[1]李永丽,闫峰山,窦社伟,等.动脉质子自旋标记与动态磁敏感对比增强法灌注成像在评价脑缺血患者脑部微循环中的临床对比应用*[J].郑州大学学报(医学版),2013,(04):517.
 LI Yongli,YAN Fengshan,DOU Shewei,et al.Comparison of arterial spin labeling and dynamic susceptibility contrastenhanced perfusion weighted imaging in evaluating microcirculation of patients with cerebral ischemia[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(04):517.
点击复制

动脉质子自旋标记与动态磁敏感对比增强法灌注成像在评价脑缺血患者脑部微循环中的临床对比应用*
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年04期
页码:
517
栏目:
应用研究
出版日期:
2013-07-20

文章信息/Info

Title:
Comparison of arterial spin labeling and dynamic susceptibility contrastenhanced perfusion weighted imaging in evaluating microcirculation of patients with cerebral ischemia
作者:
李永丽 闫峰山 窦社伟 连建敏 徐俊玲 王梅云#
河南省人民医院放射科 郑州 450003
Author(s):
LI Yongli YAN Fengshan DOU Shewei LIAN Jianmin XU Junling WANG Meiyun
Department of Radiology,Henan Provincial Peoples Hospital, Zhengzhou 450003
关键词:
动脉质子自旋标记 动态磁敏感对比增强 磁共振成像脑缺血灌注
Keywords:
arterial spin labelingdynamic susceptibility contrastenhanced perfusion weighted imaging magnetic resonance imagingcerebral ischemiaperfusion
分类号:
R743.34
摘要:
目的:对比研究动脉质子自旋标记(ASL)与动态磁敏感增对比增强灌注成像(DSCPWI)在评价脑缺血患者脑部微循环中的应用。方法:一侧大脑中动脉明显狭窄或闭塞的脑缺血患者25例,均采用GED750 3.0T MR行头部ASL和DSCPWI 检查,定性观察两种技术在脑缺血中的灌注表现;在病变区域与正常脑半球的镜像区域分别确定4个感兴趣区,测定脑血流量(CBF)值,并计算信号强度比(病变侧/对照侧)。结果:25例患者中,ASL显示灌注不足19例,灌注过度1例,灌注正常5例,DSCPWI显示灌注不足14例,灌注过度1例,灌注延迟6例,灌注正常4例,两种方法结果一致19例,符合率为76.0%。ASL和DSCPWI所测相对CBF比值分别为(0.462±0.130)和(0.428±0.120),2组相比,差异无统计学意义(t=0.750, P=0.465)。结论:无创性ASL在检测脑缺血脑血流量灌注异常时与DSCPWI具有同样的敏感性。
Abstract:
Aim: To compare the clinical values of arterial spin labeling(ASL)and dynamic susceptibility contrastenhanced perfusion weighted imaging (DSCPWI) MRI in evaluating the brain microcirculation of patients with cerebral ischemia. Methods:A total of 25 cases of brain ischemia with unilateral middle cerebral artery stenosis were examined by GED750 3.0T MR, and ASL and DSCPWI data were acquired. Four regions of interest(ROI) in the lesion area and the mirror area of the lesions were chosen separately, the signal strength was measured, and the signal intensity ratio (lesion side/control side) was calculated. Results: In the 25 patients, there were 19 cases of hypoperfusion, 1 case of hyperperfusion, and 5 cases of normal perfusion according to ASL, and there were 14 cases of hypoperfusion, 1 case of hyperperfusion, 6 cases of delayed perfusion, and 4 cases of normal perfusion according to DSCPWI (19 cases were consistent,and the cosistent rate was 76.0%). Quantitative results showed that the signal intensity ratio was (0.462±0.130) for ASL, (0.428±0.120) for DSCPWI, and there was no significant difference between the 2 techniques(t=0.750, P=0.465). Conclusion: Noninvasive ASL perfusion is as sensitive as DSCPWI in detecting cerebral microcirculation.

参考文献/References:

[1]王梅云,戴建平,程敬亮,等.动脉血质子自旋标记与动态磁敏感对比MRI在急性脑缺血患者中的应用价值 [J].中华放射学杂志,2007,41(11):1162
[2]Lia TQ,Chen ZG,Ostergaard L,et al. Quantification of cerebral blood flow by bolus tracking and artery spin tagging methods [J].Magn Reson Imaging,2000,18(5):503
[3]范丽,陶晓峰,刘士远,等. ASL在中枢神经系统疾病诊断中的初步应用体会 [J]. 放射学实践,2007,22(7):675
[4]张丽雅,高志翔,周旭峰,等.MRA与ASL灌注联合评估TIA结果分析 [J]. 医学影像学杂志,2010,20(1):23
[5]Chalela JA, Alsop DC,GonzalezAtavales JB,et al.Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling [J].Stroke,2000,31(3):680
[6]Siewert B,Schlaug G,Edelman RR,et al. Comparison of EPISTAR and T2*weighted gadoliniumenhanced perfusion imaging in patients with acute cerebral ischemia [J]. Neurology,1997,48(3):673
[7]王建利,谢敬霞.对比增强磁共振脑血流灌注成像 [J] .临床放射学杂志,2000,19(3):184

备注/Memo

备注/Memo:
*河南省卫生科技攻关计划基金资助项目201003101 #通讯作者,女,1972年9月生,博士,主任医师,研究方向:中枢神经系统影像学研究,Email:marian9999@163.com
更新日期/Last Update: 2013-07-25