[1]朱涛#,许军秀,徐明.充血性心力衰竭患者血清sICAM1及白细胞膜黏附分子水平检测[J].郑州大学学报(医学版),2013,(02):260.
 ZHU Tao,XU Junxiu,XU Ming.Serum levels of soluble intercellular adhesion molecule1 and leukocyte membrane adhesion molecules in patients with congestive heart failure[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(02):260.
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充血性心力衰竭患者血清sICAM1及白细胞膜黏附分子水平检测
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年02期
页码:
260
栏目:
应用研究
出版日期:
2013-03-20

文章信息/Info

Title:
Serum levels of soluble intercellular adhesion molecule1 and leukocyte membrane adhesion molecules in patients with congestive heart failure
作者:
朱涛#许军秀徐明
郑州大学第五附属医院检验科 郑州 450052
Author(s):
ZHU TaoXU JunxiuXU Ming
Clinical Laboratory,the Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
充血性心力衰竭可溶性细胞间黏附分子1白细胞膜黏附分子
Keywords:
congestive heart failuresoluble intercellular adhesion molecule1leukocyte membrane adhesion molecule
分类号:
R541.6
摘要:
分析充血性心力衰竭(CHF)患者血清可溶性细胞间黏附分子1(sICAM1)及白细胞膜黏附分子(CD11a和CD18)水平的变化。方法:采集80例CHF患者和50例健康对照者血清标本,采用ELISA法进行血清sICAM1检测,采用流式细胞仪检测CD11a和CD18。结果:CHF患者血清sICAM1水平及CD11a、CD18阳性细胞百分率高于对照组(t分别为10.186、11.999和13.764,P均<0.05)。不同基础心脏病CHF患者上述指标差异均无统计学意义(F=2.578、1.723、0.214,P均>0.05),不同心功能分级CHF患者间血清sICAM1水平,CD11a、CD18阳性细胞百分率差异均有统计学意义(F=23.953、15.592和25.384,P<0.001),Ⅳ级患者高于Ⅱ、Ⅲ级患者(P<0.05)。结论:ICAM1介导的心脏炎症反应可能是诱发或加重CHF的原因之一。
Abstract:
Aim:To determine the serum levels of soluble intercellular adhesion molecule1(sICAM1) and leukocyte membrane adhesion molecules(CD11a and CD18) in patients with congestive heart failure(CHF).Methods:The serum specimens of eighty patients with CHF and fifty healthy controls were collected.The serum sICAM1 was determined by ELISA,and CD11a and CD18 by flow cytometry.Results:The serum sICAM1 level and the percent of CD11a+ or CD18+ cells of CHF patients were significantly higher than those of the control group(t=10.186,11.999,and 13.764,P<0.05).Among the CHF patient caused by different heart disease,there were no significant differences in the serum sICAM1 level and the percent of CD11a+ or CD18+ cells(F=2.578,1.723,0.214,P>0.05).There were significant differences in the serum sICAM1 level,the percent of CD11a+ and CD18+cells(F=23.953,15.592,25.384,P<0.001) among the CHF patients with different heart function degree,and those of Ⅳ degree CHF patients were higher than those of Ⅱ or Ⅲ degree patients(P<0.05).Conclusion:The inflammation reaction induced by ICAM1 may be important for CHF.

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备注/Memo

备注/Memo:
#通讯作者,男,1968年10月生,本科,副主任技师,研究方向:免疫微生物,Email:taotao010608@sina.com
更新日期/Last Update: 2013-04-19