[1]彭方慧,王峰,何炜,等.替吉奥与5氟尿嘧啶联合奈达铂治疗晚期食管癌的疗效比较*[J].郑州大学学报(医学版),2013,(02):160.
 PENG Fanghui,WANG Feng,HE Wei,et al.Comparison of clinical efficacy of advanced esophageal cancer treated with S1 and 5fluorouracil combined with nedaplatin[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(02):160.
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替吉奥与5氟尿嘧啶联合奈达铂治疗晚期食管癌的疗效比较*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年02期
页码:
160
栏目:
食管癌研究
出版日期:
2013-03-20

文章信息/Info

Title:
Comparison of clinical efficacy of advanced esophageal cancer treated with S1 and 5fluorouracil combined with nedaplatin
作者:
彭方慧王峰何炜樊青霞#
郑州大学第一附属医院肿瘤科 郑州 450052
Author(s):
PENG FanghuiWANG FengHE Wei FAN Qingxia
Department of Oncology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
替吉奥5氟尿嘧啶奈达铂晚期食管癌
Keywords:
S15fluorouracilnedaplatinadvanced esophageal cancer
分类号:
R735.1
摘要:
目的:比较替吉奥与5氟尿嘧啶联合奈达铂治疗晚期食管癌的效果。方法:收集80例晚期食管癌患者,分为替吉奥联合奈达铂治疗组(A组,40例)和5氟尿嘧啶联合奈达铂治疗组(B组,40例)。A组替吉奥胶囊每天80 mg/m2,分2次,餐后口服,第1~14天;服用14 d后停药7 d;奈达铂80 mg/m2,静脉滴注,第1天。B组奈达铂80 mg/m2,静脉滴注,第1天;5氟尿嘧啶1 000 mg/m2,静脉滴注,第1~5天;亚叶酸钙100 mg,第1~5天,静脉滴注。21 d为1个周期。比较2组患者的疗效、不良反应及生存期的差异。结果:2组患者总有效率(χ2=0.051,P=0.822)和临床获益率(χ2=0.092,P=0.762)差异均无统计学意义。A组患者中位生存时间为9.9个月,B组为9.6个月(χ2= 0.335,P=0.563)。A组患者中位肿瘤进展时间为6.8个月,B组为6.5个月(χ2=1.274,P=0.259)。结论:替吉奥联合奈达铂组治疗晚期食管癌疗效与5氟尿嘧啶联合奈达铂组差异无统计学意义,但不良反应较轻。
Abstract:
Aim: To compare the clinical efficacy of advanced esophageal cancer treated with S1 and 5fluorouracil combined with nedaplatin. Methods: Eighty patients with advanced esophageal cancer were randomly divided into S1 combined with Nedaplatin treatment group (group A) and 5fluorouracil combined with Nedaplatin treatment group (group B).The constituent ratio of the two groups' age,gender,and staging had no significant differences. The group A administered with a dose of 80mg/m2 S1 given orally twice a day from days 1 through 14, plus Nedaplatin at a dose of 80 mg/m2 by intravenous infusion on day 1; The group B administered with Nedaplatin at a dose of 80 mg/m2 given by intravenous infusion on day 1, plus 5fluorouracil at a dose of 1 000 mg/m2 and CF 100 mg/m2 by intravenous infusion on days 1 and 5. Three weeks was a cycle and compared to the differences of the two groups in treatment effect, adverse reaction, and survival time. Results: The total effective rate(χ2=0.051,P=0.822)and clinical benefit rate (χ2=0.092,P=0.762)had no significant differences in the two groups. In group A and in group B,the median survival time was respective 9.9 months and 9.6 months(χ2=0.335,P=0.563),the median time to tumor progression was 6.8 months and 6.5months (χ2=1.274,P =0.259).Adverse effects and serious adverse reactions in group A were significantly lower than in group B. Conclusion: The clinical efficacy of advanced esophageal cancer treated with S1 with Nedaplatin compared control group had no significant differences, but adverse effects were milder.

参考文献/References:

[1]王立东,宋昕.环境和遗传因素交互作用对食管癌发生的影响[J].郑州大学学报:医学版,2011,46(1):1
[2]高峰.食管癌研究现状综述[J].蚌埠医学院学报,2010,35(6):645
[3]王立东,任景丽,宋昕,等.食管癌变过程中肿瘤相关蛋白的表达[J].郑州大学学报:医学版,2009,44(1):13
[4]蒋庆锋,王国磊,张瑞祥,等.食管癌综合治疗的现状[J].肿瘤基础与临床,2010,23(1):88
[5]谢春强.晚期食管癌内科治疗的探索[J].中国实用医药,2012,7(21):79
[6]季言俊.奈达铂联合低剂量氟尿嘧啶持续静脉输注治疗老年食管癌32例疗效观察[J].内蒙古中医药,2010,29(2):70
[7]刘伟先,赵靓,刘晶,等.替吉奥联合奥沙利铂治疗晚期大肠癌的疗效观察[J].实用临床医药杂志,2010,14(24):54
[8]Eisenhauer EA, Therasse P, Bogaerts J,et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)[J]. Eur J Cancer, 2009, 45(2):228
[9]孙燕,石远凯.临床肿瘤内科手册[M].5版.北京:人民卫生出版社,2007:142
[10]黄文波,金常光. 奈达铂联合氟尿嘧啶治疗36 例晚期食管癌临床观察[J].中国现代药物应用,2012,6(3):62
[11]朱炜.术前新辅助化疗与单纯手术对可切除食管癌疗效的Meta分析[J].解放军医学杂志,2011,36(8):813
[12]Tanaka Y, Yoshida K, Osada S, et al. Docetaxel, nedaplatin, and S1 (DGS) chemotherapy for advanced esophageal carcinoma: a phase I doseescalation study[J]. Anticancer Res,2011,31(12):4589
[13]Koizumi W, Narahara H, Hara T, et al.S1 plus cisplatin versus S1 alone for firstline treatment of advanced gastric cancer (SPIRITS trial):a phase.Ⅲ trial[J].Lancet Oncol, 2008,9(3): 215

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备注/Memo

备注/Memo:
*河南省科技厅科技攻关基金资助项目072102310054#通讯作者,女,1952年6月生,本科,主任医师,研究方向:食管癌防治的基础与临床,Email: fqx2243@yahoo.com.cn
更新日期/Last Update: 2013-04-19