[1]李娜,苗聪秀#,关素萍,等.冷冻胚胎移植失败高危因素的logistic回归分析[J].郑州大学学报(医学版),2013,(03):403.
 LI Na,MIAO Congxiu,GUAN Suping,et al.Logistic regression analysis of high risk factors in frozen embryo transplantation failure[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(03):403.
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冷冻胚胎移植失败高危因素的logistic回归分析
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年03期
页码:
403
栏目:
应用研究
出版日期:
2013-06-20

文章信息/Info

Title:
Logistic regression analysis of high risk factors in frozen embryo transplantation failure
作者:
李娜苗聪秀#关素萍毕慧玲韩丽娟刘锦宏
长治医学院附属和平医院生殖中心 长治 046000
Author(s):
LI NaMIAO CongxiuGUAN SupingBI HuilingHAN LijuanLIU Jinhong
Reproductive Medicine Center, the Affiliated Heping Hospital, Changzhi Medical College, Changzhi 046000
关键词:
冷冻胚胎高危因素logistic回归分析
Keywords:
frozen embryo high risk factor logistic regression analysis
分类号:
R711.6
摘要:
摘要目的:探讨导致冷冻胚胎移植失败的高危因素。方法:对2009年5月至2012年5月在长治医学院附属和平医院生殖中心接受冷冻胚胎移植的328例患者的相关资料进行回顾性分析。根据患者是否成功临床妊娠分为妊娠组(107例)和未妊娠组(221例)。对年龄、不孕时间、不孕原因、冻融方法、胚胎发育时间、胚胎等级、子宫内膜准备方法、子宫内膜厚度、激素水平(雌激素/孕激素,E2/P)、受精方式、移植位置(移植胚胎到宫底的距离/宫颈内口到宫底的距离,DA/DB)11个因素进行分析,用logistic回归模型筛选冷冻胚胎移植失败的高危因素。结果:妊娠组与未妊娠组的年龄(t=3.908,P<0.001)、冻融方法(χ2=10.239,P<0.001)、胚胎等级(χ2=9.853,P=0.002)、子宫内膜厚度(χ2=77.556,P<0.001)、激素水平(χ2=39.265,P<0.001)、移植位置(χ2=12.395,P=0.002)比较,差异有统计学意义。Logistic回归分析结果显示年龄(P=0.026)、冻融方法(P=0.005)、胚胎等级(P<0.001)、子宫内膜厚度(P=0.026)与妊娠结局有关,其OR值(95%CI)分别为0.537(0.310~0.929)、0.472(0.279~0.798)、0.221(0.108~0.455)和0.654(0.451~0.950)。结论:高龄、胚胎质量不佳、子宫内膜容受性差是导致冷冻胚胎移植失败的独立高危因素。
Abstract:
AbstractAim: To explore the high risk factors in frozen embryo transplantation failure. Methods: The related data of 328 patients who accepted frozen embryo transplantation were retrospectively analyzed. Patients were divided into pregnancy group (n=107) and nonpregnancy group (n=221). Age, duration of infertility, causes of infertility, frozen method, embryonic development time, embryo grade, endometrial preparation method, endometrial thickness, hormone level (estrogen/progesterone, E2/P), insemination way, and transplantation position (DA/DB) were analyzed. The high risk factors were screened using logistic regression model. Results: The differences of age(t=3.908, P<0.001), frozen method(χ2=10.239, P<0.001), embryo grade(χ2=9.853, P=0.002), endometrial thickness(χ2=77.556, P<0.001), hormone level(χ2=39.265, P<0.001) and transplantation position (χ2=12.395, P=0.002) between pregnancy group and nonpregnancy group were significant. Logistic regression analysis results displayed that age(P=0.026), frozen method(P=0.005), embryo grade(P<0.001), endometrial thickness(P=0.026) were related to pregnancy outcome,and OR(95%CI) were 0.537(0.310-0.929),0.472(0.279-0.798),0.221(0.108-0.455) and 0.654(0.451-0.950). Conclusion: Advanced age, poor embryo quality and bad endometrial receptivity are the independent high risk factors which lead to the failure of frozen embryo transplantation.

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备注/Memo

备注/Memo:

#通讯作者,男,1965年1月生,博士,副教授,研究方向:生殖与遗传,Email:mcxms@163.com
更新日期/Last Update: 2013-07-03