[1]贾欣),韩淑萍),孙惠斌),等.肺癌荷瘤小鼠体内组织中2甲氧基雌二醇纳米混悬剂的分布*[J].郑州大学学报(医学版),2014,(06):792.
 JIA Xin),HAN Shuping),SUN Huibin),et al.Tissue distribution of 2methoxyestradiol nanosuspension in mice bearing Lewis cell line[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(06):792.
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肺癌荷瘤小鼠体内组织中2甲氧基雌二醇纳米混悬剂的分布*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年06期
页码:
792
栏目:
论著
出版日期:
2014-11-20

文章信息/Info

Title:
Tissue distribution of 2methoxyestradiol nanosuspension in mice bearing Lewis cell line
作者:
贾欣1)韩淑萍1)孙惠斌2)王宇辉1)张超锋1)杜斌1)#
1)郑州大学药学院 郑州 4500012)郑州市第二人民医院药剂科 郑州 450006
Author(s):
JIA Xin1) HAN Shuping1) SUN Huibin2) WANG Yuhui1) ZHANG Chaofeng1)DU Bin1)
1)School of Pharmacy, Zhengzhou University, Zhengzhou 4500012)Department of Pharmacy,Zhengzhou Second People′s Hospital, Zhengzhou 450006
关键词:
2甲氧基雌二醇纳米混悬剂荷瘤小鼠组织分布肺癌
Keywords:
2methoxyestradiolnanosuspensiontumorbearing mousetissue distributionlung cancer
分类号:
R927.2;R979.1
摘要:
目的:考察2甲氧基雌二醇(2ME)纳米混悬剂在肺癌荷瘤小鼠体内组织的分布特征。方法:70只昆明小鼠制作Lewis肺癌荷瘤鼠模型后随机分为2组,实验组小鼠尾静脉注射40 mg/kg的2ME纳米混悬剂,对照组同法给予2ME溶液。给药5、15、30、60、120、240、480 min后处死小鼠,取心、肝、脾、肺、肾、胃、脑及瘤组织,HPLC法测定血浆及上述组织中药物的质量浓度,计算总靶向效率和相对摄取率。结果:与对照组相比,实验组瘤体的总靶向效率由4.26%提高至15.20%,肺组织的总靶向效率由22.24%提高至50.32%;心、肝、脾、肺、脑、瘤组织的相对摄取率均大于1,瘤组织的相对摄取率最大。结论:制备的2ME纳米混悬剂具有良好的瘤、肺靶向性。
Abstract:
Aim:To investigate tissue distribution character of 2methoxyestradiol(2ME) nanosuspension in mice bearing Lewis cell line.Methods:Seventy Kunming mice were set up Lewis lung cancer model and randomly allocated into two groups.2ME nanosuspension at 40 mg/kg or 2ME solution were administered through tail vein of rats. Blood and tissue samples were obtained at 5,15,30,60,120,240 and 480 min after the administration and the concentrations of 2ME in the above samples were determined,and the targeting performance of 2ME nanosuspension was evaluated.Results:Compared with control group,the overall targeting efficiency of the experimental group improved from 4.26% to 15.20% in tumor tissue,and improved from 22.24% to 50.32% in lung tissue.Re of 2ME nanosuspension for the heart,liver,lung,spleen,brain,and tumor tissue was all above 1,among which,re for tumor tissue was the highest.Conclusion:2ME nanosuspension has tissue targeting efficiency in tumor and lung.

参考文献/References:

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相似文献/References:

[1]王文佳,张正全,贾欣#,等.2甲氧基雌二醇对4T1、SPCA1和PC3细胞的生长抑制作用[J].郑州大学学报(医学版),2012,(06):804.
 WANG Wenjia,ZHANG Zhengquan,JIA Xin,et al.Growth inhibition effects of 2methoxyestradiol on 4T1,SPCA1 and PC3 cells[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(06):804.

备注/Memo

备注/Memo:
*郑州市科技创新团队项目121PCXTD521;#通讯作者,女,1968年2月生,博士,教授,研究方向:抗肿瘤药物的研发,Email:dubin@zzu.edu.cn
更新日期/Last Update: 2014-11-26