[1]马瑞兰△,李国权,张海琛,等.血浆催乳素水平与绝经后女性乳癌危险性的关系[J].郑州大学学报(医学版),2014,(04):574.
 MA Ruilan,LI Guoquan,ZHANG Haichen,et al.Relationship between plasma prolactin level and risk of breast cancer among postmenopausal women[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(04):574.
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血浆催乳素水平与绝经后女性乳癌危险性的关系
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年04期
页码:
574
栏目:
应用研究
出版日期:
2014-07-20

文章信息/Info

Title:
Relationship between plasma prolactin level and risk of breast cancer among postmenopausal women
作者:
马瑞兰△李国权张海琛邹丽娟
大连医科大学附属二院肿瘤放疗科 大连 116023
Author(s):
MA RuilanLI GuoquanZHANG HaichenZOU Lijuan
Department of Radiation Oncology,the Second Affiliated Hospital,Dalian Medical University,Dalian 116023
关键词:
乳癌危险因素催乳素绝经后女性
Keywords:
breast cancer risk factor prolactin postmenopausal women
分类号:
R737.9
摘要:
目的:评价血浆催乳素(PRL)水平与绝经后女性乳癌危险性的关系。 方法:采用化学发光法测定83例绝经后女性乳癌病例和85例对照的血浆PRL水平,应用logistic回归分析绝经后血浆PRL水平与乳癌危险性的关系。根据肿瘤临床病理特征(肿瘤大小、病理类型、肿瘤分级以及ER是否阳性)对病例组进行分组,评估血浆PRL水平与不同乳癌亚组危险性的关系。结果:①病例组血浆PRL水平高于对照组(t=2.104,P=0.037)。②以血浆PRL0.05)。结论:血浆PRL水平与绝经后女性乳癌的危险性呈正相关,尤其是ER+的乳癌。
Abstract:
Aim: To estimate the association of plasma prolactin level with risk of breast cancer among postmenopausal women. Methods: By casecontrol study,the level of plasma prolactin was measured in 83 postmenopausal breast cancer patients and 85 controls by chemiluminescence. Logistic regression models were used to examine association of prolactin with breast cancer risk. In addition, we estimated the association across various case groups(ductal vs lobular, tumor size≤2 cm vs >2 cm, ER+ vs ER-, well/moderately differentiated vs poorly differentiated). Results: The plasma prolactin level of case group was significantly higher than that of control group(t=2.104,P=0.037). Increased risk of breast cancer was positively associated with elevated plasma level of prolactin[with

参考文献/References:

[1]Clevenger CV,Furth PA,Hankinson SE,et al.The role of prolactin in mammary carcinoma[J].Endocr Rev,2003,24(1):1 [2]Tworoger SS,Hankinson SE.Prolactin and breast cancer risk[J].Cancer Lett,2006,243(2):160 [3]Bhatavdekar JM,Patel DD,Shah NG,et al.Prolactin as a local growth promoter in patients with breast cancer: GCRI experience[J].Eur J Surg Oncol,2000,26(6):540 [4]Llovera M,Touraine P,Kelly PA,et al.Involvement of prolactin in breast cancer: redefining the molecular targets[J].Exp Gerontol,2000,35(1):41 [5]RoseHellekant TA,Arendt LM,Schroeder MD,et al.Prolactin induces ER alphapositive and ER alphanegative mammary cancer in transgenic mice[J].Oncogene,2003,22(30):4664 [6]Gutzman JH,Miller KK,Schuler LA.Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor α and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells[J].J Steroid Biochem Mol Biol,2004,88(1):69 [7]Bernichtein S,Touraine P,Goffin V.New concepts in prolactin biology[J].J Endocrinol,2010,206(1):1 [8]Tworoger SS,Eliassen AH,Zhang X,et al.A 20year prospective study of plasma prolactin as a risk marker of breast cancer development[J].Cancer Res,2013,73(15):4810 [9]Gill S,Peston D,Vonderhaar BK,et al.Expression of prolactin receptors in normal, benign, and malignant breast tissue: an immunohistological study[J].J Clin Pathol,2001,54(12):956 [10]Rasmussen LM,Frederiksen KS,Din N,et al.Prolactin and oestrogen synergistically regulate gene expression and proliferation of breast cancer cells[J].Endocr Relat Cancer,2010,17(3):809 [11]González L,Zambrano A,LazaroTrueba I,et al.Activation of the unliganded estrogen receptor by prolactin in breast cancer cells[J].Oncogene,2009,28(10):1298

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备注/Memo

备注/Memo:
△女,1981年10月生,硕士,主治医师,研究方向:乳癌的临床研究,Email:maruilan2000@163.com
更新日期/Last Update: 1900-01-01