[1]万鼎铭△,周雪芳,谢新生,等.异基因造血干细胞移植后肠球菌相关性腹泻的临床分析[J].郑州大学学报(医学版),2014,(02):284.
 WAN Dingming,ZHOU Xuefang,XIE Xinsheng,et al.Clinical analysis of enterococcus associated diarrhea in patients received allogeneic hematopoietic stem cell transplantation[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(02):284.
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异基因造血干细胞移植后肠球菌相关性腹泻的临床分析
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年02期
页码:
284
栏目:
应用研究
出版日期:
2014-03-20

文章信息/Info

Title:
Clinical analysis of enterococcus associated diarrhea in patients received allogeneic hematopoietic stem cell transplantation
作者:
万鼎铭△周雪芳谢新生孙玲孙慧曹伟杰边志磊李丽
郑州大学第一附属医院血液科 郑州 450052
Author(s):
WAN Dingming ZHOU Xuefang XIE Xinsheng SUN Ling SUN Hui CAO Weijie BIAN Zhilei LI Li
Department of Hematology,the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052
关键词:
异基因造血干细胞移植肠球菌相关性腹泻肠道菌群抗生素预处理方案
Keywords:
allogeneic hematopoietic stem cell transplantationenterococcus associated diarrhea intestinal floraantibioticpreparative regimen
分类号:
A
文献标志码:
R551.3
摘要:
目的:探讨异基因造血干细胞移植(alloHSCT)后肠球菌相关性腹泻(EAD)的临床特点,分析原因,寻求有效的防治措施。方法:对36例alloHSCT后EAD患者的临床资料进行回顾性分析,同时以36例健康人群作为对照组,观察EAD患者肠道菌群变化。同期行alloHSCT者共70例,其中全相合移植40例,单倍体移植30例。结果:alloHSCT后EAD患者肠道菌群中乳酸杆菌、双歧杆菌、类杆菌、肠杆菌等细菌数量明显下降,差异有统计学意义(P均<0.001)。全相合移植EAD发生率为40.0%,单倍体移植发生率为66.7%,差异有统计学意义(χ2=4.878,P=0.027)。EAD患者口服替考拉宁并辅助益生菌治疗均治愈。结论:EAD常见于alloHSCT后,一旦出现应积极给予对症处理。
Abstract:
Aim: To explore clinical characteristics of enterococcus associated diarrhea (EAD) in patients received allogeneic hematopoietic stem cell transplantation (alloHSCT), analyze the corresponding causes and seek effective prevention and treatment measures. Methods: Retrospective analysis was performed in 36 EAD patients who had received alloHSCT. And 36 healthy individuals with normal intestinal microflora were chosen as control group.The change of intestinal microflora in EAD patients was observed.Another 70 patients received alloHSCT,among whom,40 were HLA allmatched transplantation,and 30 were HLA haploidentical transplantation.Results: There was significant reduction in the counting of the intestinal flora such as Lactobacillus, Bifidobacterium, Bacteroides, and Enterobacter, etc(P<0.001). The EAD positive rate was 40.0% in HLA allmatched transplantation, and 66.7% in HLA haploidentical transplantation(χ2=4.878,P=0.027).Oral administration of teicoplanin supplemented with probiotics could cure those patients with EAD. Conclusion: There is high occurrence of EAD for patients received alloHSCT. Once that happens, patients should receive active treatment.

参考文献/References:

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备注/Memo

备注/Memo:
△男,1963 年5 月生,博士,教授,主任医师,研究方向:血液病和造血干细胞移植,Email:wwddmm@vip.sina.com
更新日期/Last Update: 2014-04-23