[1]岳冬丽),韩交玲),关方霞),等.肿瘤干细胞的研究进展及临床意义[J].郑州大学学报(医学版),2013,(01):1.
点击复制

肿瘤干细胞的研究进展及临床意义
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年01期
页码:
1
栏目:
特约述评
出版日期:
2013-01-20

文章信息/Info

作者:
岳冬丽12)韩交玲13)关方霞3)张毅13)#
1)郑州大学第一附属医院生物细胞治疗中心 郑州 450052 2)郑州大学第一附属医院肿瘤科 郑州 450052 3)郑州大学生物工程系 郑州 450001
关键词:
肿瘤干细胞干细胞表面标志物肿瘤干细胞疫苗

参考文献/References:

[1]Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69
[2]Sell S.Stem cell origin of cancer and differentiation therapy[J].Crit Rev Oncol Hematol,2004,51(1):1
[3]Reya T,Morrison SJ,Clarke MF,et al.Stem cells,cancer,and cancer stem cells[J].Nature,2001,414(6859):105
[4]Hamburger AW,Salmon SE.Primary bioassay of human tumor stem cells[J].Science,1977,197(4302):461
[5]Bonnet D,Dick JE.Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell[J].Nat Med,1997,3(7):730
[6]AlHajj M,Wicha MS,BenitoHernandez A,et al.Prospective identification of tumorigenic breast cancer cells[J].Proc Natl Acad Sci USA,2003,100(7):3983
[7]VelascoVelazquez MA,Homsi N,De La Fuente M,et al.Breast cancer stem cells[J].Int J Biochem Cell Biol,2012,44(4):573
[8]Meirelles K,Benedict LA,Dombkowski D,et al.Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance[J].Proc Natl Acad Sci USA,2012,109(7):2358
[9]Kryczek I,Liu S,Roh M,et al.Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells[J].Int J Cancer,2012,130(1):29
[10]Salmanzadeh A,Romero L,Shafiee H,et al.Isolation of prostate tumor initiating cells(TICs) through their dielectrophoretic signature[J].Lab Chip,2012,12(1):182
[11]O’Brien CA,Pollett A,Gallinger S,et al.A human colon cancer cell capable of initiating tumour growth in immunodeficient mice[J].Nature,2007,445(7123):106
[12]Singh SK,Clarke ID,Terasaki M,et al.Identification of a cancer stem cell in human brain tumors[J].Cancer Res,2003,63(18):5821
[13]Clarke MF,Dick JE,Dirks PB,et al.Cancer stem cellsperspectives on current status and future directions:AACR Workshop on cancer stem cells[J].Cancer Res,2006,66(19):9339
[14]Cao L,Zhou Y,Zhai B,et al.Sphereforming cell subpopulations with cancer stem cell properties in human hepatoma cell lines[J].BMC Gastroenterol,2011,11:71
[15]Zhang Y,Wang Z,Yu J,et al.Cancer stemlike cells contribute to cisplatin resistance and progression in bladder cancer[J].Cancer Lett,2012,322(1):70
[16]Zhang L,Jiao M,Li L,et al.Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties[J].J Cancer Res Clin Oncol,2012,138(4):675
[17]Lopez J,Poitevin A,MendozaMartinez V,et al.Cancerinitiating cells derived from established cervical cell lines exhibit stemcell markers and increased radioresistance[J].BMC Cancer,2012,12:48
[18]Piao LS,Hur W,Kim TK,et al.CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma[J].Cancer Lett,2012,315(2):129
[19]Reya T,Clevers H.Wnt signalling in stem cells and cancer[J].Nature,2005,434(7035):843
[20]Vermeulen L,De Sousa E Melo F,van der Heijden M,et al.Wnt activity defines colon cancer stem cells and is regulated by the microenvironment[J].Nat Cell Biol,2010,12(5):468
[21]Yu S,Zhang R,Liu F,et al.Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stemlike side population cells[J].Oncol Rep,2012,28(2):561
[22]Santini R,Vinci MC,Pandolfi S,et al.HedgehogGLI signaling drives selfrenewal and tumorigenicity of human melanomainitiating cells[J].Stem Cells,2012,30(9):1808
[23]Massague J,Xi Q.TGFbeta control of stem cell differentiation genes[J].FEBS Lett,2012,586(14):1953
[24]Wang H,Wu J,Zhang Y,et al.Transforming growth factor betainduced epithelialmesenchymal transition increases cancer stemlike cells in the PANC1 cell line[J].Oncol Lett,2012,3(1):229
[25]Ye J,Wu D,Shen J,et al.Enrichment of colorectal cancer stem cells through epithelialmesenchymal transition via CDH1 knockdown[J].Mol Med Report,2012,6(3):507
[26]Yoon CH,Kim MJ,Lee H,et al.PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population[J].J Biol Chem,2012,287(23):19516
[27]Wang YC,Yo YT,Lee HY,et al.ALDH1bright epithelial ovarian cancer cells are associated with CD44 expression,drug resistance,and poor clinical outcome[J].Am J Pathol,2012,180(3):1159
[28]Chen SF,Chang YC,Nieh S,et al.Nonadhesive culture system as a model of rapid sphere formation with cancer stem cell properties[J].PLoS One,2012,7(2):e31864
