[1]宁殿宾△,陈英敏,暴雷.乳癌患者原发灶、复发灶中VEGF与CathD蛋白的表达[J].郑州大学学报(医学版),2014,(04):563.
 NING Dianbin,CHEN Yingmin,BAO Lei.Expressions of VEGF and CathD in primary and recurrent focuses from patients with breast cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(04):563.
点击复制

乳癌患者原发灶、复发灶中VEGF与CathD蛋白的表达
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年04期
页码:
563
栏目:
应用研究
出版日期:
2014-07-20

文章信息/Info

Title:
Expressions of VEGF and CathD in primary and recurrent focuses from patients with breast cancer
作者:
宁殿宾△陈英敏暴雷
河北省人民医院普外一科 石家庄 050051
Author(s):
NING DianbinCHEN YingminBAO Lei
Department of General Surgery, Hebei Provincial People's Hospital, Shijiazhuang 050051
关键词:
乳癌血管内皮生长因子组织蛋白酶D淋巴结转移
Keywords:
breast cancer VEGF CathD lymph node metastasis
分类号:
R737.9
摘要:
目的:检测乳癌患者原发灶、复发灶中VEGF、组织蛋白酶D(CathD)蛋白的表达。方法:采用免疫组化SP法检测38例乳癌患者(有淋巴结转移者25例)和22例乳癌胸壁复发患者(有淋巴结转移者5例)原发灶、复发灶及有、无淋巴结转移组织中VEGF、CathD蛋白的表达。结果:正常乳腺组织,乳癌原发灶、复发灶中VEGF、CathD蛋白的表达差异有统计学意义(χ2=50.029和24.461,P<0.05),且乳癌原发灶、复发灶中VEGF、CathD蛋白的表达均高于正常乳腺组织,但二组织间差异无统计学意义。乳癌患者有淋巴结转移组VEGF、CathD蛋白的表达高于无淋巴结转移组(χ2=9.017和5.963,P<0.05)。乳癌组织中VEGF和CathD蛋白的表达呈正关联(rP =0.411,P<0.001)。结论:乳癌原发灶、复发灶及有淋巴结转移的乳癌组织中VEGF与CathD蛋白高表达,二者可能在乳癌复发和淋巴结转移中起协同作用。
Abstract:
Aim: To investigate the expressions of VEGF and CathD in primary and recurrent focuses from patients with breast cancer. Methods: Immunohistochemical SP method was used to detect the expressions of VEGF and CathD in 38 cases of breast cancer(25 with lymph node metastasis) and 22 cases of recurrent breast cancer(5 with lymph node metastasis).Results: The expressions of VEGF and CathD in primary focuses and recurrent focuses had no significant difference, but both of them were higher than normal breast tissue(χ2=50.029 and 24.461,P<0.05). The expressions of VEGF and CathD in breast cancer tissue with lymphatic metastasis were higher than that of without lymphatic metastasis(χ2=9.017 and 5.963,P<0.05). The expressions of VEGF and CathD in breast cancer tissue were positively associated(rP=0.411,P<0.001). Conclusion: There are high expressions of VEGF and CathD in primary, recurrent focuses and breast cancer tissue with lymph node metastasis from patients with breast cancer,and they may have synergetic effect on the recurrence and lymphatic metastasis of breast cancer.

参考文献/References:

[1]张敏璐,黄哲宙,郑莹.中国2008年女性乳腺癌发病、死亡和患病情况的估计及预测[J].中华流行病学杂志,2012,33(10):1049 [2]乌拉木,余科达,沈镇宙,等.组织蛋白酶D在乳腺导管内癌及伴早期浸润中的表达及其与复发转移的关系[J].中国癌症杂志,2010,20(4):247 [3]李颖嘉,杨莉,夏琼,等.乳腺肿瘤血管生成功能性变化特征及其机制[J].南方医科大学学报,2009,29(8):1557 [4]李颖嘉,文戈,王倩.VEGF及其主要受体Flk1/KDR在乳腺良恶性肿瘤中的表达及其意义[J].南方医科大学学报,2009,29(1):70 [5]黄柏强,贺勇,郝秀静,等.乳腺癌及癌旁组织中VEGF及survivin2B mRNA的表达意义[J].第四军医大学学报,2008,29(16):1479 [6]雷杰,费建东,刘振显,等.乳腺癌组织中Ang2及VEGF的表达及意义[J].肿瘤防治研究,2008,35(4):263 [7]Masson O,Prébois C,Derocq D,et al.CathepsinD, a key protease in breast cancer, is upregulated in obese mouse and human adipose tissue, and controls adipogenesis[J].PLoS One,2011,6(2):e16452 [8]Brujan I,Margaritescu C,Simionescu C,et al.CathepsinD expression in breast lesion: an immunohistochemical study[J].Rom J Morphol Embryol,2009,50(1):31 [9]李伟汉.乳腺癌患者癌组织中组织蛋白酶D和基质金属蛋白酶2的表达及其判断预后的价值[J].中国老年学杂志,2012,32(4):719 [10]Sullu Y,Demirag GG,Yildirim A,et al.Matrix metalloproteinase2(MMP2) and MMP9 expression in invasive ductal carcinoma of the breast[J].Pathol Res Pract,2011,207(12):747 [11]于湛,高剑波,陈奎生,等.胃癌的螺旋CT征象与MMP9及CathD蛋白表达的关系[J].郑州大学学报:医学版,2010,45(6):1004

