[1]赵红宇),张淼),岳新新),等.侵袭性牙周炎患者牙龈组织中MMP1、MMP8和MMP13蛋白的表达*[J].郑州大学学报(医学版),2014,(02):227.
 ZHAO Hongyu,ZHANG Miao,YUE Xinxin,et al.Expressions of MMP1,MMP8 and MMP13 in gingival tissue of patients with aggressive periodontitis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(02):227.
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侵袭性牙周炎患者牙龈组织中MMP1、MMP8和MMP13蛋白的表达*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年02期
页码:
227
栏目:
应用研究
出版日期:
2014-03-20

文章信息/Info

Title:
Expressions of MMP1,MMP8 and MMP13 in gingival tissue of patients with aggressive periodontitis
作者:
赵红宇12)张淼3)岳新新4)轩东英4)刘林嶓1)#周磊5)#
1)郑州大学第一附属医院整形外科 郑州 450052 2)南方医科大学附属口腔医院;广东省口腔医院番禺分院牙周科 广州 511400 3)郑州大学口腔医学院 郑州 450052 4)南方医科大学附属口腔医院;广东省口腔医院牙周科 广州 510280 5)南方医科大学附属口腔医院;广东省口腔医院种植中心 广州 510280
Author(s):
ZHAO Hongyu12)ZHANG Miao3) YUE Xinxin4) XUAN Dongying4)LIU Linbo1)ZHOU Lei4)
1)Department of Plastic Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Periodontology, Panyu Branch,Guangdong Provincial Stomatological Hospital; the Affiliated Stomatological Hospital of Southern Medical University, Guangzhou 511400 3)School of Stomatology,Zhengzhou University, Zhengzhou 450052 4)Department of Periodontology, Guangdong Provincial Stomatological Hospital; the Affiliated Stomatological Hospital of Southern Medical University, Guangdong 510280 5)Implant Center,Guangdong Provincial Stomatological Hospital; the Affiliated Stomatological Hospital of Southern Medical University, Guangdong 510280
关键词:
侵袭性牙周炎MMP1MMP8MMP13胶原酶
Keywords:
aggressive periodontitis MMP1 MMP8 MMP13 collagenase
分类号:
A
文献标志码:
R781.4
摘要:
目的:检测侵袭性牙周炎(AgP)患者牙龈组织中基质金属蛋白酶(MMP)1、MMP8及MMP13的表达,探讨三者在AgP发病中的可能作用和意义。方法:采用免疫组化法检测30例AgP患者和20例健康对照牙龈组织中MMP1、MMP8及MMP13蛋白的表达。结果:健康对照牙龈组织中MMP1、MMP8及MMP13均有弱表达;AgP患者牙龈组织中MMP1和MMP8蛋白的表达高于健康对照(Z=3.980和2.990,P<0.05)。结论:MMP1、MMP8蛋白可能在AgP的发生中起重要作用。
Abstract:
Aim: To analyze the roles of three collagenases(MMP1,MMP8 and MMP13) in the pathogenesis of aggressive periodontitis(AgP). Methods: The expressions of MMP1, MMP8 and MMP13 in gingival tissue of 30 patients with AgP and 35 healthy controls were detected by immunohistochemistry method. Results: Low expressions of MMP1, MMP8 and MMP13 were shown in healthy control group. Higher expressions of MMP1 and MMP8 were found in the AgP group compared with those of healthy control group(Z=3.980 and 2.990, P<0.05). Conclusion: MMP1 and MMP8 may play an important role in the development of AgP.

参考文献/References:

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相似文献/References:

[1]岳新新),薛蕊),张炜),等.侵袭性牙周炎患者牙龈组织中MMP8及TIMP1的表达*[J].郑州大学学报(医学版),2013,(03):366.
 YUE Xinxin),XUE Rui),ZHANG Wei),et al.Expressions of MMP8 and TIMP1 in gingival tissue of patients with aggressive periodontitis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(02):366.

备注/Memo

备注/Memo:
*广东省科技计划项目00204390134483040 #通讯作者,刘林嶓,1960年3月生,教授,主任医师,研究方向:整形外科、美容外科的临床医疗、教学和科研,Email:liulinbo@zzu.edu.cn;周磊,1956年11月生,教授,主任医师,研究方向:口腔颌面部肿瘤及口腔种植的临床研究,Email:zho668@263.net
更新日期/Last Update: 2014-04-23