[1]张竞超△,牛冬林,赵文增,等.NFκB阻滞剂PDTC在冠脉搭桥术中对心肌的保护效果[J].郑州大学学报(医学版),2012,(06):836.
 ZHANG Jingchao,NIU Donglin,ZHAO Wenzeng,et al.Effects of NFκB retardant PDTC on myocardium during coronary artery bypass grafting[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(06):836.
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NFκB阻滞剂PDTC在冠脉搭桥术中对心肌的保护效果
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年06期
页码:
836
栏目:
应用研究
出版日期:
2012-11-20

文章信息/Info

Title:
Effects of NFκB retardant PDTC on myocardium during coronary artery bypass grafting
作者:
张竞超牛冬林赵文增苗岩
郑州大学第一附属医院心血管外科 郑州 450052
Author(s):
ZHANG JingchaoNIU DonglinZHAO WenzengMIAO Yan
Department of Cardiovascular Surgery,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
心肌保护NFκB吡咯烷二硫代氨基甲酸钠心肌酶
Keywords:
myocardium protectionNFκBaminodithioformic acidmyocardial enzyme
分类号:
R654.1
摘要:
目的:探讨心脏手术过程中NFκB阻滞剂对心肌的影响。方法:将20例同期拟行冠脉搭桥术(CABG)患者分为对照组和观察组各10例,2组麻醉方式相同,均采用体外循环下停跳搭桥术,术中分别用含NFκB阻滞剂PDTC(观察组)和普通的冷晶体停搏液(对照组)作为心肌保护液。2组分别于术前1 h、术中、术后1 h、术后24 h测定患者血清肌酸激酶同工酶(CKMB)、心肌肌钙蛋白I(cTnI)、乳酸脱氢酶(LDH)水平。结果:2组术前1 h血清CKMB、cTnI和LDH水平差异无统计学意义,而术中、术后2组血清CKMB、cTnI、LDH均升高,但观察组3个指标的水平均低于对照组(F组间分别为121.003、32.326和250.088,F时间分别为53.802、51.574和227.901,P均<005)。结论:NFκB阻滞剂可有效减轻CABG患者的心肌损伤。
Abstract:
Aim:To observe the protective effect of the NFκB retardant on myocardium during coronary artery bypass grafting(CABG).Methods:A total of 20 patients undergoing CABG were allocated into two groups.Group A was given cold crystal cardioplegia containing the NFκB retardant PDTC,and group B used the ordinary cold crystal cardioplegia.The 2 groups were given the same narcosis and operation way.Before the operation,during the operation,1 h and 24 h after the operation,the serum levels of creatine kinase(CKMB),myocardium troponin(cTnI) and lactic dehydrogenase(LDH) were determined.Results:There were no statistic differences in the indexes mentioned above between the 2 groups before the operation(P>0.05).The levels of CKMB,cTnI and LDH of the 2 groups were higher during the operation,1 h and 24 h after the operation than before the operation,but those of group A were lower than group B(Fgroup=121.003,32.326 and 250088;Ftime=53.802,51.574 and 227.901;P<0.05).Conclusion:The NFκB retardant could reduce the injury to myocardium during CABG.

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备注/Memo

备注/Memo:
△男,1968年3月生,博士,副主任医师,副教授,研究方向:心肌保护的机制,Email:niudonglin@126.com
更新日期/Last Update: 2013-07-03