[1]姚俊阁,李红雨#,赵书君,等.卵巢上皮性癌组织中SOX2和CyclinD1的表达[J].郑州大学学报(医学版),2014,(02):247.
 YAO Junge,LI Hongyu,ZHAO Shujun,et al.Expressions of SOX2 and CyclinD1 in epithelial ovarian cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(02):247.
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卵巢上皮性癌组织中SOX2和CyclinD1的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年02期
页码:
247
栏目:
应用研究
出版日期:
2014-03-20

文章信息/Info

Title:
Expressions of SOX2 and CyclinD1 in epithelial ovarian cancer tissue
作者:
姚俊阁李红雨#赵书君张慧张艳艳郭欢欢
郑州大学第三附属医院妇产科 郑州 450052
Author(s):
YAO Junge LI Hongyu ZHAO Shujun ZHANG Hui ZHANG Yanyan GUO Huanhuan
Department of Gynecology and Obstetrics, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
SOX2CyclinD1卵巢上皮性癌
Keywords:
SOX2 CyclinD1 epithelial ovarian cancer
分类号:
A
文献标志码:
R737.31
摘要:
目的:检测卵巢上皮性癌组织中SOX2和CyclinD1的表达。方法:分别采用免疫组化SP法和RTPCR法检测20例正常卵巢上皮组织、20例卵巢良性上皮性肿瘤组织及43例卵巢上皮性癌组织中SOX2和CyclinD1蛋白及mRNA的表达。结果:3种组织间SOX2、CyclinD1蛋白及mRNA的表达差异有统计学意义(蛋白:χ2=32.998,mRNA:F=454.222、398.284,P均<0.05);卵巢上皮性癌组织中SOX2、CyclinD1蛋白及mRNA的表达高于卵巢良性上皮性肿瘤组织及正常卵巢上皮组织(P均<0.05)。SOX2、CyclinD1蛋白的表达均与卵巢上皮性癌FIGO分期、分化程度及淋巴结转移有关(P均<0.05)。卵巢上皮性癌组织中SOX2、CyclinD1蛋白的表达有关联(rp=0.422,P<0.05)。结论:SOX2和CyclinD1在卵巢上皮性癌组织中高表达,二者可能协同参与卵巢上皮性癌的发生及发展。
Abstract:
Aim: To explore the expressions and clinical significance of SOX2 and CyclinD1 in epithelial ovarian cancer tissue. Methods: Immunohistochemical SP method and RTPCR were used to separately detect the expressions of SOX2 and CyclinD1 in 20 cases of normal epithelial ovarian tissue, 20 cases of benign epithelial ovarian neoplasm tissue, and 43 cases of epithelial ovarian cancer tissue. Results: The expressions of SOX2 and CyclinD1 protein and mRNA in epithelial ovarian cancer tissue were significantly higher than those in benign epithelial ovarian neoplasm tissue and normal epithelial ovarian tissue(protein:χ2=32.998;mRNA:F=454.222,398.284, all P<0.05).The expressions of SOX2 and CyclinD1 protein in epithelial ovarian cancer tissue were related to FIGO stage, histological differentiation and lymph node metastasis(P<0.05).The expression of SOX2 protein was associated with that of CyclinD1 protein in epithelial ovarian cancer tissue(rp=0.422,P<0.05).Conclusion: SOX2 and CyclinD1 are both overexpressed in epithelial ovarian cancer tissue. SOX2 may be in coordinated with CyclinD1 in carcinogenesis and progression of epithelial ovarian cancer.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,女,1964年9月生,博士,教授,主任医师,研究方向:妇科肿瘤,Email:lihongyu99@qq.com
更新日期/Last Update: 2014-04-23