[1]李艳,张菲斐#,邱春光,等.急性冠脉综合征患者血清卵泡抑素样蛋白1与病变严重程度的关系[J].郑州大学学报(医学版),2013,(05):678.
 LI Yan,ZHANG Feifei,QIU Chunguang,et al.Relationship between serum follistatinlike protein 1 level and severity of patients with acute coronary syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(05):678.
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急性冠脉综合征患者血清卵泡抑素样蛋白1与病变严重程度的关系
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年05期
页码:
678
栏目:
应用研究
出版日期:
2013-09-02

文章信息/Info

Title:
Relationship between serum follistatinlike protein 1 level and severity of patients with acute coronary syndrome
作者:
李艳张菲斐#邱春光韩战营黄振文
郑州大学第一附属医院心血管内科 郑州 450052
Author(s):
LI Yan ZHANG Feifei QIU Chunguang HAN ZhanyingHUANG Zhenwen
Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
卵泡抑素样蛋白1 急性冠脉综合征 生物标记物
Keywords:
follistatinlike protein 1acute coronary syndromebiomarker
分类号:
R541.4
摘要:
目的:探讨急性冠脉综合征(ACS)患者血清卵泡抑素样蛋白1(FSTL1)水平变化的意义。方法:ACS患者205例,依据ACC/AHA指南进行危险分层,分为低危组59例,中危组69例,高危组77例。选取同期非缺血性胸痛患者50例作对照。采用ELISA法测定血清FSTL1水平,采用Gensini评分系统评测冠脉病变严重程度,同时测定血脂、肌钙蛋白T(cTnT)和N末端B型利钠肽原(NTproBNP)等指标。结果:高危组、中危组、低危组及对照组4组间血清FSTL1水平差异有统计学意义(F=311.588,P<0.001),从高危组、中危组到低危组血清FSTL1水平逐渐降低(P<0.05),但均高于对照组(P<0.05)。高危组和中危组ACS患者血清FSTL1水平与Gensini评分、血清NTproBNP水平呈线性正相关(r=0.756、0.465和0.699、0.395, P均<0.01)。结论:血清FSTL1水平有可能成为评估早期ACS病变严重程度的生物标志物。
Abstract:
Aim: To explore the relationship between the serum level of follistatinlike protein 1(FSTL1) and the severity of coronary artery disease in patients with acute coronary syndrome(ACS). Methods:A total of 205 patients of ACS were divided into three groups according to ACC/AHA guide,the lowrisk group(n=59),the middlerisk group(n=69)and the highrisk group(n=77), and 50 individuals without ischemic chest pain were the control. The serum level of FSTL1 was examined by ELISA.The degree of coronary artery stenosis was assessed by Gensini score. The serum lipids,cardiac troponin T(cTnT) and Nterminal proBtype natriuretic peptide(NTproBNP) were detected. Results: There were significant differences in the serum level of FSTL1 among the 4 groups(F=311.588,P<0.001). Compared with the control group, the serum level of FSTL1 of ACS patients were higher, and decreased from the highrisk group, the middlerisk group to the lowrisk group(P<0.05). In the highrisk group, the correlation of the serum level of FSTL1 to Gensini score and serum NTproBNP level were positive(r=0.756 and 0.465, P<0.01),and the same with the middlerisk group(r=0.699 and 0.395, P<0.01).Conclusion:The serum level of FSTL1 may be a useful early biomarker for assessing severity degree of ACS.

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更新日期/Last Update: 2013-09-01