[1]万鼎铭)△,边志磊),刘延方),等.急性髓系白血病患者骨髓WT1基因的表达与预后的关系[J].郑州大学学报(医学版),2014,(03):386.
 WAN Dingming),BIAN Zhilei),LIU Yanfang),et al.Prognostic value of WT1 expression in bone marrow for acute myeloid leukemia[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(03):386.
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急性髓系白血病患者骨髓WT1基因的表达与预后的关系
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年03期
页码:
386
栏目:
应用研究
出版日期:
2014-05-20

文章信息/Info

Title:
Prognostic value of WT1 expression in bone marrow for acute myeloid leukemia
作者:
万鼎铭1)△边志磊1)刘延方1)曹伟杰1)张媛2)李涛13)何海燕1)玄中乾1)
1)郑州大学第一附属医院血液科 郑州 4500522)新乡医学院第一附属医院血液科 新乡 4531003) 郑州大学血液病研究所 郑州 450052
Author(s):
WAN Dingming1)BIAN Zhilei1)LIU Yanfang1)CAO Weijie1)ZHANG Yuan2LI Tao13HE Haiyan1)XUAN Zhongqian1)
1)Department of Hematology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Hematology,the First Affiliated Hospital,Xinxiang Medical University,Xinxiang 453100 3)Institute of Hematology,Zhengzhou University,Zhengzhou 450052
关键词:
急性髓系白血病WT1基因预后
Keywords:
AbstractAim: To investigate the relationship between WT1 gene expression level in bone marrow of acute myeloid leukemia (AML) patients and the prognosis. Methods: A total of 122 newly diagnosed AML patients were subjected to detect WT1 expression level i
分类号:
R557.3
摘要:
摘要目的:探讨急性髓系白血病(AML)患者骨髓WT1基因的表达与预后的关系。方法:应用实时定量逆转录PCR方法检测122例初诊AML患者骨髓WT1基因的表达水平,并进行初次诱导化疗缓解率(CR1)及2 a无白血病生存率(LFS)和总生存率(OS)的分析。对照组为21例非白血病患者或造血干细胞移植健康供者。结果:对照组骨髓WT1基因表达水平为0.007(0.002,0.080);AML组为0.677(0.336,0.763),明显高于对照组(Z=2.620,P<0.001)。AMLM3患者WT1基因高表达组与低表达组CR1、2 a LFS和OS无差异。AML(非M3)患者WT1基因低表达组CR1为82.6%(38/46),高表达组为52.3%(23/44),两组比较,差异有统计学意义(χ2=9.476,P=0.002);两组的总生存曲线和无白血病生存曲线差异有统计学意义(χ2=5.410、4.698,P<0.05),高表达组2 a OS(36.0%)和LFS(33.3%)均低于低表达组(57.7%和53.7%)。结论:骨髓WT1基因表达水平是预测AML预后的有效监测指标。
Abstract:
acute myeloid leukemia;WT1 gene;prognosis

参考文献/References:

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备注/Memo

备注/Memo:
△男,1963年5月生,博士,教授,主任医师,研究方向:血液病和造血干细胞移植的基础和临床,Email:wwddmm@vip.sina.com
更新日期/Last Update: 1900-01-01