[1]胡滨△,崔金全,邓克红,等.宫颈癌组织高危型HPV感染与HWAPL蛋白表达的关系[J].郑州大学学报(医学版),2014,(06):862.
 HU Bin,CUI Jinquan,DENG Kehong,et al.Relationship of highrisk HPV infection and HWAPL protein expression in cervical cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(06):862.
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宫颈癌组织高危型HPV感染与HWAPL蛋白表达的关系
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年06期
页码:
862
栏目:
应用研究
出版日期:
2014-11-20

文章信息/Info

Title:
Relationship of highrisk HPV infection and HWAPL protein expression in cervical cancer tissue
作者:
胡滨△崔金全邓克红石莹莹
郑州大学第二附属医院妇产科 郑州 450014
Author(s):
HU Bin CUI Jinquan DENG Kehong SHI Yingying
Department of Gynecology and Obstetrics, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
关键词:
宫颈癌HPVHWAPL
Keywords:
cervical cancer HPV HWAPL
分类号:
R737.33
摘要:
目的:检测宫颈癌组织中人乳头瘤病毒(HPV)感染率及人半翼基因(HWAPL)蛋白表达水平,探讨高危型HPV感染与HWAPL蛋白表达的关系。方法:收集宫颈上皮内瘤变(CIN)组织及宫颈癌组织石蜡标本共132例,其中CINⅠ 29例、CINⅡ 28例、CINⅢ 35例、宫颈癌40例,应用HPV分型基因芯片系统检测其内HPV并分型,应用PV9000法进行HWAPL染色。结果:宫颈癌和CINⅢ组织中高危型HPV阳性率高于CINⅡ和CINⅠ组织(χ2=34.560,P<0.001)。宫颈癌和CIN组织中HWAPL蛋白表达强度比较,差异有统计学意义(H=58.981,P<0.001)。高危型HPV感染与HWAPL蛋白表达有关联(rP=0.356,P=0.001)。结论:HWAPL蛋白异常表达可能是高危型HPV致宫颈癌发病的重要环节。
Abstract:
Aim: To detect the infection rate of highrisk HPV and the expression level of HWAPL in cervical cancer tissue and to investigate the relationship between them. Methods: Gene chip technology was used to detect HPV genotyping,at the same time PV9000 immunohistochemistry was used to detect HWAPL protein expression in 132 specimens(including CINⅠ 29 cases, CINⅡ28 cases, CINⅢ 35 cases, and cervical cancer 40 cases).Results: The positive rates of highrisk HPV in cervical cancer and CINⅢ were significantly higher than those in CINⅡ and CINⅠ(χ2=34.560,P<0.001). The expression level of HWAPL protein in cervical cancer and CIN were significantly different(H=58.981,P<0.001). Highrisk HPV infection was positively correlated with HWAPL protein expression (rP=0.356,P=0.001). Conclusion: The abnormal expression of HWAPL may be an important part for highrisk HPV induced cervical cancer.

参考文献/References:

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备注/Memo

备注/Memo:
△男,1979年6月生,硕士,主治医师,研究方向:妇科肿瘤的防治,Email:149845691@qq.com
更新日期/Last Update: 2014-11-26