[1]郭素萍),张霞),高传玉)#.大剂量瑞舒伐他汀对急性心肌梗死患者血清高敏C反应蛋白、MMP-9及心功能的影响[J].郑州大学学报(医学版),2013,(06):836.
 GUO Suping),ZHANG Xia),GAO Chuanyu).Effect of large dose rosuvastatin on hs-CRP, MMP-9 and cardiac function in patients with acute myocardial infarction[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(06):836.
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大剂量瑞舒伐他汀对急性心肌梗死患者血清高敏C反应蛋白、MMP-9及心功能的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2013年06期
页码:
836
栏目:
应用研究
出版日期:
2013-11-20

文章信息/Info

Title:
Effect of large dose rosuvastatin on hs-CRP, MMP-9 and cardiac function in patients with acute myocardial infarction
作者:
郭素萍1)张霞2)高传玉1)#
1)郑州大学人民医院心内科监护病房 郑州 450003;2)河南中医学院第一附属医院重症医学科 郑州 450008
Author(s):
GUO Suping1)ZHANG Xia2)GAO Chuanyu1)
1)Department of Cardiology Intensive Care Unit, Peoples Hospital, Zhengzhou University, Zhengzhou 450003; 2)Department of Intensive Care Unit, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou 450008
关键词:
瑞舒伐他汀 急性心肌梗死 高敏C反应蛋白 基质金属蛋白酶-9 心功能
Keywords:
rosuvastatin acute myocardial infarction high-sensitivity C-reactive protein MMP-9 cardiac function
分类号:
R743.3
摘要:
目的:观察大剂量瑞舒伐他汀对急性心肌梗死(AMI)患者血清高敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)及心功能的影响。方法:70例AMI患者分为瑞舒伐他汀(10 mg/d)常规剂量治疗组和瑞舒伐他汀(20 mg/d)大剂量治疗组,每组35例。2组均在治疗24 h、12周抽取患者静脉血,ELISA法检测血清hs-CRP、MMP-9水平;应用超声心动图分别于治疗24 h、20周测量患者左室收缩末内径(LVESD)、左室舒张末内径(LVEDD)、左室射血分数(LVEF)、左室短轴缩短分数(FS)、心室舒张早期左房室瓣血流峰值流速/心室舒张晚期左房室瓣血流峰值流速(VE/VA)。结果:2组患者治疗24 h和12周血清hs-CRP、MMP-9水平差值,治疗24 h和20周LVESD、LVEDD、LVEF、FS、VE/VA差值的比较差异均有统计学意义(t=6.578、12.595、4.813、6.339、6.313、15.148和6.472,P均<0.05)。结论:大剂量瑞舒伐他汀可有效抑制AMI患者的心室重构,改善心脏功能,其效应较常规剂量增强。
Abstract:
Aim: To investigate the effect of large dose of rosuvastatin on the levels of serum high-sensitivity C-reactive protein(hs-CRP),matrix metallo-proteinase 9(MMP-9)and cardiac function in patients with acute myocardial infarction(AMI). Methods:Seventy patients with AMI were allocated into conventional-dose rosuvastatin(10 mg/d)group(control group)and large-dose rosuvastatin group(20 mg/d)at random. The serum levels of MMP-9 and hs-CRP were measured within 24 hours and 12 weeks after treatment, respectively. LVEDD,LVESD, LVEF,FS,and VE/VA were measured within 24 hours and 20 weeks after treatment using transthoracic Doppler echocardiography, respectively. Results: Compared with the control group,the changes of the serum levels of hs-CRP and MMP-9 and those of LVESD,LVEDD,LVEF,FS,VE/VA between the 2 time points in the large-dose rosuvastatin group was significantly different(t=6.578,12.595,4.813,6.339,6.313,15.148 and 6.472,P<0.05). Conclusion: Large dose rosuvastatin could inhibit ventricular remodeling,improve cardiac function and long-term prognosis of AMI patients.

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备注/Memo

备注/Memo:
#通讯作者,男,1962年8月生,博士,主任医师,研究方向:冠心病,E-mail:gaocy2000@yahoo.com.cn
更新日期/Last Update: 2013-11-20