[1]苏慧东,王瑞华,孙珂,等.SPECT/CT显像和甲状腺球蛋白检测对分化型甲状腺癌转移的预测价值*[J].郑州大学学报(医学版),2013,(03):381.
 SU Huidong,WANG Ruihua,SUN Ke,et al.Value of SPECT/CT scan and serum thyroglobulin in predicting metastasis for patients with differentiated thyroid carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(03):381.
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SPECT/CT显像和甲状腺球蛋白检测对分化型甲状腺癌转移的预测价值*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年03期
页码:
381
栏目:
应用研究
出版日期:
2013-06-20

文章信息/Info

Title:
Value of SPECT/CT scan and serum thyroglobulin in predicting metastasis for patients with differentiated thyroid carcinoma
作者:
苏慧东王瑞华孙珂闫志华阮翘刘保平韩星敏#
郑州大学第一附属医院核医学科;河南省高等学校临床医学重点学科开放实验室 郑州 450052
Author(s):
SU Huidong WANG Ruihua SUN Ke YAN Zhihua RUAN Qiao LIU BaopingHAN Xingmin
Department of Nuclear Medicine, the First Affiliated Hospital, Zhengzhou University; the Open Key Clinical Medical Experimental Laboratory Institute of Universities of Henan Province,Zhengzhou 450052
关键词:
131ISPECT/CT断层融合成像甲状腺肿瘤转移灶
Keywords:
131I SPECT/CThybrid imagingthyroid carcinomametastasis
分类号:
R817
摘要:
摘要目的:评价分化型甲状腺癌(DTC)术后首次131I去除治疗5 d后SPECT/CT显像(首次显像)和血清甲状腺球蛋白(Tg)水平在预测6个月后颈、胸部的摄131I转移灶中的价值。方法:120例DTC患者术后首次131I去除治疗前测Tg水平,去除治疗5 d后行SPECT/CT显像,6个月后复查SPECT/CT显像(复查显像)和测Tg水平,比较2次显像颈、胸部摄131I转移灶的变化。结果:首次显像未见摄131I转移灶患者100例(A组),复查显像发现有摄131I转移灶患者6例(阳性率6.0%)。Tg<10 μg/L者59例(A1组),其中1例复查显像发现摄131I转移灶(阳性率1.7%);Tg≥10 μg/L患者41例(A2组),其中5例复查显像发现摄131I转移灶(阳性率12.2%)。首次显像有摄131I转移灶患者20例(B组),复查显像7例仍有摄131I转移灶(阳性率35.0%)。Tg<10 μg/L者9例(B1组),其中1例复查显像发现摄131I转移灶(阳性率11.1%);Tg≥10 μg/L者11例(B2组),其中6例复查显像仍有摄131I转移灶(阳性率54.6%)。A组和B组复查显像阳性率差异有统计学意义(校正χ2 =11.664,P=0.001),A1组和A2组,B1组和B2组两两组间复查显像阳性率差异均无统计学意义(P>0.05)。结论:DTC术后首次131I去除治疗5 d后SPECT/CT显像对预测6个月后颈、胸部的摄131I转移灶有一定价值。
Abstract:
AbstractAim:To investigate the value of first posttherapy 131ISPECT/CT scan and serum thyroglobulin (Tg) level in predicting the cervical and thoracic radioiodinepositive metastases 6 months later for patients with differentiated thyroid carcinoma. Methods:The study included 120 DTC patients that had determined the serum lever of Tg and had accepted SPECT/CT after radioablation of thyroid remnants after thyroidectomy. The patients were reexamined 6 months later at TSH stimulation. Results:Out of 100 patients without SPECT/CT diagnosis of 131I positive metastases at first radioablation (group A),6 patients were detected having radioiodinepositive metastases at follow up(6.0%). Out of 59 patients who had Tg<10 μg/L (group A1), only 1 patient was detected having a new radioiodinepositive metastasis at follow up (1.7%); Out of 41 patients who had Tg≥10 μg/L (group A2), 5 patients were detected having new radioiodinepositive metastases at follow up (12.2%);Out of 20 patients with SPECT/CT diagnosis of 131I positive metastases at first radioablation (group B), 7 patients were detected having radioiodinepositive metastases at follow up (35.0%). Out of 9 patients who had Tg<10 μg/L(group B1), only one was detected having a new radioiodinepositive metastasis at follow up (11.1%); out of 11 patients who had Tg≥10 μg/L(group B2), 6 patients persisted in radioiodinepositive metastases at follow up (54.6%). Chisquare test showed that the difference between group A and B was significant(χ2 adj=11.664,P=0.001),the differences between group A1 and A2,B1 and B2 were not significant(P>0.05).Conclusion:The first posttherapy 131ISPECT/CT scan is useful to predict the occurrence and/or persistence of cervical and thoracic radioiodinepositive metastases 6 months later.

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备注/Memo

备注/Memo:
*河南省教育厅科学技术研究重点基金资助项目13B320357
#通讯作者,男,1965年12月生,硕士,教授,研究方向:肿瘤核医学,Email:xmhan@zzu.edu.cn
更新日期/Last Update: 2013-07-03