[1]樊实真),马跃华),张春玲),等.糖尿病周围神经病变筛查方法的比较*[J].郑州大学学报(医学版),2014,(03):362.
 FAN Shizhen,MA Yuehua,ZHANG Chunling,et al.Comparative studies on screening methods of diabetic peripheral neuropathy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(03):362.
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糖尿病周围神经病变筛查方法的比较*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年03期
页码:
362
栏目:
应用研究
出版日期:
2014-05-20

文章信息/Info

Title:
Comparative studies on screening methods of diabetic peripheral neuropathy
作者:
樊实真1马跃华2张春玲3张晶2赵志刚2)#
1)郑州大学第一附属医院内分泌代谢科 郑州 4500522)河南省人民医院内分泌代谢科 郑州 4500033)河南财经政法大学外语系 郑州 450003
Author(s):
FAN Shizhen1 MA Yuehua2 ZHANG Chunling3 ZHANG Jing2 ZHAO Zhigang2
1)Department of Endocrinology and Metabolism, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 4500522)Department of Endocrinology and Metabolism,Henan Provincial People's Hospital,Zhengzhou 4500033)Department of Foreign Languages,Henan University of Economics and Law, Zhengzhou 450003
关键词:
糖尿病周围神经病变筛查神经电生理检查
Keywords:
AbstractAim: To explore the best combination of diabetic peripheral neuropathy(DPN) simple screening methods from the ankle reflex vibration perception pressure sensation temperature sensation and pinprick. Methods: A total of 816 diabetic patients pe
分类号:
R587.1
摘要:
摘要目的:在踝反射、振动觉、压力觉、温度觉及刺痛觉5项简单筛查糖尿病周围神经病变(DPN)指标的基础上,探索最佳指标组合,指导临床应用。 方法:以神经电生理检查(NET)为金标准,对 816 例糖尿病患者同时进行NET和5项简单筛查,分析各项指标单用及其组合用于DPN筛查的灵敏度、特异度和约登指数,进而选出最佳组合。 结果:5项简单筛查方法和选2项、3项、4项方法的最优组合以及5项全选筛查DPN的灵敏度、特异度和约登指数如下,踝反射分别为34.05%、69.54%、0.035 9,振动觉分别为77.82%、60.93%、0.387 5,压力觉分别为19.46%、95.70%、0.151 6,温度觉分别为35.21%、89.07%、0.242 8,刺痛觉分别为31.52%、84.77%、0.162 9,踝反射+振动觉分别为86.77%、60.93%、0.477 0,踝反射+振动觉+温度觉分别为89.69%、58.94%、0.486 3,踝反射+振动觉+压力觉+温度觉分别为90.86%、58.28%、0.491 4,5项全选分别为92.22%、57.95%、0.501 7。结论:踝反射、振动觉和温度觉组合与NET符合性好,可作为筛查DPN简便、有效的方法。
Abstract:
diabetic peripheral neuropathy;screening;neural electrophysiological test

参考文献/References:

[1]夏萍,刘超,狄红杰.痛性糖尿病神经病变药物治疗进展[J].中国实用内科杂志,2013,33(8):660 [2]Callaghan BC,Cheng HT,Stables CL,et al.Diabetic neuropathy: clinical manifestations and current treatments[J].Lancet Neurol,2012,11(6):521 [3]张烁,李益明.糖尿病周围神经病变的临床检查方法[J].中国实用内科杂志,2006,26(11):858 [4]Fabian W,Majkowska L,Stefański A,et al.Prevalence of diabetes, antidiabetic treatment and chronic diabetic complications reported by general practitioners[J].Przegl Lek,2005,62(4):201 [5]Janghorbani M,Rezvanian H,Kachooei A,et al.Peripheral neuropathy in type 2 diabetes mellitus in Isfahan, Iran: prevalence and risk factors[J].Acta Neurol Scand,2006,114(6):384 [6]宁光.糖尿病周围神经病变诊断研究进展[J].中国实用内科杂志,2007,27(7):487 [7]Perkins BA,Olaleye D,Zinman B,et al.Simple screening tests for peripheral neuropathy in the diabetes clinic[J].Diabetes Care,2001,24(2):250 [8]宁光.糖尿病神经病变的诊断和治疗[J].国际内分泌代谢杂志,2006,26(3):附录32 [9]JimenezCohl P,Grekin C,Leyton C,et al.Thermal threshold: research study on small fiber dysfunction in distal diabetic polyneuropathy[J].J Diabetes Sci Technol,2012,6(1):177 [10]Tesfaye S,Boulton AJ,Dyck PJ,et al.Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments[J].Diabetes Care,2010,33(10):2285 [11]张晶,袁慧娟,张春玲,等.糖尿病周围神经病变筛查方法的临床研究[J].河南医学研究,2012,21(1):34

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备注/Memo

备注/Memo:
*国家自然科学基金项目61151003 #通讯作者,男,1957年4月生,本科,主任医师,教授,研究方向:糖尿病及其并发症,Email:zhaozhigang1957@126.com
更新日期/Last Update: 1900-01-01