[1]王淑娜,张轶乐,孙婧,等.冻融胚胎移植周期中子宫内膜容积、内膜及内膜下血流相关指数与妊娠结局的关系[J].郑州大学学报(医学版),2013,(06):821.
 WANG Shuna,ZHANG Yile,SUN Jing,et al.Relationship between endometrial volume,endometrial blood flow index,subendometrial blood flow index and clinical outcomes in frozen-thawed embryo transfer cycles[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(06):821.
点击复制

冻融胚胎移植周期中子宫内膜容积、内膜及内膜下血流相关指数与妊娠结局的关系
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年06期
页码:
821
栏目:
应用研究
出版日期:
2013-11-20

文章信息/Info

Title:
Relationship between endometrial volume,endometrial blood flow index,subendometrial blood flow index and clinical outcomes in frozen-thawed embryo transfer cycles
作者:
王淑娜张轶乐孙婧孙莹璞#
郑州大学第一附属医院生殖医学中心 郑州 450052
Author(s):
WANG Shuna ZHANG Yile SUN Jing SUN Yingpu
Reproductive Medical Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
三维超声 内膜容积 内膜及内膜下血流 冻融胚胎移植 妊娠结局
Keywords:
3D ultrasound endometrial volume endometrial and subendometrial blood flow frozen-thawed embryo transfer pregnancy outcome
分类号:
R711.6
摘要:
目的:探讨冻融胚胎移植周期中采用三维超声测量的子宫内膜厚度、容积、内膜及内膜下血流等指标与妊娠结局的关系。方法:选取2012年3月至5月于郑州大学第一附属医院生殖医学中心行冻融胚胎移植患者的226周期。采用三维超声测量胚胎移植日内膜厚度、容积、内膜及内膜下血流相关指数。按照妊娠结局分为妊娠组和未妊娠组、宫内妊娠组和异位妊娠组。结果:226周期中76周期获得临床妊娠,周期临床妊娠率33.6%, 3例异位妊娠,异位妊娠率3.9%。妊娠组与未妊娠组相比,子宫内膜血流指数(FI)[(22.199±5.961)vs(19.813±8.368)]差异有统计学意义(t=5.667,P=0.014);妊娠组内膜容积(4.181±1.899)mL大于未妊娠组的(3.678±1.557)mL(t=2.128,P=0.034);内膜容积<1.5 mL的患者共7例,均未获临床妊娠;2组间内膜厚度、其他内膜及内膜下血流相关指数比较,差异均无统计学意义(P均>0.05)。宫内妊娠组和异位妊娠组相比,内膜厚度、内膜容积、内膜及内膜下血流相关指数比较,差异均无统计学意义(P均>0.05)。结论:冻融胚胎移植周期中,三维超声测量的子宫内膜容积及内膜FI可预测妊娠结局;但三维超声测量指标不能预测妊娠部位。
Abstract:
Aim: To assess the value of indexes(endometrial thickness, endometrial volume, endometrial and subendometrial blood flow)measured by 3D ultrasound in predicting outcomes in women having transfer of cryopreserved embryos. Methods:A total of 226 cycles were included in this study.On the day of embryo transfer,endometrial thickness, endometrial volume, endometrial and subendometrial blood flow were measured under 3D ultrasound. The patients were grouped according to the pregnancy outcomes in order to analyze the relationships between each index and outcomes. Results: The cycle pregnancy rate was 33.6%(76/226).There were significant differences in endometrial flow index(FI)(t=5.667,P=0.014),endometrial volume(t=2.128,P=0.034)between pregnant [(22.199±5.961),(4.181±1.899)mL] and non-pregnant [(19.813±8.368),(3.678±1.557)mL] patients.Meanwhile, the differences of endometrial thickness, endometrial VI, VFI, and subendometrial FI, VI, VFI between the two groups were not significant(P>0.05). Furthermore,there were no significant differences in endometrial thickness, volume, endometrial VI, FI,VFI, or subendometrial VI,FI,VFI between intrauterine and ectopic pregnancy groups(P>0.05). Conclusion: Measurements of volume and endometrial FI by 3D ultrasound could forecast pregnancy outcomes.However, they could not forecast conception position.

