[1]谢爱民△,胡建明,陈艰,等.肺癌组织中SOX2和βcatenin蛋白的表达[J].郑州大学学报(医学版),2014,(01):105.
 XIE Aimin,HU Jianming,CHEN Jian,et al.Expressions of SOX2 and βcatenin protein in lung cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(01):105.
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肺癌组织中SOX2和βcatenin蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年01期
页码:
105
栏目:
应用研究
出版日期:
2014-01-20

文章信息/Info

Title:
Expressions of SOX2 and βcatenin protein in lung cancer tissue
作者:
谢爱民胡建明陈艰孙黄涛林庆陈美芳陈梅花
江西省人民医院心胸外科 南昌 330000
Author(s):
XIE AiminHU JianmingCHEN JianSUN HuangtaoLIN QingCHEN MeifangCHEN Meihua
Department of Cardiothoracic Surgery, Jiangxi Provincial People’s Hospital,Nanchang 330000
关键词:
肺癌肿瘤干细胞SOX2Wnt/βcatenin信号通路
Keywords:
lung cancer tumor stem cell SOX2 Wnt/βcatenin pathway
分类号:
R734.1
摘要:
目的:探讨SOX2及Wnt/βcatenin信号通路与肺癌发生的关系。方法:收集86例肺癌组织和20例正常肺组织标本,应用免疫组化法检测SOX2、βcatenin蛋白的表达,分析SOX2、βcatenin蛋白在肺癌组织中表达的关联性。结果:SOX2在肺癌组织中的阳性表达率为95.4%,在正常肺组织中无表达;βcatenin在肺癌组织中的阳性表达率为 75.6%,在正常肺组织中为30.0%;肺癌组织中两种蛋白的阳性表达率均高于正常肺组织(P<0.001)。二者在肺癌组织中的表达无关联(rP=0.109,P=0.978)。结论:SOX2和Wnt/βcatenin信号通路在肺癌的发生过程中发挥了重要作用。
Abstract:
Aim: To investigate the expressions of stem cell factors SOX2 and βcatenin in lung cancer tissue. Methods:A total of 86 cases of lung cancer tissue and 20 cases of normal lung tissue were collected and used to detect the expressions of SOX2 and βcatenin by immunohistochemistry analysis. The correlation between SOX2 and βcatenin expressions in lung cancer tissue was analyzed. Results: The positive expression rates of SOX2 and βcatenin were 95.4% and 75.6% in lung cancer tissue, significantly higher than those(0.0% and 30.0%) in normal lung tissue(P<0.001). There was no positive correlation between SOX2 and βcatenin expressions in lung cancer tissue(rP=0.109,P=0.978). Conclusion: SOX2 and Wnt/βcatenin pathway may play important roles in occurrence of lung cancer.

参考文献/References:

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备注/Memo

备注/Memo:
△男,1970年12月生,硕士,副主任医师,研究方向:心胸外科临床,Email:xieaimin1998@126.com
更新日期/Last Update: 2014-02-20