[1]孙荣青)△,朱丽超),周新阁),等.重组人促红细胞生成素对颅脑损伤患者血清脑红蛋白、血红蛋白含量的影响[J].郑州大学学报(医学版),2014,(02):257.
 SUN Rongqing,ZHU Lichao,ZHOU Xinge,et al.Influence of rhEPO on expressions of serum neuroglobin and hemoglobin in patients with craniocerebral injury[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(02):257.
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重组人促红细胞生成素对颅脑损伤患者血清脑红蛋白、血红蛋白含量的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年02期
页码:
257
栏目:
应用研究
出版日期:
2014-03-20

文章信息/Info

Title:
Influence of rhEPO on expressions of serum neuroglobin and hemoglobin in patients with craniocerebral injury
作者:
孙荣青1)△朱丽超1)周新阁2)杨宏富1)李菲菲1)史晓奕1)
1)郑州大学第一附属医院ICU 郑州 450052 2)遂平县第一人民医院神经外科 遂平 463100
Author(s):
SUN Rongqing1)ZHU Lichao1)ZHOU Xinge2)YANG Hongfu1)LI Feifei1)SHI Xiaoyi1)
1)Department of ICU, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Neurosurgery,the First People's Hospital of Suiping County, Suiping 463100
关键词:
重组人促红细胞生成素颅脑损伤脑红蛋白血红蛋白急性生理学及慢性健康状况评分系统Ⅱ评分
Keywords:
rhEPOcraniocerebral injuryneuroglobinhemoglobinAPACHE Ⅱ
分类号:
A
文献标志码:
R459.7
摘要:
目的:探讨重组人促红细胞生成素(rhEPO)对于颅脑损伤患者血清脑红蛋白(NGB)、血红蛋白(HGB)表达的影响。方法:选取50例重症监护病房颅脑损伤的患者,分为rhEPO组(30例)和对照组(20例)。rhEPO组患者在常规治疗的基础上于入院后第3、6、9、12天皮下注射rhEPO(100 00 IU/次);对照组患者仅给予常规治疗。监测所有患者入院时、入院第4、7、10和14天血清NGB、HGB含量及急性生理学及慢性健康状况评分系统Ⅱ(APACHE Ⅱ)评分的变化。结果:rhEPO组患者血清NGB含量(F组间=9.979,P=0.013;F时间=11.560,P<0.001;F交互=16.813,P<0.001)、HGB含量(F组间=23.260,P<0.001;F时间=22.340,P<0.001;F交互=6.903,P<0.001)较对照组增高,APACHE Ⅱ分值(F组间=9.339,P=0.016;F时间=13.749,P<0.001;F交互=5.497,P<0.001)较对照组下降。结论:rhEPO可促进颅脑损伤患者NGB、HGB的表达,降低APACHE Ⅱ 评分,具有一定的神经保护作用。
Abstract:
Aim: To explore the influence of rhEPO on expressions of serum neuroglobin and hemoglobin in patients with craniocerebral injury. Methods: Fifty cases of ICU patients with craniocerebral injury were randomly divided into rhEPO group(30 cases) and control group(20 cases).The rhEPO group was given rhEPO by subcutaneous injection at 10 000 IU each time besides conventional treatment when admitted to hospital, on the 3rd day, 6th day, 9th day,and 12th day.The control group was just given conventional treatment. The neuroglobin, hemoglobin, APACHE Ⅱ score of all the patients were monitored when admitted to hospital, on the 4th day, 7th day, 10th day, 14th day. Results: The neuroglobin in the rhEPO group was higher than the control group(Fgroup=9.979,P=0.013;Ftime=11.560,P<0.001;Finteraction=16.813,P<0.001);the hemoglobin in rhEPO group was higher than that in the control group(Fgroup=23.260,P<0.001;Ftime=22.340,P<0.001;Finteraction=6.903,P<0.001);the APACHE Ⅱ score in rhEPO group was lower than that in the control group(Fgroup=9.339,P=0.016;Ftime=13.749,P<0.001;Finteraction=5.497,P<0.001).Conclusion: Using rhEPO in patients with craniocerebral injury can promote the expressions of neuroglobin and hemoglobin, and decrease APACHE Ⅱ score,thus play a certain role of neuroprotection.

参考文献/References:

[1]Burmester T,Weich B,Reinhardt S,et al.A vertebrate globin expressed in the brain[J].Nature,2000,407(6803):520 [2]Fisher JW.Erythropoietin: physiology and pharmacology update[J].Exp Biol Med(Maywood),2003,228(1):1 [3]朱灵,汤永红,袁旭光,等.促红细胞生成素对大鼠脑缺血后神经元凋亡及热休克蛋白27和血管内皮生长因子表达的影响[J].中国动脉硬化杂志,2007,15(2):97 [4]Corwin HL,Gettinger A,Fabian TC,et al.Efficacy and safety of epoetin alfa in critically ill patients[J].N Engl J Med,2007,357(10):965 [5]Corwin HL,Gettinger A,Pearl RG,et al.Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial[J].JAMA,2002,288(22):2827 [6]王航雁,邓美玉,王静,等.脑红蛋白基因在人体不同细胞组织中的表达[J].实用儿科临床杂志,2004,19(4):278 [7]邓亚仙,高宝勤,杨伟力.脑红蛋白的研究进展[J].国外医学:儿科学分册,2004,31(5):272 [8]Sun Y,Jin K,Mao XO,et al.Neuroglobin is upregulated by and protects neurons from hypoxicischemic injury[J].Proc Natl Acad Sci USA,2001,98(26):15306 [9]Zhou GY,Zhou SN,Lou ZY,et al.Translocation and neuroprotective properties of transactivatoroftranscription proteintransduction domainneuroglobin fusion protein in primary cultured cortical neurons[J].Biotechnol Appl Biochem,2008,49(Pt 1):25 [10]Herold S,Fago A,Weber RE,et al.Reactivity studies of the Fe(Ⅲ)and Fe(Ⅱ)NO forms of human neuroglobin reveal a potential role against oxidative stress[J].J Biol Chem,2004,279(22):22841 [11]Fordel E,Thijs L,Martinet W,et al.Neuroglobin and cytoglobin overexpression protects human SHSY5Y neuroblastoma cells against oxidative stressinduced cell death[J].Neurosci Lett,2006,410(2):146 [12]王航雁,王静,张荣媛,等.缺血再灌注损伤大鼠脑组织脑红蛋白表达的变化[J].实用儿科临床杂志,2008,23(21):1680 [13]Lamon S,Russell AP.The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?[J].Front Physiol,2013,4:176 [14]赵玲莉,耿惠,邓丽君,等.EPO的临床研究进展[J].青海医药杂志,2011,41(3):74

备注/Memo

备注/Memo:
△女,1963年12月生,教授,主任医师,研究方向:器官保护、脓毒症,Email:rongqing.sun@126.com
更新日期/Last Update: 2014-04-23