[29]Bhaskara VK,Mohanam I,Rao JS,et al.Intermittent hypoxia regulates stemlike characteristics and differentiation of neuroblastoma cells[J].PLoS One,2012,7(2):e30905
[30]Hu X,Ghisolfi L,Keates AC,et al.Induction of cancer cell stemness by chemotherapy[J].Cell Cycle,2012,11(14):2691
[31]Chien CY,Chuang HC,Chen CH.The side population of cancer stemlike cells in human oral cancer[J].Oral Oncol,2012,48(10):913
[32]Zhang S,Balch C,Chan MW,et al.Identification and characterization of ovarian cancerinitiating cells from primary human tumors[J].Cancer Res,2008,68(11):4311
[33]Meng E,Long B,Sullivan P,et al.CD44+/CD24- ovarian cancer cells demonstrate cancer stem cell properties and correlate to survival[J].Clin Exp Metastasis,2012,29(8):939
[34]Ginestier C,Hur MH,CharafeJauffret E,et al.ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome[J].Cell Stem Cell,2007,1(5):555
[35]Dubrovska A,Kim S,Salamone RJ,et al.The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stemlike cell populations[J].Proc Natl Acad Sci U S A,2009,106(1):268
[36]Collins AT,Berry PA,Hyde C,et al.Prospective identification of tumorigenic prostate cancer stem cells[J].Cancer Res,2005,65(23):10946
[37]Hurt EM,Kawasaki BT,Klarmann GJ,et al.CD44+CD24(-) prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis[J].Br J Cancer,2008,98(4):756
[38]Patrawala L,Calhoun T,SchneiderBroussard R,et al.Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells[J].Oncogene,2006,25(12):1696
[39]Hellsten R,Johansson M,Dahlman A,et al.Galiellalactone inhibits stem celllike ALDHpositive prostate cancer cells[J].PLoS One,2011,6(7):e22118
[40]Rutella S,Bonanno G,Procoli A,et al.Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors[J].Clin Cancer Res,2009,15(13):4299
[41]Yao T,Chen Q,Zhang B,et al.The expression of ALDH1 in cervical carcinoma[J].Med Sci Monit,2011,17(8):HY21
[42]Su J,Xu XH,Huang Q,et al.Identification of cancer stemlike CD44+ cells in human nasopharyngeal carcinoma cell line[J].Arch Med Res,2011,42(1):15
[43]Zhao JS,Li WJ,Ge D,et al.Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44[J].PLoS One,2011,6(6):e21419
[44]Huang SD,Yuan Y,Liu XH,et al.Selfrenewal and chemotherapy resistance of p75NTR positive cells in esophageal squamous cell carcinomas[J].BMC Cancer,2009,9:9
[45]Takaishi S,Okumura T,Tu S,et al.Identification of gastric cancer stem cells using the cell surface marker CD44[J].Stem Cells,2009,27(5):1006
[46]Song W,Li H,Tao K,et al.Expression and clinical significance of the stem cell marker CD133 in hepatocellular carcinoma[J].Int J Clin Pract,2008,62(8):1212
[47]Ma S,Chan KW,Hu L,et al.Identification and characterization of tumorigenic liver cancer stem/progenitor cells[J].Gastroenterology,2007,132(7):2542
[48]Yang ZF,Ngai P,Ho DW,et al.Identification of local and circulating cancer stem cells in human liver cancer[J].Hepatology,2008,47(3):919
[49]Dalerba P,Dylla SJ,Park IK,et al.Phenotypic characterization of human colorectal cancer stem cells[J].Proc Natl Acad Sci USA,2007,104(24):10158
[50]RicciVitiani L,Lombardi DG,Pilozzi E,et al.Identification and expansion of human coloncancerinitiating cells[J].Nature,2007,445(7123):111
[51]Du L,Wang H,He L,et al.CD44 is of functional importance for colorectal cancer stem cells[J].Clin Cancer Res,2008,14(21):6751
[52]Carpentino JE,Hynes MJ,Appelman HD,et al.Aldehyde dehydrogenaseexpressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer[J].Cancer Res,2009,69(20):8208
[53]Hermann PC,Huber SL,Herrler T,et al.Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer[J].Cell Stem Cell,2007,1(3):313
[54]Li C,Heidt DG,Dalerba P,et al.Identification of pancreatic cancer stem cells[J].Cancer Res,2007,67(3):1030
[55]Bussolati B,Bruno S,Grange C,et al.Identification of a tumorinitiating stem cell population in human renal carcinomas[J].FASEB J,2008,22(10):3696
[56]Jones RJ,Gocke CD,Kasamon YL,et al.Circulating clonotypic B cells in classic Hodgkin lymphoma[J].Blood,2009,113(23):5920
[57]Cheung AM,Wan TS,Leung JC,et al.Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential[J].Leukemia,2007,21(7):1423
[58]Jin L,Hope KJ,Zhai Q,et al.Targeting of CD44 eradicates human acute myeloid leukemic stem cells[J].Nat Med,2006,12(10):1167
