)和介入加放疗(TCR)2组,用倾向指数匹配法均衡组间的协变量,评价2种治疗方式的效果。方法:采用logistic回归模型计算肝癌患者的倾向指数,然后按照倾向指数进行组间卡钳匹配,对匹配后的数据进行生存分析。结果:匹配前2组的生存率差异无统计学意义,LogRank检验的χ2=1792,P=0.181;匹配后差异有统计学意义,LogRank检验的χ2=4.026,P=0.045。结论:采用倾向指数匹配法能有效降低混杂偏倚,对肝癌患者的治疗效果做出正确评价。
Abstract:
Aim:To evaluate the effects of transcatheter arterial chemoembolization(TACE)combined with or without radiation therapy on two groups of hepatocellular carcinoma(HCC) patients after balancing the covariates by propensity score.Methods:Each patient’s propensity score from the model was calculated and made caliper matching according to the propensity score.And then make survival analysis for the matched data.Results:There were no significant differences in the survival rate between the 2 groups before matching,with χ2 of 1.792 and P of 0.181 from LogRank test.But the differences in the survival rate were statistically significant between the 2 groups after matching,with χ2 of 4.026 and P of 0.045 from LogRank test.Conclusion:Propensity score matching method can effectively reduce the confounding bias of nonrandomized clinical observational data,helping us evaluate the curative effect of HCC patients correctly.

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备注/Memo

备注/Memo:
△女,1967年1月生,博士,教授,研究方向:临床试验设计方法及信息处理,Email:wangsz@wfmc.edu.cn
更新日期/Last Update: 2013-07-03