[1]王睿丽),范闽延),罗穗豫),等.多普勒超声对妊娠滋养细胞肿瘤疗效评估的价值[J].郑州大学学报(医学版),2013,(03):417.
 WANG Ruili),FAN Minyan),LUO Suiyu),et al.Assessment of Doppler ultrasonography for chemotherapy effect of gestational trophoblastic neoplasm[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(03):417.
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多普勒超声对妊娠滋养细胞肿瘤疗效评估的价值
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年03期
页码:
417
栏目:
应用研究
出版日期:
2013-06-20

文章信息/Info

Title:
Assessment of Doppler ultrasonography for chemotherapy effect of gestational trophoblastic neoplasm
作者:
王睿丽12)范闽延1) 罗穗豫3)程佳2)袁建军1)#
1)郑州大学第一附属医院超声科 郑州 450052
2)河南省人民医院超声科 郑州 450003
3)河南省人民医院妇产科 郑州 450003
Author(s):
WANG Ruili12)FAN Minyan1)LUO Suiyu3) CHENG Jia2)YUAN Jianjun1)
1)Department of Ultrasonic,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
2)Department of Ultrasonic, Henan Provincial Peoples Hospital,Zhengzhou 450003
3)Department of Gynecology and Obstetrics,Henan Provincial Peoples Hospital,Zhengzhou 450003
关键词:
多普勒超声妊娠滋养细胞肿瘤疗效评估
Keywords:
Doppler ultrasoundgestational trophoblastic neoplasm therapeutic effect assessment
分类号:
R737.3
摘要:
摘要目的:探讨多普勒超声(DUS)对妊娠滋养细胞肿瘤(GTN)疗效评估的价值。方法:回顾性分析44例GTN患者化疗前后及随访期间血清绒毛膜促性腺激素(βHCG)水平、子宫结构及多普勒血流阻力指数(RI)的变化。结果:44例化疗前DUS表现为宫旁病变1例,弥漫型5例,局限型38例;局限型病例病灶直径为(4.38±1.55) cm,44例RI 为(0.30±0.06),较对照组的(0.65±0.04)明显降低(t=27.963,P<0.001)。化疗结束病灶消失后原病灶区血流RI为(0.64±0.04),与对照组比较,差异无统计学意义(t=1.029,P=0.307)。随访8~30 个月,1例化疗无效子宫切除,余43例化疗有效,血清βHCG转阴。宫壁异常回声消失与血清βHCG转阴同步者27例,宫壁异常回声延迟消失14例,残余病灶切除1例,失访1例。结论:DUS对GTN的随访与疗效评估有重要的临床价值。
Abstract:
AbstractAim: To assess the value of Doppler ultrasonography(DUS) for chemotherapy effect of gestational trophoblastic neoplasm(GTN).Methods:A retrospective analysis of 44 cases of GTN was performed with the examination of serum beta human chorionic gonadotropin(βHCG),uterine structure, and Doppler resistance index (RI) before and after chemotherapy and during the followup. Results: DUS showed that one case had parauterine lesion and others had uterine structure changes including 5 with diffuse type and 38 with limited form; the diameter of lumps of the limited form was (4.38±1.55) cm, and RI of 44 cases was (0.30±0.06) before chemotherapy, which was lower than that[ (0.65±0.04)] of the normal control(t=27.963,P<0.001). RI was (0.64±0.04) after chemotherapy,which was similar to the normal control(t=1.029,P=0.307). During the followup, one case accepted hysterectomy, and other 43 cases got negative serum βHCG; 27 cases pelvis structure recovered with negative serum βHCG,14 cases pelvis structure changes delayed. Conclusion: DUS is useful in estimating the chemotherapy effect of GTN.

参考文献/References:

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[3]万小云,石一复.妊娠滋养细胞肿瘤的子宫血管结构[J].中华妇产科杂志,1997,32(3):56
[4]隋秀芳,李美光,赵志宏,等.彩色多普勒血流显像对恶性滋养细胞肿瘤的应用价值[J].中国超声诊断杂志,2006,7(6):446
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备注/Memo

备注/Memo:

#通讯作者,男,1960年8月生,博士,主任医师,研究方向:超声诊断
更新日期/Last Update: 2013-07-03