[1]苏磊,耿曼英#,张俊星,等.盐酸赛洛唑啉联合鼻用糖皮质激素对变应性鼻炎模型大鼠鼻黏膜组织中ICAM1、IL12表达的影响[J].郑州大学学报(医学版),2014,(03):380.
 SU Lei,GENG Manying,ZHANG Junxing,et al.Effects of combination of xylometazoline hydrochloride and nasal corticosteroids on expressions of ICAM1 and IL12 in nasal mucosa from rats with allergic rhinitis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(03):380.
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盐酸赛洛唑啉联合鼻用糖皮质激素对变应性鼻炎模型大鼠鼻黏膜组织中ICAM1、IL12表达的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年03期
页码:
380
栏目:
应用研究
出版日期:
2014-05-20

文章信息/Info

Title:
Effects of combination of xylometazoline hydrochloride and nasal corticosteroids on expressions of ICAM1 and IL12 in nasal mucosa from rats with allergic rhinitis
作者:
苏磊耿曼英#张俊星张慧孟令浩
郑州大学第二附属医院耳鼻咽喉科 郑州 450014
Author(s):
SU LeiGENG ManyingZHANG JunxingZHANG HuiMENG Linghao
Department of Otolaryngology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014
关键词:
盐酸赛洛唑啉鼻用糖皮质激素变应性鼻炎细胞间黏附分子1白细胞介素12大鼠
Keywords:
AbstractAim: To investigate the effects of xylometazoline hydrochloride combined with nasal corticosteroids in the treatment of allergic rhinitis. Methods: A total of 60 SD rats were randomly allocated into 3 groups 20 rats in each group. Using OVA + Al(
分类号:
R765.21
摘要:
摘要目的:探讨盐酸赛洛唑啉联合鼻用糖皮质激素治疗变应性鼻炎(AR)的疗效。方法:60只健康SD大鼠随机分成A、B、C 3组,每组20只。以卵清白蛋白+Al(OH)3建立大鼠AR模型后, B组用糠酸莫米松治疗,C组用盐酸赛洛唑啉联合糠酸莫米松治疗,A组以生理盐水代替,共治疗1周。采用HE染色方法观察3组大鼠鼻黏膜组织中嗜酸性粒细胞(EOS)浸润情况;用免疫组化SP法检测大鼠鼻黏膜组织中细胞间黏附分子1(ICAM1)、白细胞介素12(IL12)的表达水平。结果:与A组比较,B、C两组大鼠鼻黏膜组织中EOS浸润较少,C组较B组更少(F=3 001.500,P<0.001);A组鼻黏膜组织中ICAM1的表达量明显高于B、C组 (P<0.05),其中C组ICAM1表达量极少(F=4 458.820,P<0.001);A组鼻黏膜组织中IL12的表达量极少,C组IL12表达量最高(F=6 640.770,P<0.001)。结论:盐酸赛洛唑啉联合鼻用糖皮质激素治疗可有效降低AR的鼻黏膜炎症反应,其疗效优于单纯运用鼻用糖皮质激素。
Abstract:
xylometazoline hydrochloride;nasal corticosteroid;allergic rhinitis;ICAM1;IL12;rat

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,女,1963年1月生,教授,主任医师,研究方向:变应性鼻炎基础研究及治疗,Email:manying66@126.com
更新日期/Last Update: 1900-01-01