[1]陈升阳,李晓勇#,陈艳军,等.射频消融治疗局部晚期胰头癌疗效分析*[J].郑州大学学报(医学版),2014,(03):341.
 CHEN Shengyang,LI Xiaoyong,CHEN Yanjun,et al.Efficacy of radiofreqency ablation on locally advanced pancreatic head cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(03):341.
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射频消融治疗局部晚期胰头癌疗效分析*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年03期
页码:
341
栏目:
应用研究
出版日期:
2014-05-20

文章信息/Info

Title:
Efficacy of radiofreqency ablation on locally advanced pancreatic head cancer
作者:
陈升阳李晓勇#陈艳军杨战锋崔卫东周百中宋伟华
郑州大学第五附属医院肝胆胰腺外科 郑州 450052
Author(s):
CHEN ShengyangLI XiaoyongCHEN YanjunYANG ZhanfengCUI WeidongZHOU BaizhongSONG Weihua
Department of Hepatobiliary Pancreatic Surgery,the Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
胰头癌射频消融肿瘤标记物生存分析
Keywords:
pancreatic head cancer radiofreqency ablation tumor marker survival analysis
分类号:
R735.9
摘要:
摘要目的:评价射频消融(RFA)治疗局部晚期胰头癌的临床疗效。方法:将87例局部晚期胰头癌患者分为两组,一组给予RFA联合胆肠及胃肠旁路吻合术(RFA组,n=42),另一组给予单纯胆肠及胃肠吻合术(对照组,n=45);随访3~50个月,比较治疗前与治疗3个月后血清CA199和CA242水平的变化,应用KaplanMeier法绘制生存曲线并进行logrank检验。结果:RFA组治疗3个月后血清CA199和CA242水平均较对照组下降更明显(t=10.589、6.130,P<0.001)。两组患者生存曲线差异有统计学意义(χ2 =33.152,P<0.001);RFA组1、2、3 a生存率分别为77.9%、28.7%、2.4%,中位生存期为21个月(95%置信区间17.86~24.14个月);对照组1、2、3 a生存率分别为22.9%、2.2%、0.0%,中位生存期为10个月(95%置信区间8.90~11.10个月)。结论:RFA能够有效延长局部晚期胰头癌患者的生存期。
Abstract:
AbstractAim: To evaluate the clinical efficacy of radiofreqency ablation(RFA) on locally advanced pancreatic head cancer(LAPHC).Methods: A total of 87 LAPHC patients were divided into RFA group(n=42) and control group(n=45),and followed up for 3-50 months.The serum CA199 and CA242 levels preoperation and 3 months after operation were determined.Survival curve was drown by the KaplanMeier method.Results: The descent range of serum CA199 and CA242 levels of RFA group 3 months after operation were more than that of the control group(t=10.589,6.130,P<0.001). The survival curve of RFA group differed from that of the control group(χ2=33.152,P<0.001).The 1 ,2 and 3year overall cumulative survival rates in RFA group and control group were 77.9%,28.7%,2.4% and 22.9%,2.2%,0.0%,respectively;the median survival time was 21 months(95%CI was 17.86-24.14 months) in RFA group and 10 months(95%CI was 8.90-11.10 months) in control group,respectively. Conclusion: RFA can effectively prolong survival time of patients with LAPHC.

参考文献/References:

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备注/Memo

备注/Memo:
*河南省教育厅自然科学研究项目2011A320036#通讯作者,男,1964年2月生,硕士,教授,主任医师,研究方向:肝胆胰腺外科,Email:lixy64@126.com
更新日期/Last Update: 1900-01-01