参考文献/References:

[1] Nardo LG, Nikas G, Makrigiannakis A.Molecules in blastocyst implantation.Role of matrix metalloprot einases, cytokines and growth factors[J]. J Reprod Med,2003, 48(3):137
[2] 孙莹璞,苏迎春,郭艺红,等.体外受精-胚胎移植技术在常规超排卵304个治疗周期中的应用[J]. 郑州大学学报:医学版,2002,37(1):1
[3] 金海霞,孙莹璞,辛志敏,等.不同冷冻法对小鼠未成熟与成熟卵母细胞的成熟及胚胎发育的影响[J]. 中华妇产科杂志,2005,40(7):485
[4] Zegers-Hochschild F, Adamson GD, de Mouzon J, et al. International Committee for Monitoring Assisted Reproductive Technology(ICMART)and the World Health Organization(WHO)revised glossary of ART terminology, 2009[J]. Fertil Steril,2009,92(5):1520
[5] Ng EH, Chan CC, Tang OS, et al. The role of endometrial and subendometrial vascularity measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during frozen-thawed embryo transfer cycles[J].Human Reprod,2006,21(6):1612
[6] Wang L, Qiao J, Li R, et al. Role of endometrial blood flow assessment with color Doppler energy in predicting pregnancy outcome of IVF-ET cycles [J].Reprod Biol Endocrinol, 2010, 8:122
[7] Zhao J, Zhang Q, Li Y. The effect of endometrial thickness and pattern measured by ultrasonography on pregnancy outcomes during IVF-ET cycles [J]. Reprod Biol Endocrinol, 2012,10:100
[8] Zollner U, Specketer MT, Dietl J, et al.3D-Endometrial volume and outcome of cryopreserved embryo replacement cycles[J].Arch Gynecol Obstet, 2012,286(2):517
[9] Kovachev E, Ganchev ZH, Chemeva S, et al.Measurement of endometrial volume and endometrial thickness for assessment of endometrial receptivity in assisted reproductive techniques[J]. Akush Ginekol(Sofiia), 2005, 44(Suppl 2):27
[10]Park SS,Park MJ,Joo BS, et al.Improvement of ovarian response and oocyte quality of aged female by administration of bone morphogenetic protein-6 in a mouse model [J]. Reprod Biol Endocrinol,2012,10:117
[11]Boudjenah R, Molina-Gomes D, Wainer R, et al.The vascular endothelial growth factor(VEGF)+405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI[J]. Assist Reprod Genet, 2012, 29(12):1415
[12]Ng EH, Chan CC, Tang OS, et al. Endometrial and subendometrial vascularity is higher in pregnant patients with livebirth following ART than in those who suffer a miscarriage[J]. Hum Reprod, 2007, 22(4):1134
[13]Ng EH, Chan CC, Tang OS, et al. The role of endometrial and subendometrial blood flows measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during IVF treatment[J]. Hum Reprod, 2006, 21(1):164
[14]王丽娜,苏雪松,乔杰,等.子宫内膜内及子宫内膜内下血流对胚胎解冻周期妊娠结局的影响[J].中国微创外科杂志,2012,12(3):245

相似文献/References:

[1]栗河舟△,李洁,刘云,等.三维超声在胎儿肢体畸形诊断中的应用*[J].郑州大学学报(医学版),2012,(04):515.
 LI Hezhou,LI Jie,LIU Yun,et al.Application of threedimensional ultrasound in fetal limb deformities diagnosis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(06):515.

备注/Memo

备注/Memo:
#通讯作者,女,1962年1月生,博士,主任医师,教授,研究方向:生殖医学,E-mail:syp2008@vip.sina.com
更新日期/Last Update: 2013-11-20