[1]张彬△,李欣,李金源,等.甲状腺功能状态对大鼠微种植体支抗即刻负载稳定性的影响*[J].郑州大学学报(医学版),2013,(04):520.
 ZHANG Bin,LI Xin,LI Jinyuan,et al.Stability of microimplant instant load in rats with different thyroid functional status[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(04):520.
点击复制

甲状腺功能状态对大鼠微种植体支抗即刻负载稳定性的影响*
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年04期
页码:
520
栏目:
应用研究
出版日期:
2013-07-20

文章信息/Info

Title:
Stability of microimplant instant load in rats with different thyroid functional status
作者:
张彬李欣李金源王旭明孟菲李儒
河北联合大学口腔医学院正畸科 唐山 063000
Author(s):
ZHANG Bin LI Xin LI Jinyuan WANG Xuming MENG Fei LI Ru
Department of Orthodontics, College of Stomatology, Hebei United University, Tangshan 063000
关键词:
甲状腺素即刻负载微种植体支抗骨结合率稳定性大鼠
Keywords:
thyroid hormoneinstant loadmicroimplantbone combining rate stability rat
分类号:
R783.5
摘要:
目的:观察不同甲状腺功能状态下即刻负载微种植体支抗的可行性及稳定性。方法:健康Wistar雌性大鼠30只,随机分成3组,每组10只。甲状腺功能亢进组(甲亢组)、甲状腺功能减低组(甲减组)和正常组分别给予优甲乐、丙基硫氧嘧啶和蒸馏水,均按0.01 mL/g体质量每天灌胃1次,28 d后植入微种植体并即刻持续负载0.98 N,加载30 d后处死动物。通过X线片测量微种植体支抗骨内移动间距;荧光显微镜下观察含微种植体超硬组织切片并计算骨矿化沉积率、骨结合率。 结果:3组微种植体支抗位移、骨结合率和骨矿化沉积率相比,差异均有统计学意义(F=11.825、39.953和20.045,P<0.05),其中甲亢组骨结合率和骨矿化沉积率最高,微种植体支抗位移最大,高于正常组和甲减组;甲减组以上指标均低于正常组(P<0.05)。结论:不同甲状腺功能状态下微种植体支抗即刻负载是可行的;甲状腺激素对微种植体支抗能力有影响,甲亢时微种植体支抗骨结合率最高,甲减时骨结合率最低。
Abstract:
Aim: To observe the stability and the feasibility of microimplant instant load on rats with different thyroid functional status.Methods: Thirty healthy female adult Wistar rats were allocated into 3 groups randomly,10 in each group.The hyperthyroid group was given euthyrox, the hypothyroidism group was given 0.1% propylthiouracil,and the normal group was given distilled water(all gavaged 0.01 mL/g weight every day).After 28 days, microimplants were implanted and then loaded 0.98 N force instantly, and the animals were sacrificed after 30 days. The separation distance of microimplants in the bone was measured by Xray and fluorescence microscopy was used to observe hard tissue slice including the implant. Finally, the bone mineralization deposition rate and bone combining rate were calculated.Results: Among the three groups, the differences in the separation distance, bone combining rate and the bone mineralization deposition rate of the microimplants were statistically significant(F=11.825,39.953 and 20.045,P<0.05).Hyperthyroid group had the highest bone mineralization deposition rate, bone combining rate,and the separation distance of the microimplants than the other 2 groups, and these parameters were the lowest in the hypothyroidism group(P<0.05).Conclusion: Microimplant instant load is feasible under different thyroid functional status; thyroid hormones have influence on the stability of microimplants, and the bone combining rate is the highest under hyperthyroid and it is the lowest under hypothyroidism.

参考文献/References:

[1]王计艳,邢学农,祝捷,等. 甲状腺功能亢进症与骨代谢相关性分析 [J]. 放射免疫学杂志,2012,25(3):247
[2]Feitosa Dda S, Bezerra Bde B, Ambrosano GM, et al. Thyroid hormones may influence cortical bone healing around titanium implants: a histometric study in rats [J]. J Periodontol, 2008, 79(5):881
[3]Huang LH, Shotwell JL, Wang HL. Dental implants for orthodontic anchorage [J]. Am J Orthod Dentofacial Orthop, 2005, 127(6): 713
[4]Deguchi T, TakanoYamamoto T, Kanomi R, et al. The use of small titanium screws for orthodontic anchorage [J]. J Dent Res, 2003,82(5):377
[5]Brunski JB. Avoid pitfalls of overloading and micromotion of intraosseous implants [J]. Dent Implantol Update, 1993, 4(10): 77
[6]Melsen B, Costa A. Immediate loading of implants used for orthodontic anchorage [J]. Clin Orthod Res, 2000, 3(1): 23
[7]熊国平, 孙昕, 张国志, 等. 国产微型钛钉正畸支抗即刻负载稳定性的实验研究 [J]. 中国口腔种植学杂志, 2006, 11(1): 13

相似文献/References:

[1]张月兰),曹选平)#,蔡留意),等.国产微螺钉种植体支抗即刻负载的稳定性观察*[J].郑州大学学报(医学版),2009,(04):748.
 ZHANG Yuelan),CAO Xuanping),CAI Liuyi),et al.Stabile observation of the microscrew implant after immediate loading[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):748.
[2]李冠娥),张彬)#,李金源),等.不同加载时机对低骨代谢大鼠微型种植体支抗稳定性的影响[J].郑州大学学报(医学版),2012,(02):194.
 LI Guaner),ZHANG Bin),LI Jinyuan),et al.Effects of different loading time on stability of microimplant anchorage in rats with low bone metabolism[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(04):194.

备注/Memo

备注/Memo:
*唐山市科技支撑项目08130219C 男,1965年8月生,本科,讲师,研究方向:口腔正畸学,Email:zhangbin3065@163.com
更新日期/Last Update: 2013-07-25