[1]王海楠),祁元明)#,高艳锋),等.河南省肿瘤、慢性丙型肝炎、白癜风患者HLAA2的分布*[J].郑州大学学报(医学版),2014,(03):349.
 WANG Hainan),QI Yuanming),GAO Yanfeng),et al.Frequencies of HLAA2 among patients with tumors,chronic hepatitis C and vitiligo in Henan Province[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(03):349.
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河南省肿瘤、慢性丙型肝炎、白癜风患者HLAA2的分布*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年03期
页码:
349
栏目:
应用研究
出版日期:
2014-05-20

文章信息/Info

Title:
Frequencies of HLAA2 among patients with tumors,chronic hepatitis C and vitiligo in Henan Province
作者:
王海楠12)祁元明1)#高艳锋1)周哲骏12)李志勤3)杜军波4)李建斌5)张毅1267)#
1)郑州大学生物工程系 郑州 4500012)郑州大学第一附属医院生物治疗中心 郑州 4500523)郑州大学第一附属医院感染科 郑州 4500524)焦作煤业集团中央医院皮肤科 焦作4540005)河南省红十字血液中心 郑州4500536)郑州大学第一附属医院肿瘤科 郑州 4500527)河南省高等学校临床医学重点学科开放实验室 郑州 450052
Author(s):
WANG Hainan12)QI Yuanming1)GAO Yanfeng1)ZHOU Zhejun12)LI Zhiqin3)DU Junbo4)LI Jianbin5)ZHANG Yi1267)
1)Department of Bioengineering, Zhengzhou University, Zhengzhou 4500012)Biotherapy Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 4500523)Department of Infectious Disease, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 4500524)Department of Dermatology, Central Hospital, Jiaozuo Coal Group, Jiaozuo 4540005)Henan Red Cross Blood Center,Zhengzhou 4500536)Department of Oncology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 4500527)Institute of ClinicalMedicine of Henan Province, Zhengzhou 450052
关键词:
HLAA2肿瘤免疫治疗慢性丙型肝炎白癜风
Keywords:
AbstractAim: To investigate HLAA2 frequencies in the patients either with cancer or chronic hepatitis C or vitiligo in Henan Province.Methods: The frequencies of HLAA2 in 72 healthy people 438 patients with tumors 110 patients with chronic hepatitis
分类号:
R392
摘要:
摘要目的:分析河南地区肿瘤、慢性丙型肝炎、白癜风患者HLAA2的分布频率。方法:应用流式细胞术和聚合酶链反应/序列特异性引物(PCRSSP)技术检测分析了72例健康人(正常对照)和438例肿瘤患者、110例慢性丙型肝炎患者、97例白癜风患者外周血中HLAA2抗原的分布频率。结果:肿瘤、慢性丙型肝炎、白癜风患者中HLAA2抗原的分布频率分别为49.1%、39.0%、47.4%,与正常对照组的48.6%比较,差异均无统计学意义(χ2=0.006,1.611,0.230,P均>0.05)。病例数超过50的肺癌(91例)、胃癌(56例)和食管癌(126例)患者中HLAA2分布频率分别为42.9%、57.1%和38.0%,与正常对照比较,差异亦无统计学意义(χ2=0.537,0.919,2.081,P均>0.05)。结论:河南肿瘤、慢性丙型肝炎及白癜风患者HLAA2的分布无特异性,因此HLAA2限制性的生物细胞免疫治疗具有广泛的应用价值。
Abstract:
HLAA2;tumor;immunotherapy;chronic hepatitis C;vitiligo

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目81171986,81271815;卫生部科研攻关基金资助项目20110110001;河南省科技厅基础与前沿技术研究基金资 助项目112300410153,122300410155;河南省科技厅科技创新人才计划项目124200510006;郑州大学第一附属医院院内创新团队基金资助 项目#通讯作者:祁元明,女,1957年1月生,博士,教授,研究方向:抗原肽和多肽疫苗, Email:qymzzu@126.com;张毅,男,1964年4月生,博士,教授,研究方向:肿瘤免疫学、肿瘤干细
更新日期/Last Update: 1900-01-01