[1]封全灵△,刘弘扬.子宫平滑肌瘤组织中孕激素受体和porin mRNA的表达[J].郑州大学学报(医学版),2014,(01):116.
 FENG Quanling,LIU Hongyang.Expressions of 3 isoforms of human progesterone receptors and porin mRNA in uterine leiomyoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(01):116.
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子宫平滑肌瘤组织中孕激素受体和porin mRNA的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年01期
页码:
116
栏目:
应用研究
出版日期:
2014-01-20

文章信息/Info

Title:
Expressions of 3 isoforms of human progesterone receptors and porin mRNA in uterine leiomyoma tissue
作者:
封全灵刘弘扬
郑州大学第三附属医院妇产科 郑州 450052
Author(s):
FENG QuanlingLIU Hongyang
Department of Gynecology and Obstetrics, the Third Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
孕激素受体子宫平滑肌瘤porin
Keywords:
progesterone receptoruterine leiomyomaporin
分类号:
R711.74
摘要:
目的:探讨孕激素促进子宫平滑肌瘤形成的机制。方法:采用RTPCR方法检测28例子宫平滑肌瘤组织(研究组)和瘤旁正常子宫平滑肌组织(对照组)中新型孕激素受体(PR)M、PRA、PRB和线粒体porin mRNA的表达。结果:研究组PRM、porin、PRA和PRB mRNA的表达均高于对照组(t=23.935、12.881、10.059和9.332,P<0.001);研究组中PRM和porin mRNA的表达呈正相关(r=0.431,P=0.022)。结论:PRM可能通过非基因组途径参与子宫平滑肌瘤的形成。
Abstract:
Aim: To explore the mechanism of progesterone acts on genesis of uterine leiomyoma.Methods: RTPCR was used to detect the mRNA expressions of progesterone receptor(PR)M,PRA,PRB and porin in 28 cases of uterine leiomyoma(leiomyoma group,LG) and their corresponding myometrium(control group,CG).Results: The mRNA levels of PRM, porin, PRA and PRB were higher in LG compared with those in CG(t=23.935,12.811,10.059 and 9.332,P<0.001).Pearson correlation analysis showed that there was positive correlation between PRM and porin mRNA in LG(r=0.431,P=0.022).Conclusion: PPM may act through genomic and nongenomic actions in the genesis and growth of uterine leiomyoma.

参考文献/References:

[1]Gellersen B, Fernandes MS, Brosens JJ. Nongenomic progesterone actions in female reproduction[J].Hum Reprod Update, 2009,15(1):119 [2]Dai Q, Shah AA, Garde RV, et al. A Truncated progesterone receptor(PRM) localizes to the mitochondrion and controls cellular respiration[J]. Mol Endocrinol, 2013,27(5):741 [3]封全灵.PRM对子宫平滑肌细胞线粒体膜电位作用的研究[D].郑州:郑州大学,2010. [4]Behera MA, Dai Q, Garde R, et al. Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF10A benign breast epithelial cells[J]. Am J Physiol Endocrinol Metab, 2009,297(5):E1089 [5]Saner KJ, Welter BH, Zhang F, et al.Cloning and expression of a novel, truncated, progesterone receptor[J].Mol Cell Endocrinol, 2003,200(1/2):155 [6]ShoshanBarmatz V, Israelson A, Brdiczka D, et al. The voltagedependent anion channel (VDAC): function in intracellular signalling, cell life and cell death[J]. Curr Pharm Des, 2006, 12(18): 2249 [7]Young MJ, Bay DC, Hausner G, et al. The evolutionary history of mitochondrial porins[J]. BMC Evol Biol, 2007,7:31 [8]Viville B, CharnockJones DS , Sharkey AM , et al . Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium[J]. Human Reprod, 1997, 12(4): 815 [9]ShoshanBarmatz V, De Pinto V, Zweckstetter M,et al.VDAC,a multifunctional mitochondrial protein regulating cell life and death[J].Mol Aspects Med, 2010,31(3):227 [10]Rapizzi E, Pinton P, Szabadkai G, et al.Recombinant expression of the voltagedependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria[J]. J Cell Biol, 2002, 159(4): 613 [11]Faivre EJ, Lange CA.Progesterone receptors upregulate Wnt1 to induce epidermal growth factor receptor transactivation and cSrcdependent sustained activation of Erk1/2 mitogenactivated protein kinase in breast cancer cells[J]. Mol Cell Biol,2007,27(2):466

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备注/Memo

备注/Memo:
△女,1965年4月生,博士,主任医师,研究方向:妇科肿瘤,Email:zzufql@126.com
更新日期/Last Update: 2014-02-20