[1]田永,邹艳芳,徐峰#.大肠癌组织中Mina53和Mel-18蛋白的表达[J].郑州大学学报(医学版),2013,(06):780.
 TIAN Yong,ZOU Yanfang,XU Feng.Expressions of Mina53 and Mel-18 in colorectal carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(06):780.
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大肠癌组织中Mina53和Mel-18蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年06期
页码:
780
栏目:
应用研究
出版日期:
2013-11-20

文章信息/Info

Title:
Expressions of Mina53 and Mel-18 in colorectal carcinoma tissue
作者:
田永邹艳芳徐峰#
郑州大学第一附属医院消化内科 郑州 450052
Author(s):
TIAN Yong ZOU Yanfang XU Feng
Department of Gastroenterology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
大肠癌 Mina53 Mel-18
Keywords:
colorectal carcinoma Mina53 Mel-18
分类号:
R735.3
摘要:
目的:检测大肠癌组织中Mina53与Mel-18蛋白的表达。方法:采用免疫组化法分别检测60例大肠癌及相应癌旁正常大肠黏膜组织中Mina53与Mel-18蛋白的表达。结果:大肠癌及相应癌旁正常大肠黏膜组织中Mina53蛋白的阳性表达率分别为60.0%和0%,Mel-18蛋白的阳性表达率分别为31.7%和61.7%,2组间相比差异均有统计学意义(χ2=34.028、7.043, P均<0.05)。大肠癌组织中Mina53、Mel-18蛋白的表达与患者的性别、年龄无关(P均>0.05),而与肿瘤的浸润深度、淋巴结转移及分化程度有关(P均<0.05)。大肠癌组织中Mina53与Mel-18蛋白的表达呈负关联(rP=-0.557,P<0.001)。结论:Mina53与Mel-18的异常表达可能在大肠癌的发生发展中起重要作用。
Abstract:
Aim: To investigate the expressions of Mina53 and Mel-18 proteins in colorectal carcinoma tissue. Methods:The expressions of Mina53 and Mel-18 proteins were detected by immunohistochemistry in 60 colorectal carcinoma specimens and 60 normal colorectal mucosa specimens. Results: The positive expression rate of Mina53 in colorectal carcinoma and normal colorectal mucosa tissue was 60.0% and 0%,and that of Mel-18 was 31.7% and 61.7%, and there were significant differences(χ2=34.028,7.043, P<0.05). The expressions of Mina53 and Mel-18 proteins were associated with tumor infiltration depth, lymph node metastasis and tumor differentiation in colorectal carcinoma(P<0.05),but not with age or gender(P>0.05). A negative association was noted between the expression of Mina53 and that of Mel-18 in colorectal carcinoma tissue(rP=-0.557,P<0.001). Conclusion: The imbalance of Mina53 and Mel-18 expression may play an important role in the carcinogenesis and development of colorectal carcinoma.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1963年6月生,博士,教授,主任医师,研究方向:消化道肿瘤,E-mail:xufengmd@sina.com
更新日期/Last Update: 2013-11-20