[1]邓克红,崔金全#,卢书芳.宫颈鳞癌组织中TS和TopoⅡα的表达与新辅助化疗效果的关系[J].郑州大学学报(医学版),2014,(03):400.
 DENG Kehong,CUI Jinquan,LU Shufang.Relationship between expressions of TS and TopoⅡα in cervical squamous cancer tissue and curative effect of neoadjuvant chemotherapy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(03):400.
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宫颈鳞癌组织中TS和TopoⅡα的表达与新辅助化疗效果的关系
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年03期
页码:
400
栏目:
应用研究
出版日期:
2014-05-20

文章信息/Info

Title:
Relationship between expressions of TS and TopoⅡα in cervical squamous cancer tissue and curative effect of neoadjuvant chemotherapy
作者:
邓克红崔金全#卢书芳
郑州大学第二附属医院妇产科 郑州 450014
Author(s):
DENG KehongCUI Jinquan LU Shufang
Department of Gynecology and Obstetrics,the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
关键词:
宫颈鳞癌新辅助化疗化疗疗效胸苷酸合成酶DNA拓扑异构酶Ⅱα
Keywords:
AbstractAim: To explore relationship between the expressions of TS and TopoⅡα in cervical squamous cancer tissue and the efficacy of neoadjuvant chemotherapy(NACT) of taxol and carbon(TC). Methods: TS and TopoⅡα expressions in 54 specimens of cervical sq
分类号:
R737.33
摘要:
摘要目的:探讨宫颈鳞癌组织中胸苷酸合成酶(TS)和DNA拓扑异构酶Ⅱα(TopoⅡα)的表达与新辅助化疗效果的关系。方法:采用免疫组化SP法检测54例宫颈鳞癌患者宫颈组织中TS、TopoⅡα的表达。结果:54例宫颈鳞癌患者中34例对NACT有反应,总有效率为72.2%,无效率为27.8%。宫颈癌患者组织中TS、TopoⅡα的表达水平与NACT疗效有关(χ2=7.020和9.026,P<0.05)。TS低表达者的化疗有效率高于高表达者,TopoⅡα高表达者的化疗有效率高于低表达者。结论:TS低表达和TopoⅡα高表达的患者均可从NACT中获益,两者是否可以作为宫颈癌患者NACT疗效指标值得进一步研究。
Abstract:
cervical squamous cancer;neoadjuvant chemotherapy;chemotherapy efficacy;TS;TopoⅡα

参考文献/References:

[1]Neoadjuvant Chemotherapy for Cervical Cancer Metaanalysis Collaboration.Neoadjuvant chemotherapy for locally advanced cervical cancer:a systematic renew and metaanalysis of individual patient data from 21 randomised trials[J].Eur J Cancer,2003,39(17):2470 [2]张占薪,罗大虎,张占化,等.局部晚期宫颈癌新辅助化疗39例[J].郑州大学学报:医学版,2010,45(4):681 [3]Therasse P,Arbuck SG,Eisenhauer EA,et al.New guidelines to evaluate the response to treatment in solid tumors[J].J Natl Cancer Inst,2000,92(3):205 [4]贾坤,梁坤,张广美.Ⅰb2Ⅱb期宫颈癌新辅助化疗的临床应用[J].中国临床研究,2012,25(4):344 [5]Gong L,Lou JY,Wang P,et al.Clinical evaluation of neoadjuvant chemotherapy followed by radical surgery in the management of stage Ⅰb2Ⅱb cervical cancer[J].Int J Gynaecol Obstet,2012,117(1):23 [6]高国兰,万红英,黄传生,等.Pgp、GSTπ、TS蛋白在宫颈癌中的表达及临床意义[J].临床肿瘤学杂志,2007,12(1):23 [7]Peters GJ,Backus HH,Freemantle S,et al.Induction of thymidylate synthase as a 5fluorouracil resistance mechanism[J].Biochim Biophys Acta,2002,1587(2/3):194 [8]Kuramochi H,Tanaka K,Oh D,et al.Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients[J].Int J Oncol,2008,32(1):201 [9]钱晓萍,严爱婷,谢丽,等.TS mRNA表达与食管鳞癌患者5FU化疗临床预后的相关研究[J].现代肿瘤医学,2012,20(10):2062 [10]陈慧君,吴绪峰,陈惠祯.卵巢癌中TopoⅡα、GSTπ、Pgp表达与化疗反应性及预后的关系[J].肿瘤,2006,26(4):380 [11]郭慈仁,陈桂林,黄燕玲,等.Pgp、GSTπ和Topo Ⅱ在巨块型宫颈癌中的表达及其与新辅助化疗的关系[J].疑难病杂志,2013,12(2):120 [12]刘真真,刘慧,李连方,等.多药耐药类蛋白对乳癌新辅助化疗疗效的影响[J].郑州大学学报:医学版,2005,40(5):850 [13]Wang B,Perchellet EM,Wang Y,et al.Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase ⅠandⅡactivities[J].Anticancer Drugs,2003,14(7):503

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备注/Memo

备注/Memo:
#通讯作者,女,1962年11月生,博士,教授,研究方向:妇科肿瘤,Email:jinquan_cui@163.com
更新日期/Last Update: 1900-01-01