[1]李明,法宪恩#,杨景学,等.急性主动脉夹层患者血浆细胞因子及内毒素水平测定*[J].郑州大学学报(医学版),2014,(01):80.
 LI Ming,FA Xianen,YANG Jingxue,et al.Detection of cytokines and endotoxin in plasma of patients with acute aortic dissection[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(01):80.
点击复制

急性主动脉夹层患者血浆细胞因子及内毒素水平测定*
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年01期
页码:
80
栏目:
应用研究
出版日期:
2014-01-20

文章信息/Info

Title:
Detection of cytokines and endotoxin in plasma of patients with acute aortic dissection
作者:
李明法宪恩#杨景学赵根尚王宏山黄真锋
郑州大学第二附属医院心血管外科 郑州 450014
Author(s):
LI Ming FA Xianen YANG Jingxue ZHAO Genshang WANG Hongshan HUANG Zhenfeng
Department of Cardiovascular Surgery, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
关键词:
急性主动脉夹层全身炎性反应综合征细胞因子内毒素
Keywords:
acute aortic dissection systemic inflammatory response syndrome cytokine endotoxin
分类号:
R654.3
摘要:
目的:探讨急性主动脉夹层患者血浆细胞因子及内毒素水平的变化及其与疾病预后的关系。方法:选取郑州大学第二附属医院心血管外科2005年1月至2012年12月收治的急性主动脉夹层患者85例,入院后均行急诊手术治疗。根据预后分为死亡组(16例)和生存组(69例)。分别于入院时(T1)、入院后12 h(T2)、入院后24 h(T3)取患者血液分离血浆,测定血浆中IL6、IL10、TNFα及内毒素水平。结果:与生存组比较,死亡组IL6、TNFα、内毒素水平在各时间点均增高(F组间=3.914、5.973、9.156,P均<0.05);生存组与死亡组内各时间点IL6、TNFα、内毒素水平比较,差异均有统计学意义(F时间=5.135、11.548、8.875,P均<0.05),且与T1比较,生存组T3的IL6、TNFα水平,死亡组T2的IL6水平,死亡组T3的IL6、TNFα、内毒素水平均升高(P均<0.05)。2组间IL10水平比较及组内各时间点间比较,差异均无统计学意义(F组间=1.674,F时间=2.901,P均>0.05)。结论:急性主动脉夹层病情进展迅速, IL6、TNFα及内毒素水平的急剧增加可能提示患者预后不佳。
Abstract:
Aim: To identify the relationship between cytokines and endotoxin changes of patients with acute aortic dissection and prognosis. Methods: A total of 85 patients with acute aortic dissection from Department of Cardiovascular Surgery of the Second Affiliated Hospital of Zhengzhou University from January 2005 to December 2012 were divided into death group and survival group according to prognosis. At the time of admission(T1), 12 hours after admission(T2), 24 hours after admission(T3), IL6, IL10, TNFα and endotoxin levels in plasma were measured. Results: Compared with the survival group, the levels of IL6, TNFα and endotoxin in the death group at each time point were significantly higher(Fgroup=3.914,5.973,9.156,P<0.05). There were significant differences of IL6,TNFα and endotoxin levels among three time points in two groups (Ftime=5.135,11.548,8.875,P<0.05). And compared with T1, IL6 and TNFα levels in the survival group at T3, IL6 level in the death group at T2, IL6, TNFα and endotoxin levels in the death group at T3 were significantly higher (P<0.05). There was no significant difference in IL10 level between two groups and among three time points (Fgroup=1.674,Ftime=2.901, P>0.05).Conclusion: Acute aortic dissection progresses rapidly, and dramatic increase of IL6, TNFα and endotoxin may indicate poor prognosis.

参考文献/References:

[1]Li M, Luo N, Bai Z, et al.A canine model of multiple organ dysfunction following acute typeA aortic dissection[J].Surg Today, 2012, 42(9):876 [2]Emura I, Usuda H. Histopathological and cytological examination of autopsy cases with multiple organ dysfunction syndromes[J].Pathol Int,2010, 60(6):443 [3]Cuschieri J, Bulger E, Schaeffer V,et al. Early elevation in random plasma IL6 after severe injure is associated with development of organ failure[J]. Shock,2010, 34(4):346 [4]赵利华,李章伟,杨闯,等.毛冬青甲素对兔颈总动脉球囊损伤后炎性因子IL6和MCSF的影响[J].吉林大学学报:医学版,2008,34(1):105 [5]Deiteh EA,Xu D,Kaise VL. Role of the gut in the development of injury and shock induced SIRS and MODS:the gutlymph hypothesis,a review[J].Front Biosci,2006,11(11):520 [6]张振香,林蓓蕾,陈颖,等.外周穿刺中心静脉置管术患者炎症细胞因子和凝血四项水平分析[J].郑州大学学报:医学版,2011,46(6):849 [7]桑淼,陈颖,关海霞.亚急性甲状腺炎血浆纤维蛋白原变化及其临床意义[J].中国实用内科杂志,2012,32(10):800 [8]Grootjans J, Lenaerts K, Derikx JP,et al. Human intestinal ischemiareperfusioninduced inflammation characterized: experiences from a new translational model[J].Am J Pathol, 2010, 176(5):2283 [9]Wen D, Zhou XL,Li JJ,et al. Plasma concentrations of interleukin6, Creactive protein, tumor necrosis factoralpha and matrix metalloproteinase9 in aortic dissection[J]. Clin Chim Acta,2012, 413(1/2):198 [10]Nomura F, Tamura K,Yoshitatsu M,et al. Changes in coagulation condition, cytokine, adhesion molecule after repair of type A aortic dissection[J].Eur J Cardiothorac Surg,2004, 26(2):348 [11]马丽,张薇华,周光纪,等.白藜芦醇对小鼠胰岛样细胞团的抗移植排斥作用及其IL2、IL10表达的影响[J].解放军医学杂志,2012,37(6):606 [12]章琳,杨渭临.沙利度胺对老年特发性肺纤维化患者BALF中IL6、TNFα、TGFβ1表达的影响[J].西安交通大学学报:医学版,2012,33(5):622 [13]钱程,韦丹,李眉.不同液体复苏对脓毒性休克早期大鼠血清细胞因子变化的影响[J].中华实用儿科临床杂志,2013,28(6):414 [14]赵艳,张俊,彭星,等.抑肽酶和乌司他丁在体外循环中抗炎作用的比较[J].第三军医大学学报,2009,31(24):2490

备注/Memo

备注/Memo:
*河南省卫生科技创新人才工程项目20100120;河南省医学学术技术带头人出国培训计划项目201201053;#通讯作者,男,1962年8月生,博士,主任医师,研究方向:心血管外科,Email:faxianen@163.com
更新日期/Last Update: 2014-02-20