[1]单峤)△,王新军),王世勋),等.人脑胶质瘤组织中X连锁凋亡抑制蛋白的表达[J].郑州大学学报(医学版),2014,(02):243.
 SHAN Qiao,WANG Xinjun,WANG Shixun,et al.Expression of Xlinked inhibitor of apoptosis protein in human glioma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(02):243.
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人脑胶质瘤组织中X连锁凋亡抑制蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年02期
页码:
243
栏目:
应用研究
出版日期:
2014-03-20

文章信息/Info

Title:
Expression of Xlinked inhibitor of apoptosis protein in human glioma tissue
作者:
单峤1)△王新军1)王世勋2)李培栋1)吴建珩1)李晓辉3)
1)郑州大学第五附属医院神经外科 郑州 450052 2)项城市第一人民医院神经外科 项城 466200 3)郑州大学附属洛阳中心医院神经外科 洛阳 471000
Author(s):
SHAN Qiao1)WANG Xinjun1)WANG Shixun2)LI Peidong1)WU Jianheng1) LI Xiaohui3)
1)Department of Neurosurgery, the Fifth Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Neurosurgery, the First Peoples Hospital of Xiangcheng,Xiangcheng 466200 3)Department of Neurosurgery,the Affiliated Luoyang Central Hospital, Zhengzhou University, Luoyang 471000
关键词:
X连锁凋亡抑制蛋白人脑胶质瘤半胱氨酸蛋白酶
Keywords:
Xlinked inhibitor of apoptosis proteinhuman gliomacaspase
分类号:
A
文献标志码:
R739.41
摘要:
目的:探讨X连锁凋亡抑制蛋白(XIAP)在人脑胶质瘤中的表达情况。 方法:收集低级别胶质瘤31例、高级别胶质瘤36例、 正常脑组织35例,分别采用RTPCR、Western blot和免疫组织化学染色方法测定脑组织中XIAP mRNA及蛋白表达水平。结果:低、高级别胶质瘤组织中XIAP mRNA及蛋白表达水平较正常脑组织显著上调,高级别胶质瘤组织中XIAP mRNA及蛋白表达水平较低级别胶质瘤组织显著上调(F=118.659和127.312,P<0.001)。结论:XIAP在人脑胶质瘤中呈高表达,且与胶质瘤的病理分级有关,可能参与人脑胶质瘤的发生和进展。
Abstract:
Aim: To investigate the expression and significance of Xlinked inhibitor of apoptosis protein(XIAP) in human glioma. Methods: There were 31 cases of low grade glioma,36 cases of high grade glioma and 35 cases normal brain tissue.The expressions of XIAP mRNA and protein were detected by RTPCR,Western blot and immunohistochemistry. Results: The expression levels of XIAP mRNA and protein were significantly higher in human glioma tissue than those in normal brain tissue,and the expression levels of XIAP mRNA and protein were significantly higher in highgrade glioma group than those in lowgrade glioma group(F=118.659 and 127.312,P<0.001). Conclusion: The mRNA and protein expression levels of XIAP were significantly high in human glioma which are associated with the grade of glioma.Therefore, XIAP may participate in the development and progression of human glioma.

参考文献/References:

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备注/Memo

备注/Memo:
△男,1969年8月生,博士,副主任医师,研究方向:胶质瘤的基础与临床;Email:shan_qiao@163.com
更新日期/Last Update: 2014-04-23