[1]陈丹丹),刘媛),姬旭慧),等.原发性肝癌发病影响因素的病例对照研究*[J].郑州大学学报(医学版),2013,(02):249.
 CHEN Dandan),LIU Yuan),JI Xuhui),et al.A casecontrol study on influencing factors of primary hepatic carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(02):249.
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原发性肝癌发病影响因素的病例对照研究*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年02期
页码:
249
栏目:
应用研究
出版日期:
2013-03-20

文章信息/Info

Title:
A casecontrol study on influencing factors of primary hepatic carcinoma
作者:
陈丹丹1)刘媛1)姬旭慧1)张玲2)黄长山2)崔宏2)吕全军1)#
1)郑州大学公共卫生学院营养与食品卫生学教研室 郑州 4500012)河南省肿瘤医院肝胆外科 郑州 450008
Author(s):
CHEN Dandan1)LIU Yuan1) JI Xuhui1) ZHANG Ling2)HUANG Changshan2)CUI Hong2)LV Quanjun1)
1)Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 4500012)Department of Hepatobiliary and Pancreatic Surgery, Henan Tumor Hospital, Zhengzhou 450008
关键词:
原发性肝癌危险因素病例对照研究
Keywords:
primary hepatic carcinoma risk factor casecontrol study
分类号:
R153.9
摘要:
探讨原发性肝癌的主要危险因素,为肝癌的病因预防和人群预防提供依据。方法:以2009年4月至2011年11月在河南省肿瘤医院住院的原发性肝癌患者323例和同时期住院的其他非肝癌患者443例为对象进行病例对照研究,经过单因素和多因素非条件logistic回归分析筛选出原发性肝癌发病的影响因素。结果:多因素非条件logistic回归分析结果表明:男性中, HBV感染、吸烟、剩饭菜、腌制食品、饮酒、饮茶、蔬菜的OR值及95%CI分别为33.532(13.943~80.644,P<0.001)、4.180(1.808~9.667,P=0.001)、4.173(2.205~7.901,P<0.001)、2.915(1.178~7.218,P=0.021)、1.378(1.011~1.878,P=0.042)、0.199(0.075~0.525,P=0.001)、0.053(0.026~0.106,P<0.001);女性中,HBV 感染、饮酒、油多的饭菜、剩饭菜、文化程度、蔬菜、饮茶的OR值及95%CI分别为41.949(8.548~205.857,P<0.001)、37.012(1.266~108.246,P=0.036)、5.375(1.297~22.271,P=0.020)、4.254(1.727~10.480,P=0.002)、0.098(0.029~0.334,P<0.001)、0.011(0.002~0.055,P<0.001)、0.010(0.001~0.194,P=0.002)。结论:HBV感染、吸烟、饮酒、吃剩饭菜、吃腌制食品及油多的饭菜可能是肝癌发生的危险因素;高文化程度、常吃蔬菜、饮茶是肝癌发生的保护因素。
Abstract:
Aim:To investigate the main risk factors of primary hepatic carcinoma and provide evidences for causes prevention and population prevention and control. Methods: A total of 323 cases of primary hepatic carcinoma and 443 cases of nonliver diseases were sampled that hospitalized in Henan Tumor Hospital from April 2009 to November 2011. Then a casecontrol study was carried out. The nonconditional logistic regression model was used for single factor analysis and multivariate analysis. Results:The results of multivariate analysis showed that, for male, the OR values and 95%CI of HBV infection, smoking, eating the leftovers, eating salted food, drinking alcohol, drinking tea, and eating vegetables were 33.532(13.943~80.644,P<0.001), 4.180(1.808~9.667,P=0.001), 4.173(2.205~7.901,P<0.001), 2.915(1.178~7.218,P=0.021), 1.378(1.011~1.878,P=0.042), 0.199(0.075~0.525,P=0.001), and 0.053(0.026~0.106,P<0.001). For female, the OR values and 95%CI of HBV infection, drinking alcohol, taking in more oil from meals, eating the leftovers, cultural level, eating vegetables, and drinking tea were 41.949(8.548~205.857,P<0.001), 37.012(1.266~108.246,P=0.036), 5.375(1.297~22.271,P=0.020), 4.254(1.727~10.480,P=0.002), 0.098(0.029~0.334,P<0.001), 0.011(0.002~0.055,P<0.001),and 0.010(0.001~0.194,P=0.002).Conclusion:The HBV infection, smoking, drinking alcohol, eating the leftovers, eating salted food, and taking in more oil from meals may be risk factors of primary hepatic carcinoma; high cultural level,eating vegetables,and drinking tea may be protective factors.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目30771099;科技重大专项“十一·五”计划基金资助项目2009ZX10004903#通讯作者,男,1962年10月生,博士,教授,研究方向:营养与疾病,Email:lqjnutr@zzu.edu.cn
更新日期/Last Update: 2013-04-19