[1]赵瑛瑛)△,欧阳军),王建生),等.血清胱抑素C检测在造影剂肾病早期诊断中的价值[J].郑州大学学报(医学版),2012,(06):830.
 ZHAO Yingying,OU Yangjun,WANG Jiansheng,et al.Value of serum cystatin C in early diagnosis of contrast induced nephropathy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(06):830.
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血清胱抑素C检测在造影剂肾病早期诊断中的价值
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年06期
页码:
830
栏目:
应用研究
出版日期:
2012-11-20

文章信息/Info

Title:
Value of serum cystatin C in early diagnosis of contrast induced nephropathy
作者:
赵瑛瑛1)欧阳军2)王建生1)张宛哲1)张文吉1)孟晶茜1)申鹏霄1)刘丁1)汤建民3)
1)郑州大学第二附属医院肾内科 郑州 450014
2)河南省医药科学研究院 郑州 450052
3)郑州大学第二附属医院心血管内科 郑州 450014
Author(s):
ZHAO Yingying1)OU Yangjun2)WANG Jiansheng2)ZHANG Wanzhe1)ZHANG Wenji1)MENG Jingqian1)SHEN Pengxiao1)LIU Ding1)TANG Jianmin3)
1)Department of Nephrology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014;
2)Medical Science Research Institute of Henan Province,Zhengzhou 450052
3)Department of Cardiology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014
关键词:
胱抑素C冠状动脉造影术造影剂肾病
Keywords:
cystatin Ccoronary angiographycontrast induced nephropathy
分类号:
R692
摘要:
目的:探讨血清胱抑素C(CysC)检测在造影剂肾病(CIN)早期诊断中的意义。方法:采用回顾性研究的方法,选择接受冠状动脉造影术和(或)经皮冠状动脉介入治疗术的冠心病患者为研究对象,收集患者造影前、造影后24 h和48 h血清CysC、血清肌酐等相关临床资料,比较血清CysC与Scr检测在造影剂肾病早期诊断的特异性和敏感度。结果:与造影前[(1.03±0.18)mg/L]比较,427例研究对象造影后24 h[(1.27±0.21)mg/L]和48 h[(1.31±0.26)mg/L]血清CysC升高,差异有统计学意义(F=39.542,P=0.031)。以血清肌酐变化为诊断指标,造影后24 h和48 h CIN的发生率分别为6.57% 和7.20%,均低于以血清CysC法诊断标准下CIN的发生率(1017%和10.81%,χ2=262.359和236.669,P均<0.001)。运用血清CysC法在造影后24 h诊断CIN的灵敏度和特异度分别为96.77%和95.92%,造影后48 h为91.18%和95.43%。结论:CysC可敏感地反映造影剂肾毒性程度,有利于造影剂肾病的早期诊断。
Abstract:
Aim:To study the value of detecting serum cystatin C(CysC) in early diagnosis of contrast induced nephropathy(CIN).Methods:Taking retrospective analysis method,a total of 427 patients undergoing diagnostic coronary angiography or percutaneous coronary intervention were enrolled.Serum CysC,serum creatinine(Scr) and other relevant clinical data of the patients were collected before imaging and 24 hours,48 hours after imaging.Two methods were used to diagnose CIN.A:detecting the level of Scr;B:detecting the level of serum CysC.The specificity and sensitivity of the above two methods were analyzed respectively.Results:Compared with that before imaging[(103±0.18)mg/L],the serum CysC increased significantly at 24 hours[(1.27±0.21)mg/L] and 48 hours[(1.31±0.26)mg/L] after imaging(F=39.542,P=0.031).By method A,the incidence of CIN were 6.57% at 24 hours after imaging and 7.20% at 48 hours after imaging,which were lower than those by method B(10.17% and 10.81%,χ2=262.359 and 236.669,P<0.001).By method B,the specificity and sensitivity of diagnosing CIN were 96.77% and 9592% at 24 hours after imaging,91.18% and 9543% at 48 hours after imaging.Conclusion:The level of serum CysC could be a sensitive marker to diagnose CIN in early stage.

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备注/Memo

备注/Memo:
△女,1973年1月生,硕士,副主任医师,研究方向:肾小球病,Email:zhaoyingying9601@sina.com
更新日期/Last Update: 2013-07-03