[1]杨万荷,李家群,仝亚林,等.血清CA199和血浆FIB水平在良、恶性梗阻性黄疸鉴别诊断中的价值*[J].郑州大学学报(医学版),2013,(05):661.
 YANG Wanhe,LI Jiaqun,TONG Yalin,et al.Differential diagnosis value of serum CA199 level combined with plasma FIB level between benign and malignant obstructive jaundice[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(05):661.
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血清CA199和血浆FIB水平在良、恶性梗阻性黄疸鉴别诊断中的价值*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年05期
页码:
661
栏目:
应用研究
出版日期:
2013-09-02

文章信息/Info

Title:
Differential diagnosis value of serum CA199 level combined with plasma FIB level between benign and malignant obstructive jaundice
作者:
杨万荷李家群仝亚林李林静李治国冯百岁#
郑州大学第一附属医院消化内科 郑州 450052
Author(s):
YANG WanheLI JiaqunTONG YalinLI LinjingLI ZhiguoFENG Baisui
Department of Gastroenterology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
糖类抗原199纤维蛋白原梗阻性黄疸鉴别诊断
Keywords:
carbohydrate antigen 199fibrinogenobstructive jaundicedifferential diagnosis
分类号:
R575
摘要:
目的:评价血清糖类抗原199(CA199)和血浆纤维蛋白原(FIB)水平在良、恶性梗阻性黄疸鉴别诊断中的价值。方法:收集60例良性和75例恶性梗阻性黄疸患者,采用全自动免疫分析仪经电化学发光法检测血清CA199,采用全自动血栓/止血分析仪经光学法检测血浆FIB,绘制ROC曲线,确定诊断界值,计算特异度及灵敏度。结果:恶性梗阻性黄疸患者血清CA199及血浆FIB水平均高于良性梗阻性黄疸患者(Z=7.420,6.862,P<0.05)。ROC曲线分析结果显示:AUC(CA199)为0.872,95%可信区间(0.813~0.931);AUC(FIB)为0.844,95%可信区间(0.777~0.912)。取灵敏度+特异性的最高值所对应的截断点作为诊断界点,CA199的界点为35.085 U/mL,FIB为2.45 g/L,2者在选定界点的灵敏度(95%可信区间)分别为88.0%(82.5%~93.5%)和84.0%(77.8%~90.2%),联合检测灵敏度增加至98.7%(98.2%~99.2%)。结论:血清CA199与血浆FIB联合检测可提高良、恶性梗阻性黄疸鉴别诊断的灵敏度。
Abstract:
Aim: To explore the value of serum carbohydrate antigen 199(CA199) combined with plasma fibrinogen(FIB) for the differential diagnosis of benign and malignant obstructive jaundice. Methods:A total of 60 benign obstructive jaundice patients and 75 malignant obstructive jaundice patients were subjected to detect the serum CA199 and plasma FIB. The serum CA199 was detected via the electrochemical luminescence method.The plasma FIB was detected via the optics method. The diagnostic performance of CA199 and FIB in the benign and malignant obstructive jaundice was evaluated with ROC curve. Results: The levels of CA199 and FIB of the malignant obstructive jaundice patients were significantly higher than those of benign patients(Z=7.420,6.862,P<0.05). The AUC(CA199) and AUC(FIB) of ROC curve were 0.872 and 0.844,and 95%CI was (0.813-0.931) and (0.777-0.912).When the cutoff point was determined as 35.085 U/mL for CA199 and 2.45 g/L for FIB on the basis of highest value of sensitivity and specificity, the sensitivity(95%CI) of CA199, FIB, and combined detection were 88.0%(82.5%-93.5%),84.0%(77.8%-90.2%), and 98.7%(98.2%-99.2%). Conclusion: The combined detection of CA199 and FIB can improve the sensitivity of differential diagnosis of benign and malignant obstructive jaundice.

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更新日期/Last Update: 2013-09-01