[1]周文娟,孟跃进#,郭晓峰,等.宫颈癌组织中ZEB2和Ecad蛋白的表达[J].郑州大学学报(医学版),2014,(02):219.
 ZHOU Wenjuan,MENG Yuejin,GUO Xiaofeng,et al.Expressions of ZEB2 and Ecad proteins in cervical cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(02):219.
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宫颈癌组织中ZEB2和Ecad蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年02期
页码:
219
栏目:
应用研究
出版日期:
2014-03-20

文章信息/Info

Title:
Expressions of ZEB2 and Ecad proteins in cervical cancer tissue
作者:
周文娟孟跃进#郭晓峰闫东
郑州大学第二附属医院妇产科 郑州 450014
Author(s):
ZHOU WenjuanMENG YuejinGUO XiaofengYAN Dong
Department of Gynecology and Obstetrics, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
关键词:
宫颈癌E盒结合锌指蛋白2E钙黏附蛋白预后
Keywords:
cervical cancer ZEB2 Ecad prognosis
分类号:
A
文献标志码:
R737.33
摘要:
目的:探讨E盒结合锌指蛋白2(ZEB2)和E钙黏附蛋白(Ecad)在宫颈癌组织中的表达情况及与预后的关系。方法:用免疫组化SP法检测144例宫颈癌和26例正常宫颈黏膜组织中ZEB2和Ecad蛋白的表达,并对随访资料进行预后分析。结果:宫颈癌和正常宫颈黏膜组织中ZEB2蛋白的阳性表达率分别为83.3%(120/144)和11.5%(3/26)(χ2=56.750,P<0.001);Ecad蛋白的阳性表达率分别为29.2%(42/144)和100.0%(26/26)(P<0.001)。ZEB2、Ecad蛋白表达与宫颈癌的分化程度、FIGO分期及淋巴结转移均有关(P均<0.05)。宫颈癌组织中ZEB2与Ecad蛋白表达有关联(rp=0.411,P<0.001)。FIGO分期(RR=1.788,95%CI 1.239~2.580)、淋巴结转移(RR=1.702,95%CI 1.181~2.453)、Ecad表达(RR=0.572,95%CI 0.369~0.888)及ZEB2表达(RR=1.810,95%CI 1.046~3.131)可作为宫颈癌预后的独立因素。结论:ZEB2和Ecad可能会促进宫颈癌的发展、浸润和转移,可作为预测宫颈癌预后的新指标。
Abstract:
Aim: To explore the relationship between the prognosis and the expressions of ZEB2 and Ecad proteins in cervical cancer tissue. Methods: The expressions of ZEB2 and Ecad proteins in 144 cases of cervical cancer tissue and 26 cases of normal tissue were detected by immunohistochemical SP technique. Results: The ZEB2 positive expression rate in the cervical cancer tissue and normal tissue was 83.3%(120/144) and 11.5%(3/26)(χ2=56.750,P<0.001). The Ecad positive expression rate in the cervical cancer tissue and normal tissue was 29.2%(42/144) and 100.0%(26/26)(P<0.001). The positive expressions of ZEB2 and Ecad were related with differentiation,FIGO stage and lymph node metastasis(P<0.05). The expressions of ZEB2 and Ecad were related in cervical cancer tissue(rp=0.411,P<0.001). FIGO stage(RR=1.788,95%CI 1.239-2.580), lymph node metastasis(RR=1.702,95%CI 1.181-2.453), Ecad expression(RR=0.572,95%CI 0.369-0.888) and ZEB2 expression(RR=1.810,95%CI 1.046-3.131) in the cervical cancer tissue were independent prognostic factors. Conclusion: ZEB2 and Ecad may promote the development, invasion and metastasis of cervical cancer, which may be the new indicators to predict the prognosis of cervical cancer.

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备注/Memo

备注/Memo:
#通讯作者,男,1958年3月生,本科,教授,研究方向:宫腔镜在妇科良、恶性疾病中的应用,Email:myj6699@163.com
更新日期/Last Update: 2014-04-23