[1]李留霞)△,李冰熠),李秀芳),等.上皮性卵巢癌组织中IMP1的表达[J].郑州大学学报(医学版),2014,(03):374.
 LI Liuxia),LI Bingyi),LI Xiufang),et al.Expression of IMP1 in epithelial ovarian cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(03):374.
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上皮性卵巢癌组织中IMP1的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年03期
页码:
374
栏目:
应用研究
出版日期:
2014-05-20

文章信息/Info

Title:
Expression of IMP1 in epithelial ovarian cancer tissue
作者:
李留霞1)△李冰熠1李秀芳1张兰兰1王凯娟23张建营23
1)郑州大学第一附属医院妇产科 郑州 4500522)郑州大学公共卫生学院 郑州 4500013)河南省肿瘤流行病学重点实验室 郑州 450052
Author(s):
LI Liuxia1) LI Bingyi1) LI Xiufang1) ZHANG Lanlan1) WANG Kaijuan23) ZHANG Jianying23)
1)Department of Gynecology and Obstetrics, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 4500522)College of Public Health, Zhengzhou University, Zhengzhou 4500013)Cancer Epidemiology Key Laboratory in Henan Province,Zhengzhou 450052
关键词:
上皮性卵巢癌IMP1
Keywords:
AbstractAim: To detect the expression of IMP1 in epithelial ovarian cancer tissue. Methods: The IMP1 protein and mRNA expression levels in 47 cases of epithelial ovarian cancer28 cases of benign ovarian disease and 20 cases of normal ovarian were respect
分类号:
R737.31
摘要:
摘要目的:探讨上皮性卵巢癌组织中IMP1蛋白及mRNA的表达情况。方法:采用免疫组化方法和RTPCR技术检测47例上皮性卵巢癌、28例卵巢上皮性良性肿瘤及20例正常卵巢上皮组织中IMP1蛋白和mRNA的表达情况。结果:IMP1蛋白在上皮性卵巢癌、卵巢上皮性良性肿瘤及正常卵巢上皮组织中的阳性表达率分别为85.1%、32.1%及10.0%,IMP1 mRNA在上述3种组织中的相对表达量分别为(0.652±0.067)、(0.120±0.013)、(0.085±0.011)(χ2=39.239,F=990.674,P均<0.001);且上皮性卵巢癌组织中IMP1蛋白阳性表达率、mRNA相对表达量均高于其他2种组织(P均<0.001)。不同FIGO分期和组织学分级的上皮性卵巢组织中IMP1蛋白的阳性表达率比较,差异有统计意义(χ2校正=5.645、4.365,P均<0.05)。上皮性卵巢癌组织中IMP1蛋白与mRNA表达呈正相关(rS=0.869,P<0.001)。结论:IMP1可能参与卵巢癌的发生发展过程。
Abstract:
epithelial ovarian cancer; IMP1

参考文献/References:

[1]Twu C,Han ES.Clinical utility of targeted treatments in the management of epithelial ovarian cancer[J].Biologics,2012,6:233 [2]Huang GS,BrouwerVisser J,Ramirez MJ,et al.Insulinlike growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced diseasefree survival in ovarian cancer[J].Clin Cancer Res,2010,16(11):2999 [3]Fromowitz FB, Viola MV, Chao S, et al. Ras P21 expression in the progression of breast cancer[J]. Human Pathol, 1987, 18(12):1268 [4]Zheng W,Yi X,Fadare O,et al.The oncofetal protein IMP3: a novel biomarker for endometrial serous carcinoma[J].Am J Surg Pathol,2008,32(2):304 [5]Zhou SL, Yue WB, Fan ZM, et al. Autoantibody detection to tumorassociated of P53, IMP1, P16, cyclin B1, P62,Cmyc,Survivn, and Koc for the screening of highrisk subject and early detection of esophageal squamous cell carcinoma[J].Dis Esophagus, 2013, Oct 21,doi:1111/dote.12145 [6]Hamilton KE,Noubissi FK,Katti PS,et al.IMP1 promotes tumor growth, dissemination and a tumorinitiating cell phenotype in colorectal cancer cell xenografts[J].Carcinogenesis,2013,34(11):2647 [7]Ye H,Sun C,Ren P,et al.Miniarray of multiple tumorassociated antigens (TAAs) in the immunodiagnosis of breast cancer[J].Oncol Lett,2013,5(2):663 [8]Kbel M,Weidensdorfer D,Reinke C,et al.Expression of the RNAbinding protein IMP1 correlates with poor prognosis in ovarian carcinoma[J].Oncogene,2007,26(54):7584 [9]李留霞,张兰兰,李秀芳,等.六种肿瘤相关抗原自身抗体联合CA125检测对卵巢癌早期诊断的价值[J].郑州大学学报:医学版,2013,48(2):238 [10]张建伟,申兴斌.胰岛素样生长因子结合蛋白与肿瘤发生关系的研究进展[J].承德医学院学报,2013,30(4):329 [11]Hammer NA, Hansen TO, Byskov AG, et al. Expression of IGFⅡ mRNAbinding proteins(IMPs) in gonads and testicular cancer[J]. Reproduction, 2005, 130(2):203

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备注/Memo

备注/Memo:
△女,1962年11月生,博士,主任医师,教授,研究方向:妇科肿瘤及妇科内分泌,Email:llxia698@163.com
更新日期/Last Update: 1900-01-01