[59]Yamazaki H,Nishida H,Iwata S,et al.CD90 and CD110 correlate with cancer stem cell potentials in human Tacute lymphoblastic leukemia cells[J].Biochem Biophys Res Commun,2009,383(2):172
[60]Mitra M,Kandalam M,Harilal A,et al.EpCAM is a putative stem marker in retinoblastoma and an effective target for Tcellmediated immunotherapy[J].Mol Vis,2012,18:290
[61]Eramo A,Lotti F,Sette G,et al.Identification and expansion of the tumorigenic lung cancer stem cell population[J].Cell Death Differ,2008,15(3):504
[62]Dou J,Pan M,Wen P,et al.Isolation and identification of cancer stemlike cells from murine melanoma cell lines[J].Cell Mol Immunol,2007,4(6):467
[63]Monzani E,Facchetti F,Galmozzi E,et al.Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential[J].Eur J Cancer,2007,43(5):935
[64]Civenni G,Walter A,Kobert N,et al.Human CD271positive melanoma stem cells associated with metastasis establish tumor heterogeneity and longterm growth[J].Cancer Res,2011,71(8):3098
[65]Tirino V,Desiderio V,d’Aquino R,et al.Detection and characterization of CD133+ cancer stem cells in human solid tumours[J].PLoS One,2008,3(10):e3469
[66]Wang L,Park P,Zhang H,et al.Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS991 cells based on high aldehyde dehydrogenase activity[J].Int J Cancer,2011,128(2):294
[67]Suva ML,Riggi N,Stehle JC,et al.Identification of cancer stem cells in Ewing’s sarcoma[J].Cancer Res,2009,69(5):1776
[68]Yunoue S,Arita K,Kawano H,et al.Identification of CD133+ cells in pituitary adenomas[J].Neuroendocrinology,2011,94(4):302
[69]Prince ME,Sivanandan R,Kaczorowski A,et al.Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma[J].Proc Natl Acad Sci U S A,2007,104(3):973
[70]Clay MR,Tabor M,Owen JH,et al.Singlemarker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase[J].Head Neck,2010,32(9):1195
[71]Steffensen KD,Alvero AB,Yang Y,et al.Prevalence of epithelial ovarian cancer stem cells correlates with recurrence in earlystage ovarian cancer[J].J Oncol,2011,2011:620523
[72]Silva IA,Bai S,McLean K,et al.Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival[J].Cancer Res,2011,71(11):3991
[73]Marcato P,Dean CA,Pan D,et al.Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis[J].Stem Cells,2011,29(1):32
[74]Curley MD,Garrett LA,Schorge JO,et al.Evidence for cancer stem cells contributing to the pathogenesis of ovarian cancer[J].Front Biosci,2011,16:368
[75]Vaiopoulos AG,Kostakis ID,Koutsilieris M,et al.Colorectal cancer stem cells[J].Stem Cells,2012,30(3):363
[76]Bao S,Wu Q,McLendon RE,et al.Glioma stem cells promote radioresistance by preferential activation of the DNA damage response[J].Nature,2006,444(7120):756
[77]Frank NY,Margaryan A,Huang Y,et al.ABCB5mediated doxorubicin transport and chemoresistance in human malignant melanoma[J].Cancer Res,2005,65(10):4320
[78]Jang JY,Kim MK,Jeon YK,et al.Adenovirus adenine nucleotide translocator2 shRNA effectively induces apoptosis and enhances chemosensitivity by the downregulation of ABCG2 in breast cancer stemlike cells[J].Exp Mol Med,2012,44(4):251
[79]Cheng C,Liu ZG,Zhang H,et al.Enhancing chemosensitivity in ABCB1 and ABCG2overexpressing cells and cancer stemlike cells by an aurora kinase inhibitor CCT129202[J].Mol Pharm,2012,Jun 13[Epub ahead of print]
[80]Eyler CE,Rich JN.Survival of the fittest:cancer stem cells in therapeutic resistance and angiogenesis[J].J Clin Oncol,2008,26(17):2839
[81]Ding XW,Wu JH,Jiang CP.ABCG2:a potential marker of stem cells and novel target in stem cell and cancer therapy[J].Life Sci,2010,86(17/18):631
[82]Singh S,Srivastava SK,Bhardwaj A,et al.CXCL12CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells:a novel target for therapy[J].Br J Cancer,2010,103(11):1671
[83]Visus C,Wang Y,LozanoLeon A,et al.Targeting ALDH(bright) human carcinomainitiating cells with ALDH1A1specific CD8(+) T cells[J].Clin Cancer Res,2011,17(19):6174
[84]Ning N,Pan Q,Zheng F,et al.Cancer stem cell vaccination confers significant antitumor immunity[J].Cancer Res,2012,72(7):1853
[85]Shmelkov SV,Butler JM,Hooper AT,et al.CD133 expression is not restricted to stem cells,and both CD133+ and CD133- metastatic colon cancer cells initiate tumors[J].J Clin Invest,2008,118(6):2111

