[1]岳新新),薛蕊),张炜),等.侵袭性牙周炎患者牙龈组织中MMP8及TIMP1的表达*[J].郑州大学学报(医学版),2013,(03):366.
 YUE Xinxin),XUE Rui),ZHANG Wei),et al.Expressions of MMP8 and TIMP1 in gingival tissue of patients with aggressive periodontitis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(03):366.
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侵袭性牙周炎患者牙龈组织中MMP8及TIMP1的表达*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年03期
页码:
366
栏目:
应用研究
出版日期:
2013-06-20

文章信息/Info

Title:
Expressions of MMP8 and TIMP1 in gingival tissue of patients with aggressive periodontitis
作者:
岳新新1)薛蕊2)张炜2)刘娟1)轩东英1)章锦才1)赵红宇3)#
1)南方医科大学附属口腔医院;广东省口腔医院牙周科 广州 510280
2)郑州大学口腔医学院 郑州 450052
3)南方医科大学附属口腔医院;广东省口腔医院番禺分院牙周科 番禺 511400
Author(s):
YUE Xinxin1) XUE Rui2) ZHANG Wei2)LIU Juan1) XUAN Dongying1) ZHANG Jincai1)ZHAO Hongyu3)
1)Department of Periodontology, Guangdong Provincial Stomatological Hospital;the Affiliated Stomatological Hospital,Southern Medical University, Guangzhou 510280
2)School of Stomatology,Zhengzhou University, Zhengzhou 450052
3)Department of Periodontology, Panyu Branch,Guangdong Provincial Stomatological Hospital;the Affiliated Stomatological Hospital,Southern Medical University, Panyu 511400
关键词:
侵袭性牙周炎基质金属蛋白酶基质金属蛋白酶抑制因子
Keywords:
aggressive periodontitismatrix metalloproteinasetissue inhibitor of metalloproteinase
分类号:
R781.4
摘要:
摘要目的:探讨基质金属蛋白酶8(MMP8)及其抑制因子1 (TIMP1)在侵袭性牙周炎(AgP)牙龈组织中的表达情况。方法:采用免疫组织化学方法检测15例AgP患者和20例对照的牙龈组织中MMP8和TIMP1蛋白的表达情况。结果:MMP8和TIMP1在2组牙龈组织的上皮内及上皮下结缔组织中均有表达。AgP组MMP8表达水平和MMP8/TIMP1均高于对照组(Z=2.990和4.911,P<0.05),2组TIMP1的表达差异无统计学意义(Z=1.822,P>0.05)。ROC曲线分析结果显示,AUC(MMP8)=0.752(95%CI=0.618~0.885,P=0.003), AUC(MMP8/TIMP1)=0.913(95%CI=0.831~0.996,P<0.001),AUC(TIMP1)=0.347(95%CI=0.194~0.499,P=0.068)。结论: 牙龈组织中MMP8表达水平和MMP8/TIMP1可以作为诊断AgP的潜在指标。
Abstract:
AbstractAim: To study the expression of matrix metalloproteinase8(MMP8) and its inhibitory factor1(TIMP1) in gingival tissue of patients with aggressive periodontitis(AgP).Methods: Immunohistochemistry method was used to detect MMP8 and TIMP1 protein in gingival tissue of 15 AgP patients and 20 healthy control.Results: MMP8 and TIMP1 were positively expressed in the intraepithelial and subcutaneous connective tissue in both groups. MMP8 expression level and MMP8/TIMP1 of AgP group were significantly higher than those of the control group (Z=2.990 and 4.911,P<0.05), but the difference in TIMP1 expression between the 2 groups was not significant (Z=1.822,P>0.05). ROC curve analysis showed that AUC(MMP8)=0.752(95%CI=0.618-0.885,P=0.003), AUC(MMP8/TIMP1)=0.913(95%CI=0.831-0.996, P<0.001),AUC(TIMP1)=0.347(95%CI=0.194-0.499,P=0.068). Conclusion: MMP8 expression level and MMP8/TIMP1 in gingival tissue could be helpful for the diagnosis of AgP.

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备注/Memo

备注/Memo:
*广东省科技计划项目00204390134483040
#通讯作者,女,1965年7月生,教授,主任医师,研究方向:牙周疾病的病因学及治疗, Email:zhongyu93@163.com
更新日期/Last Update: 2013-07-03