[1]丰贵文),王志刚),李金锋),等.西罗莫司转换治疗对肾移植受者血脂的影响及辛伐他汀的降脂效果*[J].郑州大学学报(医学版),2014,(01):69.
 FENG Guiwen#,WANG Zhigang#,LI Jinfeng#,et al.Effects of sirolimus on blood lipids of renal transplant recipients and therapeutic effects of simvastatin[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(01):69.
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西罗莫司转换治疗对肾移植受者血脂的影响及辛伐他汀的降脂效果*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年01期
页码:
69
栏目:
应用研究
出版日期:
2014-01-20

文章信息/Info

Title:
Effects of sirolimus on blood lipids of renal transplant recipients and therapeutic effects of simvastatin
作者:
丰贵文1)王志刚1)李金锋1)庞新路1)崔芝利2)刘磊1)谢洪昌1)丰永花1)郭战3)尚文俊1)#
1)郑州大学第一附属医院肾移植科 郑州 4500522)郑州大学第三附属医院儿科 郑州 4500523)郑州大学第一附属医院泌尿外科 郑州 450052
Author(s):
FENG Guiwen1)#WANG Zhigang1)# LI Jinfeng1)#PANG Xinlu1)#CUI Zhili2)#LIU Lei1)#XIE Hongchang1)#FENG Yonghua1)#GUO Zhan3)# SHANG Wenjun1)#
1)Department of Kidney Transplantation, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 4500522)Department of Pediatrics, the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 4500523)Department of Urology, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
西罗莫司肾移植高脂血症辛伐他汀
Keywords:
sirolimus kidney transplant hyperlipidemia simvastatin
分类号:
R692.9
摘要:
目的:探讨西罗莫司转换治疗对肾移植受者血脂的影响以及辛伐他汀的降脂效果。方法:对106例使用西罗莫司替代钙调磷酸酶抑制剂转换治疗的肾移植受者随访1 a,观察高脂血症发生率。符合转换后高脂血症治疗标准的患者48例,给予辛伐他汀10 mg/d,晚间顿服;监测辛伐他汀治疗4周、8周后各项血脂指标、肝肾功能和不良反应发生情况。结果:106例中2例因出现大量蛋白尿而提前退组。1 a内高脂血症的发生率为46.2%(48/104)。与治疗前相比,辛伐他汀治疗4周、8周TC、TG、LDLC下降,HDLC升高(P<0.05);辛伐他汀治疗8周降脂效果优于4周(P<0.05),未见严重不良反应。结论:西罗莫司可致肾移植受者高脂血症;合用辛伐他汀降脂治疗安全性好,疗效确切、显著。
Abstract:
Aim: To investigate the effects of sirolimus substitution of calcineurin inhibitors on blood lipids of renal transplant recipients and clinical efficacy and safety of simvastatin. Methods: A total of 106 renal transplant recipients were given sirolimus and followed up for 1 year. The patients developed hyperlipidemia were recorded and treated with simvastatin at 10 mg/d. The lipids, liver and kidney function, and adverse reactions at 4 weeks and 8 weeks after the treatment were observed. Results: Two cases retired the study due to massive proteinuria. The incidence of hyperlipidemia was 46.2%(48/104). Compared with before, the serum TC,TG,and LDLC decreased while serum HDLC increased after 4 weeks and 8 weeks treatment of simvastatin without serious adverse events(P<0.05); the lipidlowering efficacy of 8 weeks treatment was better than that of 4 weeks.Conclusion: Sirolimus leads to hyperlipidemia in renal transplant recipients; simvastatin combination could downregulate serum lipids efficiently and safely.

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目U1204820;郑州大学第一附属医院青年基金资助项目2011QN010;#通讯作者,男,1979年11月生,博士,副教授,副主任医师,研究方向:肾脏移植与免疫耐受,Email:shangwj111@163.com
更新日期/Last Update: 2014-02-20