[1]李晓菲),余祖江),梁红霞),等.艾滋病患者抗病毒督导治疗疗效分析*[J].郑州大学学报(医学版),2013,(02):235.
 LI Xiaofei),YU Zujiang),LIANG Hongxia),et al.Analysis on effects of HAART from 377 Chinese AIDS[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(02):235.
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艾滋病患者抗病毒督导治疗疗效分析*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年02期
页码:
235
栏目:
应用研究
出版日期:
2013-03-20

文章信息/Info

Title:
Analysis on effects of HAART from 377 Chinese AIDS
作者:
李晓菲1)余祖江2)梁红霞2)何云3)江河清 2)阚全程1)
1)郑州大学第一附属医院药剂科 郑州 4500522)郑州大学第一附属医院感染科 郑州 4500523)郑州市第六人民医院 郑州 400050
Author(s):
LI Xiaofei1) YU Zujiang2) LIANG Hongxia1) HE Yun3) JIANG Heqing1) KAN Quancheng1)
1)Department of Pharmacology,the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052 2)Department of Infectious Disease,the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052 3)The 6th People's Hospital of Zhengzhou City, Zhengzhou 450050
关键词:
人类免疫缺陷病毒高效逆转录病毒治疗耐药
Keywords:
human immunodeficiency virushighly active antiretroviral therapyresistance
分类号:
R512.91
摘要:
目的: 探讨提高抗病毒疗效和服药依从性,延缓病毒耐药发生的方法。 方法: 377名来源于同一乡村的HIV感染者,分为督导治疗组(n=134)和未督导治疗组(n=243),均给予HAART治疗,仅督导治疗组患者给予严格督导治疗。分别于治疗后第1、2、3、6、9和12个月,抽取外周血,应用PCR检测HIVRNA载量,流式细胞仪检测CD4+、CD8+T淋巴细胞数量,血常规检测白细胞数量变化。 结果: 随着治疗时间的延长,2组患者外周血CD4+、CD8+T淋巴细胞及白细胞数量均逐渐上升;2组间比较,差异无统计学意义。2组患者外周血HIVRNA载量差异有统计学意义(F组间= 3.781,F时间=2.561,F交互=352.79,P﹤0.05);治疗后6、9和12个月督导治疗组高于未督导治疗组。 结论: 督导治疗有利于持续抗病毒疗效,延缓耐药毒株的发生。
Abstract:
Aim:To seek the suitable method for elevating the effects of HAART and delaying the emergence of the resistance.Methods: 377 AIDS patients from the same area were divided into the full supervision (n=134) and nonfull supervision (n=134) treatment groups. All the patients were given the same HAART traerment for 12 months. At 1,2,3,6,9,12 months after treatment, the HIVRNA load were detected by PCR , CD4+, CD8+ T cells were detected by flow cytometry , and white blood cell (WBC) were detected by routine blood test. Results: The counts of CD4+ ,CD8+ T cells elevated in the two groups ,and there were no obviously different.The HIVRNA load between the two groups were different(Fgroup=3.781, Ftime=2.561, Finteraction=352.791,P<0.05) ; Nonfull supervision treatment group was higher than the full supervision treatment group at 6,9,12 months after treatment.Conclusion: The full supervision treatment could delay the emergence of resistance and prolong the effect of HAART.

参考文献/References:

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备注/Memo

备注/Memo:
*国家“十·五”攻关课题基金资助项目200413A719A1305,200413A719A10;国家自然科学基金资助项目30472031#通讯作者,男,1963年5月生,博士,主任药师,研究方向:药学及免疫学,Email :johnyue1970@yahoo.com
更新日期/Last Update: 2013-04-19