[1]胡文晖),郝斌)#,李惠翔),等.不同组织学类型膀胱癌组织中HER2蛋白的表达[J].郑州大学学报(医学版),2014,(01):96.
 HU Wenhui#,HAO Bin#,LI Huixiang#,et al.Expression of HER2 protein in different histological types of bladder cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(01):96.
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不同组织学类型膀胱癌组织中HER2蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年01期
页码:
96
栏目:
应用研究
出版日期:
2014-01-20

文章信息/Info

Title:
Expression of HER2 protein in different histological types of bladder cancer
作者:
胡文晖1)郝斌1)#李惠翔2)张志臣1)
1)郑州大学第二附属医院泌尿外科 郑州 4500142)郑州大学第一附属医院病理科 郑州 450052
Author(s):
HU Wenhui1)#HAO Bin1)#LI Huixiang2)#ZHANG Zhichen1)#
1)Department of Urology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 4500142)Department of Pathology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
膀胱肿瘤HER2蛋白
Keywords:
bladder neoplasmHER2 protein
分类号:
R737.14
摘要:
目的:探讨不同组织学类型膀胱癌组织中HER2蛋白的表达及意义。方法:采用免疫组化法检测73例不同组织学类型的膀胱癌组织中HER2蛋白的表达水平及其与临床分期、病理分级之间的关系。结果:HER2蛋白在膀胱鳞状细胞癌(鳞癌)、腺癌和尿路上皮细胞癌组织的阳性表达率分别为88.9%(16/18)、88.2%(15/17)和57.9%(22/38),差异有统计学意义(P=0.016),鳞癌和腺癌两者之间的表达差异无统计学意义(P>0.999),尿路上皮细胞癌组织中HER2的阳性表达率低于鳞癌和腺癌 (χ2=8.620,P=0.003);膀胱癌组织中HER2蛋白的表达与患者的性别、年龄、肿瘤大小无关(P>0.05),而与肿瘤TNM分期、分化程度及淋巴结转移有关(χ2=7.980,11.559,11.934,P<0.05)。结论:HER2蛋白可以作为鉴别不同组织学类型膀胱癌的潜在指标,并与膀胱癌的增殖、浸润、转移密切相关。
Abstract:
Aim: To explore the expression and the significance of HER2 protein in different histological types of bladder cancers.Methods: The immunohistochemistry SP method was used to detect the expression of HER2 protein in 73 cases of different histological types of bladder cancers.Results: The positive expression rate of HER2 protein was 88.9%(16/18) in squamous cell cancer,88.2%(15/17) in adenocarcinoma and 57.9%(22/38) in urothelial cell carcinoma, there were statistical differences(P=0.016), there was no significant difference between squamous cell carcinoma and adenocarcinoma (P>0.999). The positive expression rate of HER2 in urothelial cell carcinoma were lower than those in squamous cell carcinoma and adenocarcinoma (χ2=8.620,P=0.003).The expression of HER2 protein in bladder cancer was not correlated with patients gender, age or tumor size(P>0.05),but correlated with the tumor TNM stage,differentiation degree and lymph node metastasis (χ2=7.980,11.559,11.934,P<0.05).Conclusion: HER2 protein can be used as potential indicators identifing different histological types of bladder cancer and closely related with bladder cancers proliferation, invasion and metastasis.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1956年11月生,博士,教授,主任医师,研究方向:泌尿外科疾病基础与临床,Email:binhao68@hotmail.com
更新日期/Last Update: 2014-02-20