[1]牛原源),李新华)﹟,赵晓燕),等.血浆脂蛋白相关磷脂酶A2水平对冠状动脉粥样硬化的评价价值[J].郑州大学学报(医学版),2013,(01):103.
 NIU Yuanyuan,LI Xinhua,ZHAO Xiaoyan,et al.Values of plasma lipoproteinassociated phospholipase A2 level for coronary artery atherosclerosis assessment[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(01):103.
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血浆脂蛋白相关磷脂酶A2水平对冠状动脉粥样硬化的评价价值
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年01期
页码:
103
栏目:
应用研究
出版日期:
2013-01-20

文章信息/Info

Title:
Values of plasma lipoproteinassociated phospholipase A2 level for coronary artery atherosclerosis assessment
作者:
牛原源1)李新华1)赵晓燕2)武丽娜1)吴世陶1)吴斐1)李文龙3)
1)郑州大学第五附属医院心血管内科 郑州 450052 2)郑州大学第一附属医院心血管内科 郑州 450052 3)濮阳市安阳地区医院心内科 安阳 455000
Author(s):
NIU Yuanyuan1)LI Xinhua1)ZHAO Xiaoyan2)WU Lina1)WU Shitao1)WU Fei1)LI Wenlong3)
1)Department of Cardiology,the Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 3)Department of Cardiology,Anyang Area Hospital of Puyang,Puyang 455000
关键词:
脂蛋白相关磷脂酶A2血管内超声虚拟组织学成像冠状动脉粥样硬化
Keywords:
lipoproteinassociated phospholipase A2IVUSVHcoronary arteryatherosclerosis
分类号:
R542.2
摘要:
目的:评价血浆脂蛋白相关磷脂酶A2(LPPLA2)水平对冠状动脉粥样硬化严重程度及不良事件风险的预测价值。方法:对45例急性冠脉综合征(ACS)患者和35例稳定性心绞痛(SA)患者行冠脉造影(QCA)检查和IVUSVH分析,同时行血浆LPPLA2水平测定。结果:ACS组斑块坏死核心、钙化成分比例较SA组高(t=5.655,10.974,P<0.001)。ACS组患者冠状动脉病变处以正性重构为主,SA组以负性重构为主(χ2=40.555,P<0.001)。ACS组患者血浆LPPLA2水平较SA组显著升高(t=2.934,P=0.004)。ACS和SA组患者随着Gensini积分增加,血浆LPPLA2水平均逐渐增高(F=4.227,3.783,P<0.05)。ACS患者斑块中坏死核心比例与血浆LPPLA2水平呈明显正相关(r=0.439,P=0.003)。结论:血浆LPPLA2水平可用以评价斑块性质及冠脉狭窄严重程度。
Abstract:
Aim:To explore the value of plasma lipoproteinassociated phospholipase A2(LPPLA2) level for predicting coronary atherosclerosis severity and risk of adverse events.Methods:Fortyfive patients with acute atherosclerotic syndrome(ACS) and thirtyfive patients with stable angina(SA) were examined by QCA and IVUSVH,and the LPPLA2 level in plasma was also detected by ELISA.Results:The percentages of necrotic core and dense calcium tissue in atherosclerotic plaques of ACS group were significantly higher than those of SA group(t=5.655,10.974,P<0.001).Coronary artery pathological change of ACS group was mainly positive remodeling,while SA group was mainly negative remodeling(χ2=40555,P<0.001).At the same time,the plasma LPPLA2 level of ACS group was significantly higher than that of SA group(t=2.934,P=0.004).With the rising of Gensini Scores,the plasma level of LPPLA2 increased gradually in ACS group and SA group(F=4.227,3.783,P<0.05).There was a significant positive correlation between the percentage of necrotic core and LPPLA2 level in plasma(r=0.439,P=0.003).Conclusion:The plasma level of LPPLA2 can be used for assessing the characteristics of the plaques and the severity of coronary artery stenosis.

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备注/Memo

备注/Memo:
#通讯作者,男,1957年7月生,硕士,主任医师,研究方向:冠心病的诊治,Email:Lxinhua321@163.com
更新日期/Last Update: 2013-04-19