[1]梁丽),顾福嘉),黄国美)#,等.脐血干细胞移植治疗失代偿期肝硬化效果观察*[J].郑州大学学报(医学版),2014,(04):552.
 LIANG Li,GU Fujia,HUANG Guomei,et al.Efficacy of umbilical cord blood stem cell transplantation for decompensated cirrhosis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(04):552.
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脐血干细胞移植治疗失代偿期肝硬化效果观察*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年04期
页码:
552
栏目:
应用研究
出版日期:
2014-07-20

文章信息/Info

Title:
Efficacy of umbilical cord blood stem cell transplantation for decompensated cirrhosis
作者:
梁丽1)顾福嘉2)黄国美1)#杨大平1)张玲玲1)袁军3)
1)贵州省人民医院消化内科 贵阳 5500022)贵州省人民医院介入科 贵阳 5500023)贵州省人民医院中心实验室 贵阳 550002
Author(s):
LIANG Li1)GU Fujia2)HUANG Guomei1)YANG Daping1)ZHANG Lingling1)YUAN Jun3)
1)Department of Gastroenterology,Guizhou Provincial People's Hospital,Guiyang 5500022)Department of Intervention,Guizhou Provincial People's Hospital,Guiyang 5500023)Department of Central Laboratory,Guizhou Provincial People's Hospital,Guiyang 550002
关键词:
脐血干细胞肝硬化负筛选混合法
Keywords:
umbilical cord blood stem cellcirrhosisnegative screening mixing method
分类号:
R575.2
摘要:
目的:探讨脐血干细胞移植治疗失代偿期肝硬化的效果。 方法:30例Child C级失代偿期肝硬化患者经传统内科综合治疗,效果不佳。无菌采脐血,采用负筛选混合法分离、纯化脐血干细胞。对30例行术前检查除外恶性肿瘤、其他重要脏器功能衰竭等禁忌证后,在数字减影血管造影下经肝动脉灌注1×107个脐血干细胞。术后1周、2周、4周、8周、12周、半年、1 a定期随访,观察患者症状、体征及相关实验室指标改善情况和不良反应发生情况。结果:所有病例未发生与干细胞治疗相关的并发症及不良反应。术后1周开始,患者乏力、纳差、腹胀等症状逐渐改善,4周时明显缓解;血清白蛋白水平逐渐升高(F=306.080,P<0.001);21例伴顽固性腹水的患者腹水明显减少;术后1 a,15例肝功能恢复至Child A级,12例恢复至Child B级。结论:脐血干细胞移植治疗失代偿期肝硬化安全、有效。
Abstract:
Aim: To investigate the efficacy of umbilical cord blood stem cell transplantation for decompensation cirrhosis. Methods: Sterile umbilical cord blood was collected, and umbilical cord blood stem cells were separated and purified using negative screening mixing method. Thirty cases of Child C class decompensation cirrhosis patients with poor results after combined treatment of traditional medicine, were tested to exclude contraindications such as cancer, other important organ failure, etc., and then were infused with 1×107 umbilical cord blood stem cells through hepatic arterial under digital subtraction angiography. The patients were followed up at the1st, 2nd, 4th, 8th,12th week, and 0.5 year,1 year after the transplantation, the symptoms and signs, adverse effects, related laboratory indicators were observed or tested. Results: No complications or adverse effects related to stem cell transplantation therapy was found in any patient. Beginning from 1st week after the transplantation, fatigue, anorexia, abdominal distension and other symptoms were gradually improved, and greatly relieved at the 4th week after the transplantation. The serum albumin level gradually increased(F=306.080,P<0.001). Ascites was effectively controlled in 21 patients with refractory ascites. Fifteen cases recovered to Child A class and 12 cases to Child B class one year after the transplantation. Conclusion: Umbilical cord blood stem cell transplantation is safe and effective for decompensation cirrhosis.

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备注/Memo

备注/Memo:
*贵州省科技厅联合基金项目黔科合LS字[2011]013;贵阳市科技计划项目筑科合同[2011103]39;#通讯作者,女,1955年7月生,主任医师,教授,研究方向:慢性肝病的诊治,Email:xhhuanggm@163.com
更新日期/Last Update: 1900-01-01