[1]李洪雷),范宗民),王伟鹏),等.AHDC1基因变异及临床病理指标对食管癌高低发区患者生存期的影响*[J].郑州大学学报(医学版),2013,(01):12.
 LI Honglei,FAN Zongmin,WANG Weipeng,et al.Effects of AHDC1 genetic variation and clinicopathological factors on survival of patients with esophageal cancer from high and lowincidence areas[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(01):12.
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AHDC1基因变异及临床病理指标对食管癌高低发区患者生存期的影响*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年01期
页码:
12
栏目:
食管癌研究
出版日期:
2013-01-20

文章信息/Info

Title:
Effects of AHDC1 genetic variation and clinicopathological factors on survival of patients with esophageal cancer from high and lowincidence areas
作者:
李洪雷1)范宗民1)王伟鹏12)周胜理1)王亚豪3)黄静1)董金成4)李贝1)郭金生5)张连群16)王立东1)#
1)郑州大学第一附属医院河南省食管癌重点开放实验室;郑州大学基础医学院 郑州 450052 2)磁县医院胃镜室 磁县 056500 3)河南科技大学第一附属医院呼吸内科 洛阳 471003 4)淇县卫生局 淇县 456750 5)姚村食管癌医院普外科 林州 456592 6)安阳肿瘤医院胃镜室 安阳 455000
Author(s):
LI Honglei1)FAN Zongmin1)WANG Weipeng12)ZHOU Shengli1)WANG Yahao3)HUANG Jing1)DONG Jincheng4)LI Bei1)GUO Jinsheng5)ZHANG Lianqun16)WANG Lidong1)
1)Henan Key Laboratory for Esophageal Cancer Research,the First Affiliated Hospital,Zhengzhou University;College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450052 2)Department of Endoscope,Cixian Hospital,Cixian 056500 3)Department of Respiratory Diseases,the First Affiliated Hospital,Henan University of Science and Technology,Luoyang 471003 4)Qixian Health Bureau,Qixian 456750 5)Department of General Surgery,Yaocun Esophageal Cancer Hospital,Linzhou 456592 6)Department of Endoscope,Anyang Cancer Hospital,Anyang 455000
关键词:
食管癌生存期AHDC1淋巴结转移临床分期
Keywords:
esophageal carcinomasurvivalAHDC1lymph node metastasisclinical stage
分类号:
R735.1
摘要:
目的:探讨AHDC1基因变异及临床病理指标对食管癌高低发区患者生存期的影响,加深对食管癌预后分子机制的认识。方法:采用入户家访、现场问卷普查、电话随访和住院病理核查等方法收集3 478例食管癌患者的临床病理资料和死亡情况;采集每例患者空腹外周静脉血5 mL,采用Taqman基因分型技术检测AHDC1基因rs4908343位点的变异情况。结果:KaplanMeier分析显示AHDC1基因AA/AG型患者5 a生存率高于GG型患者,浸润黏膜层患者高于浸润肌层和浆膜层患者,无淋巴结转移患者高于有淋巴结转移患者,早期患者高于中晚期患者,手术治疗的患者高于非手术患者,食管癌高发区患者高于低发区患者(χ2=6.650、52.756、39087、61314、75635、175.205,P均<0.05);Cox回归模型分析提示AHDC1基因GG型[RR(95%CI)=1.197(1.008~1421)]、中晚期[RR(95%CI)=2.004(1.358~2.956)和3.594(2.392~5.399)]及低发区[RR(95%CI)=2.891(2243~3.726)]影响食管癌患者的预后(P均<0.05)。结论:AHDC1基因型、临床分期及高低发区是影响食管癌预后的重要因素。
Abstract:
Aim:To study the influence of AHDC1 genetic variation and changes in clinicopathology on survival of esophageal cancer(EC)patients from the high and lowincidence areas,and to highlight the molecular mechanism of EC prognosis.Methods:Home interview,questionnaire,telephone followup and hospital pathology verification were applied to get the clinical pathology and survival data of 3 478 cases of EC.Fasting peripheral blood samples were collected for each patient.The Taqman method was used to detect the variation of rs4908343 locus on AHDC1 gene.Results:Fiveyear survival rate of the patients with AA/AG genotypes of AHDC1 was higher than those with GG genotype(χ2=6.650,P=0010).The patients with superficial infiltration,without lymph node metastasis,at early stage,accepted surgery,or living in highincidence area of EC had higher 5year survival rate(χ2=52.756,39087,61.314,75.635,175.205,P<0.05).Cox multivariable analysis showed that GG genotype of AHDC1,advanced stage,and lowincidence area were the independent prognostic factors for EC patients(P<0.05).Conclusion:Cenotype of AHDC1 gene,clinical stage and high and lowincidence area are important factors affecting the prognosis of EC patients.

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备注/Memo

备注/Memo:
*国家科技部863重大项目2012AA02A503 #通讯作者,男,1958年8月生,博士,教授,研究方向:食管/贲门癌变机制和防治,Email:ldwang2007@126.com
更新日期/Last Update: 2013-04-19