相似文献/References:

[1]沈智勇))△,张建兵),季秀珍),等.乳癌彩超血流信号与Survivin表达及淋巴结转移的关系[J].郑州大学学报(医学版),2010,(01):97.
 SHEN Zhiyong),ZHANG Jianbing),JI Xiuzhen),et al.Relationship among blood flow imaging of CDFI,expression of Survivin and lymph node metastasis in breast carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):97.
[2]王艳梅,万鼎铭#.急性白血病患者骨髓单个核细胞中基质细胞衍生因子1和血管内皮生长因子的表达[J].郑州大学学报(医学版),2010,(01):118.
 WANG Yanmei,WAN Dingming.Expression of SDF1 and VEGF in the bone marrow mononuclear cells of patients with acute leukemia[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):118.
[3]张勇,娄卫华#,李爱霞.罗格列酮对Hep2细胞核因子κB和血管内皮生长因子mRNA表达的影响[J].郑州大学学报(医学版),2010,(02):262.
 ZHANG Yong,LOU Weihua,LI Aixia.Effects of rosiglitazone on mRNA expressions of nuclear factorκB and vascular endothelial growth factor in Hep2 cells[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):262.
[4]韩娜,王健,张中冕,等.多西紫杉醇联合卡培他滨治疗对蒽环类耐药的晚期乳癌23例[J].郑州大学学报(医学版),2010,(02):329.
[5]郝燕燕△,付蓉花,卢振威,等.α硫辛酸对早期糖尿病性视网膜病变大鼠视网膜组织血管内皮生长因子和蛋白激酶C表达的影响[J].郑州大学学报(医学版),2009,(06):1201.
 HAO Yanyan,FU Ronghua,LU Zhenwei,et al.Effects of αlipoic acid on expression of VEGF and protein rinase C in retinal tissue from rats with earlier period diabetic retinopathy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):1201.
[6]赵丹),周云)#,罗执芬).低剂量替尼泊苷联合沙利度胺对人胃癌移植瘤的抑制作用[J].郑州大学学报(医学版),2009,(05):951.
 ZHAO Dan),ZHOU Yun),LUO Zhifen).Inhibitory effect of thalidomide combined with lowdose teniposide on transplanted human gastric adenocarcinoma BGC823 tumor in nude mice[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):951.
[7]杨利霞)△,骈林萍),李超).肝细胞癌多普勒超声影像与微血管密度、血管内皮生长因子表达的相关性分析[J].郑州大学学报(医学版),2009,(05):1006.
 YANG Lixia),PIAN Linping),LI Chao).Relationship between tumoral vascularity with Doppler sonography,MVD and expression of VEGF in primary hepatocarcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):1006.
[8]刘萃红),苟建军),张辉),等.浅表膀胱移行细胞癌组织中血管内皮生长因子、Survivin和碱性成纤维细胞生长因子蛋白检测[J].郑州大学学报(医学版),2009,(05):1047.
 LIU Cuihong),GOU Jianjun),ZHANG Hui),et al.Detection of VEGF,Survivin and bFGF in superficial bladder transitional cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):1047.
[9]王婷),赵玉兰)#,海冰峰),等.坎地沙坦对大鼠肥厚心肌组织中低氧诱导因子1α、血管内皮生长因子表达的影响[J].郑州大学学报(医学版),2009,(02):383.
 WANG Ting),ZHAO Yulan),HAI Bingfeng),et al.Effects of Candesartan on expression of hypoxia inducible factor1α and vascular endothelial growth factor in hypertrophic myocardium of rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):383.
[10]赵玉兰)△,王婷),程劲松),等.阿托伐他汀对大鼠肥厚心肌组织HIF1α、VEGF表达的影响[J].郑州大学学报(医学版),2009,(02):402.
 ZHAO Yulan),WANG Ting),CHENG Jinsong),et al.Effect of Atorvastatin on expression of HIF1α,VEGF in hypertrophic myocardium of rat[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):402.

备注/Memo

备注/Memo:
△男,1973年10月生,硕士,副主任医师,研究方向:乳腺肿瘤,Email:ningdianbin@163.com
更新日期/Last Update: 1900-01-01