[1]赵鹏),朱红灿)#,李玉生),等.帕金森病患者认知功能障碍的发生率及影响因素[J].郑州大学学报(医学版),2014,(06):869.
 ZHAO Peng),ZHU Hongcan),LI Yusheng),et al.Incidence and related factors of Parkinson′s disease with cognitive dysfunction[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(06):869.
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帕金森病患者认知功能障碍的发生率及影响因素
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2014年06期
页码:
869
栏目:
应用研究
出版日期:
2014-11-20

文章信息/Info

Title:
Incidence and related factors of Parkinson′s disease with cognitive dysfunction
作者:
赵鹏12)朱红灿2)#李玉生2)赵幸娟1)郑亚珂2)李薇1)
1)郑州市第一人民医院神经内科 郑州 4500032)郑州大学第一附属医院神经内科 郑州 450052
Author(s):
ZHAO Peng12)ZHU Hongcan2)LI Yusheng2)ZHAO Xingjuan1)ZHENG Yake2)LI Wei1)
1)Department of Neurology, the First People's Hospital of Zhengzhou City, Zhengzhou 4500032)Department of Neurology,the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
帕金森病认知功能障碍蒙特利尔认知评估影响因素
Keywords:
Parkinson′s diseasecognitive dysfunctionMontreal cognitive assessmentinfluence factor
分类号:
R742.5
摘要:
目的:研究帕金森病(PD)患者认知功能障碍的发生率、临床特点及其相关影响因素。方法:应用蒙特利尔认知评估(MoCA)量表对52例PD患者(PD组)和58例健康对象(对照组)进行评定,探讨PD组患者认知功能障碍的发生率、临床特点及PD患者认知功能障碍与年龄、病程、HY分级、UPDRS评分的关系。结果:PD组MoCA评分(20.28±4.16)低于对照组(26.28±3.61)(t=8.036,P<0.001),PD组患者认知功能障碍发生率(57.7%,30例)高于对照组(10.3%,6例)(χ2=19.200,P<0.001)。PD患者认知功能障碍的主要特点表现为注意与集中、执行功能、延迟回忆、语言、视结构技能、抽象思维和定向力等下降。Logistic回归分析显示PD组认知功能障碍与患者病情严重程度(HY分级)、病程、UPDRS(第1部分)评分、UPDRS(第2部分)评分有关(OR:5.464,6.172,1.138,1.305; 95%CI:1.915~10.136,0.068~0.872,1.017~1.358,1.316~11.014)。结论:PD患者认知功能障碍发生率高,临床表现多样,其与病程、病情轻重、URPDS评分有关。
Abstract:
Aim: To study the incidence, clinical characteristics and related factors of cognitive dysfunction in Parkinson′s disease(PD). Methods: A total of 52 patients with Parkinson′s disease (PD group) and 58 healthy patients (normal group) were assessed by Montreal cognitive assessment(MoCA) scale,to study the incidence of cognitive dysfunction, clinical characteristics in PD patients and the relationship between the PD patients with cognitive dysfunction and age, duration, HoehnYahr grade, UPDRS score. Results: The MoCA score in PD group was lower than that in normal group(t=8.036,P<0.001), the incidence of cognitive dysfunction was 57.7% in the PD group(χ2=19.200,P<0.001). The main features of cognitive dysfunction in PD patients showed attention and concentration, executive functions, memory, delayed recall, language skills, visual ability, abstract thinking and ability of orientation, retardation, etc. Logistic regression analysis showed that cognitive dysfunction in PD group was positively related with the severity of disease condition (HY classification), duration, UPDRS (Part Ⅰ) score and UPDRS (Part Ⅱ) score(OR:5.464,6.172,1.138,1.305; 95%CI:1.915-10.136,0.068-0.872,1.017-1.358,1.316-11.014). Conclusion: The incidence of cognitive dysfunction in PD patients is high. There are many forms of clinical manifestations, and the extent of these manifestations is correlated with disease duration, severity and UPDRS score.

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备注/Memo

备注/Memo:
#通讯作者,男,1966年4月生,博士,主任医师,研究方向:帕金森病、脑血管病的诊治,Email:zhc660407@hotmail.com
更新日期/Last Update: 2014-11-26