相似文献/References:

[1]郑乃刚)),阎爱华),吴景兰),等.食管鳞癌的肿瘤干细胞标志[J].郑州大学学报(医学版),2010,(01):27.
 ZHENG Naigang),YAN Aihua),WU Jinglan),et al.Cancer stem cell biomarker in human esophageal squamous cell carcinoma tissue and Eca109 and EC9706 cells[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(01):27.
[2]葛丽丽,杨小昂#.肝癌细胞系Huh7中EpCAM+细胞亚群的肿瘤干细胞样特性*[J].郑州大学学报(医学版),2012,(03):306.
 GE Lili,YANG Xiaoang.Cancer stem celllike properties of EpCAM+ cell subpopulation in hepatocellular carcinoma cell line Huh7[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(01):306.
[3]谢爱民△,胡建明,陈艰,等.肺癌组织中SOX2和βcatenin蛋白的表达[J].郑州大学学报(医学版),2014,(01):105.
 XIE Aimin,HU Jianming,CHEN Jian,et al.Expressions of SOX2 and βcatenin protein in lung cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(01):105.

备注/Memo

备注/Memo:
#通讯作者,张毅,男,1964年4月生,博士,教授,研究方向:肿瘤免疫学、肿瘤干细胞和生物细胞治疗,Email:chyizhang@gmail.com;关方霞,女,1969年6月生,博士,教授,研究方向:干细胞生物学,Email:guanfx@zzu.edu.cn
更新日期/Last Update: 2013-04-19