[1]季润元)△,史恩溢),王永实),等.结直肠癌组织中运动相关蛋白1/CD9和ME491/CD63的表达*[J].郑州大学学报(医学版),2012,(06):782.
 JI Runyuan,SHI Enyi,WANG Yongshi,et al.Expressions of MRP1/CD9 and ME491/CD63 in colorectal carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(06):782.
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结直肠癌组织中运动相关蛋白1/CD9和ME491/CD63的表达*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年06期
页码:
782
栏目:
论著
出版日期:
2012-11-20

文章信息/Info

Title:
Expressions of MRP1/CD9 and ME491/CD63 in colorectal carcinoma tissue
作者:
季润元1)史恩溢2)王永实1)李小宁2)赵玉芳3)冯振卿4)
1)淮阴卫生高等职业技术学校;淮安市消化道肿瘤重点实验室 淮安 223300
2)苏州卫生职业技术学院病理教研室 苏州 215009
3)淮安市肿瘤医院病理科 淮安 223200
4)南京医科大学病理学系 南京 210029
Author(s):
JI Runyuan1)SHI Enyi2)WANG Yongshi1)LI Xiaoning2)ZHAO Yufang3)FENG Zhenqing4)
1)Huaiyin Advanced Vocational and Technical Hygiene School;Huai’an Key Lab of the Tumor of Digestive System,Huai’an 223300
2)Department of Pathology,Suzhou Health College,Suzhou 215009
3)Department of Pathology,Cancer Hospital of Huai’an City,Huai’an 223200
4)Department of Pathology,Nanjing Medical University,Nanjing 210029
关键词:
结直肠癌运动相关蛋白1/CD9ME491/CD63
Keywords:
colorectal carcinomamobility related protein1/CD9ME491/CD63
分类号:
R735.3
摘要:
目的:研究结直肠癌组织中运动相关蛋白1(MRP1)/CD9和ME491/CD63的表达及其临床意义。方法:应用组织芯片的免疫组织化学技术检测239例结直肠癌组织中MRP1/CD9和ME491/CD63的表达。结果:MRP1/CD9在结直肠癌组织中的表达与肿瘤的分化程度、Dukes分期、淋巴结转移有关(χ2=8.930、7.430和5.857,P均<0.05),而与患者的性别、年龄、浸润深度无关(χ2=1.800,0.014和0.096,P均>0.05)。ME491/CD63的表达与结直肠癌临床病理指标无关。结直肠癌组织中MRP1/CD9和ME491/CD63的表达呈正关联(rP=0.311,P<0.001)。结论:MRP1/CD9可作为结直肠癌的预后因子。结直肠癌组织中MRP1/CD9和ME491/CD63的表达呈正关联。
Abstract:
Aim:To study the expressions of mobility related protein1(MRP1)/CD9 and ME491/CD63 in colorectal carcinoma tissue.Methods:Tissue microarray and immunohistochemistry were used to detect the expressions of MRP1/CD9 and ME491/CD63 in 239 cases of colorectal carcinoma.The correlations between MRP1/CD9 and ME491/CD63 expression as well as the clinical and pathological characteristics were analyzed.Results:The expression of MRP1/CD9 was closely related with the differentiated degree,Dukes stages,and lymph node metastasis(χ2=8.930,7.430,5.857;P<0.05).And it had no relationship with the patients’ sex,age,or the depth of infiltration(χ2=1.800,0.014,0.096,P>0.05).No correlation was found between the expression of ME491/CD63 in colorectal carcinoma and its clinicopathological materials.Positive association was found between the expression of MRP1/CD9 and ME491/CD63(rP=0.311,P<0.001).Conclusion:The expression of MRP1/CD9 is a prognostic factor of colorectal carcinoma.The expression of MRP1/CD9 significantly correlates with the expression of ME491/CD63.

参考文献/References:

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备注/Memo

备注/Memo:
*江苏省卫生厅医学科技发展基金资助项目J201116;△男,1969年1月生,硕士,副教授,研究方向:肿瘤病理,Email:christ7777@163.com
更新日期/Last Update: 2013-07-03