[1]吴干斌△,周建华,刘科兰.河南汉族冠心病患者CYP2C19基因多态性分布[J].郑州大学学报(医学版),2014,(04):568.
 WU Ganbin,ZHOU Jianhua,LIU Kelan.Distribution of CYP2C19 genetic polymorphism in patients of Han nationality with coronary artery disease from Henan Province[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(04):568.
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河南汉族冠心病患者CYP2C19基因多态性分布
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年04期
页码:
568
栏目:
应用研究
出版日期:
2014-07-20

文章信息/Info

Title:
Distribution of CYP2C19 genetic polymorphism in patients of Han nationality with coronary artery disease from Henan Province
作者:
吴干斌△周建华刘科兰
郑州大学第二附属医院药学部 郑州 450014
Author(s):
WU Ganbin ZHOU Jianhua LIU Kelan
Department of Pharmacy,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014
关键词:
CYP2C19基因多态性氯吡格雷河南省冠心病
Keywords:
CYP2C19genetic polymorphismclopidogrelHenan Provincecoronary artery disease
分类号:
R969.1
摘要:
目的:研究河南冠心病患者氯吡格雷代谢相关基因CYP2C19基因多态性的分布。方法:采用PCRRFLP技术检测600名来自河南的冠心病患者CYP2C19的基因型。结果:CYP2C19*1/*1占42.6%、CYP2C19*1/*2占40.9%、CYP2C19*1/*3占6.5%、CYP2C19*2/*2占7.2%、CYP2C19*2/*3占2.5%、CYP2C19*3/*3占0.3%。结论:河南省人群CYP2C19基因多态性的分布与全国其他地区基本一致。
Abstract:
Aim: To survey the genetic polymorphism of CYP2C19 gene in the patients with coronary artery disease from Henan Province. Methods: The CYP2C19 genotypes of 600 patients with coronary artery disease from Henan Province were determined by PCRRFLP. Results: The frequencies of CYP2C19*1/*1,*1/*2,*1/*3,*2/*2,*2/*3 and *3/*3 were 42.6%,40.9%,6.5%,7.2%,2.5% and 0.3%,respectively. Conclusion: There are no significant differences in the distribution of CYP2C19 polymorphism between Henan and other areas of China.

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备注/Memo

备注/Memo:
△男,1967年9月生,硕士,副主任药师,研究方向:临床药学,Email:wganbin521@sina.com
更新日期/Last Update: 1900-01-01