[1]俞悦),王震),穆永慧),等.自发性高血压大鼠学习记忆能力和脑组织SK2蛋白的表达*[J].郑州大学学报(医学版),2013,(06):746.
 YU Yue),WANG Zhen),MU Yonghui),et al.Expression of SK protein in brain tissue and the learning and memory capacity of spontaneously hypertensive rat[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(06):746.
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自发性高血压大鼠学习记忆能力和脑组织SK2蛋白的表达*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年06期
页码:
746
栏目:
论著
出版日期:
2013-11-20

文章信息/Info

Title:
Expression of SK protein in brain tissue and the learning and memory capacity of spontaneously hypertensive rat
作者:
俞悦1)王震1)穆永慧2)赵伟达3)韩丽娟1)张展1)章茜2)杨春2)#
1)郑州大学临床医学系 郑州 450052;2)郑州大学基础医学院生理学教研室 郑州 450001;3)河南大学生命科学院 开封 475004
Author(s):
YU Yue1)WANG Zhen1) MU Yonghui2)ZHAO Weida3)HAN Lijuan1) ZHANG Zhan1) ZHANG Qian2) YANG Chun2)
1)Division of Clinical Medicine, Zhengzhou University, Zhengzhou 450052; 2)Department of Physiology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001; 3)School of Life Science, Henan University, Kaifeng 475004
关键词:
自发性高血压 学习能力 记忆能力 小电导钙激活钾通道 大鼠
Keywords:
spontaneously hypertension learning capacity memory capacity small conductance Ca2+-activated K+ channel rat
分类号:
R338.64
摘要:
目的:探讨高血压对学习记忆能力的影响。方法:取自发性高血压(SH)大鼠和对照Wistar-Kyoto大鼠各7只,采用标准Ⅱ导联记录心电图,尾套法测定鼠尾动脉压,采用Y型迷宫和跳台实验测试大鼠的学习记忆能力,采用Western blot法检测脑组织小电导钙激活钾通道蛋白2(SK2)的表达。结果:与对照比较, SH大鼠鼠尾动脉压增高(t=12.060,P<0.001),QRS时长和R-R间期延长(t=3.147,3.917,P<0.05),Y型迷宫实验学习次数减少(t=3.279,P=0.007),跳台实验上台次数和上台受电击总时间增加(t=4.626,2.516,P<0.05);脑组织SK2蛋白表达也较对照组增加。结论:SK通道可能参与了高血压大鼠认知损害的过程。
Abstract:
Aim: To explore the influence of hypertension on learning and memory capacity. Methods:A total of 7 spontaneously hypertensive rats were used to detect arterial pressure with tail-trussed method, ECG was recorded using standard lead Ⅱ,and the learning and memory capacity was measured using Y-type electric maze and the jumping stand measurements, and Western blot was used to determine the expression of SK2 protein in brain tissue. Wistar-Kyoto rats were the control.Results: Compared with those of the control, arterial pressure of spontaneously hypertensive rats was higher(t=12.060,P<0.001), QRS duration and R-R interval prolonged(t=3.147,3.917,P<0.05),the learning times during Y-type electric maze measurements was less(t=3.279,P=0.007), the times of jumping onto the platform and the total time of shock increased(t=4.626,2.516,P<0.05), and the expression of SK2 protein in brain tissue was higher. Conclusion: SK channel may be associated with learning and memory damages of spontaneously hypertensive rats.

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金项目 81270248
#通讯作者,女,1975年2月生,硕士,副教授,研究方向:神经生理学,E-mail:yangchun@zzu.edu.cn
更新日期/Last Update: 2013-11-20